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Hbb Complex/Cluster/Region Detail
Summary
  • Symbol
    Hbb
  • Name
    hemoglobin beta chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96020
    NCBI Gene: 15127
  • Cluster Members
    Hbb-bt, Hbb-bs, Hbb-bh3 ... (10 members)
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    173 experiments
  • Sequence Tag for
    D7Nds7
Human Diseases
more
  • Diseases
    2 with Hbb mouse models

Human Disease Mouse Models
       Beta-Thalassemia   OMIM: 613985 View 3 models
Hemoglobin--Beta Locus; HBB   OMIM: 141900 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    11 with disease annotations
  • References
    28 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    104 phenotypes from multigenic genotypes
    3 images
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (ENU)
    5
  • Chemically induced (other)
    1
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    9
  • Genomic Mutations
    1 involving Hbb
Mice homozygous or heterozygous for alleles of this gene exhibit varying degrees of hematopoietic defects.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    9
  • Tissues
    7
  • Literature Summary
    15
Sequences &
Gene Models
less
Polymorphisms
less
  • PCR
    4
  • RFLP
    9
Molecular
Reagents
less
  • All nucleic 17
    Genomic 3
    cDNA 7
    Primer pair 5
    Other 2
Other
Accession IDs
less
MGD-MRK-10632
References
more
  • Summaries
    All 329
    Developmental Gene Expression 15
    Diseases 28
    Phenotypes 149
  • Earliest
    J:110 Popp RA, et al., Studies on the mouse hemoglobin locus. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J Hered. 1960;51:141-144
  • Latest
    J:232634 Sparkenbaugh EM, et al., Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. Blood. 2016 Mar 10;127(10):1371-3
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory