Hbb MGI Mouse Complex/Cluster/Region Detail - MGI:96020

Hbb Complex/Cluster/Region Detail

Symbol

Hbb
Name

hemoglobin beta chain complex

Feature Type

complex/cluster/region
IDs

MGI:96020
NCBI Gene: 15127
Cluster Members

Hbb-bt, Hbb-bs, Hbb-bh3 ... (10 members)
Regulated by

Rr320 (1 regulatory region)

Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 7, Syntenic
Mapping Data

173 experiments

PCR

4
RFLP

9

Diseases

1 with Hbb mouse models

Human Disease

Mouse Models

beta thalassemia

IDs

View 6 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

8 with disease annotations

References

11 with disease annotations

less

Phenotype Summary

36 phenotypes from 8 alleles in 7 genetic backgrounds
109 phenotypes from multigenic genotypes
3 images
346 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

5
Chemically induced (other)

1
Spontaneous

1
Targeted

10
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous or heterozygous for alleles of this gene exhibit varying degrees of hematopoietic defects.

less

All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

13
Tissues

11
cDNA Data

1
Literature Summary

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

less

NCBI Gene

15127

less

All nucleic 19

Genomic 3

cDNA 8

Primer pair 6

Other 2

less

MGD-MRK-10632

Summaries

All 556

Developmental Gene Expression 19

Diseases 11

Gene Ontology 1

Phenotypes 346
Earliest

J:110 Popp RA, et al., Studies on the mouse hemoglobin locus. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J Hered. 1960;51(3):141-144
Latest

J:368065 Zhao Z, et al., Sickle cell disease induces chromatin introversion and ferroptosis in CD8(+) T cells to suppress anti-tumor immunity. Immunity. 2025 Jun 10;58(6):1484-1501.e11

Hbb expression regulated by:

Feature	Feature Type	Location	Reference
Rr320, regulatory region 320	locus control region	Chr7:103501973-103526752 (+)	J:22204

Hbb Cluster contains:

More Data for these features

Member	Feature Type	Location
Hbb-bt, hemoglobin, beta adult t chain	protein coding gene	Chr7:103461731-103463130 (-)
Hbb-bs, hemoglobin, beta adult s chain	protein coding gene	Chr7:103475730-103477135 (-)
Hbb-bh3, hemoglobin beta, pseudogene bh3	pseudogene	Chr7:103481835-103482930 (-)
Hbb-bh2, hemoglobin beta, bh2	protein coding gene	Chr7:103488331-103489727 (-)
Hbb-bh1, hemoglobin Z, beta-like embryonic chain	protein coding gene	Chr7:103490845-103492369 (-)
Hbb-bh0, hemoglobin, beta, pseudogene bh0	pseudogene	Chr7:103499227-103499355 (-)
Hbb-y, hemoglobin Y, beta-like embryonic chain	protein coding gene	Chr7:103500961-103502414 (-)
Rr320, regulatory region 320	locus control region	Chr7:103501973-103526752 (+)
Hbb-b1, hemoglobin, beta adult major chain	protein coding gene	Chr7, Syntenic
Hbb-b2, hemoglobin, beta adult minor chain	protein coding gene	Chr7, Syntenic

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24