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Hbb Complex/Cluster/Region Detail
Summary
  • Symbol
    Hbb
  • Name
    hemoglobin beta chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96020
    NCBI Gene: 15127
  • Cluster Members
    Hbb-bt, Hbb-bs, Hbb-bh3 ... (10 members)
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    173 experiments
  • Sequence Tag for
Strain
Comparison
more
  • PCR
  • RFLP
Human Diseases
more
  • Diseases
    1 with Hbb mouse models

Human Disease Mouse Models
      
IDs
View 7 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    14 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 8 alleles in 7 genetic backgrounds
    117 phenotypes from multigenic genotypes
    3 images
    242 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for alleles of this gene exhibit varying degrees of hematopoietic defects.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 8
      Primer pair 6
      Other 2
    Other
    Accession IDs
    less
    MGD-MRK-10632
    References
    more
    • Summaries
      All 452
      Developmental Gene Expression 17
      Diseases 12
      Phenotypes 242
    • Earliest
      J:110 Popp RA, et al., Studies on the mouse hemoglobin locus. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J Hered. 1960;51:141-144
    • Latest
      J:330721 Chaichompoo P, et al., Increased autophagy leads to decreased apoptosis during beta-thalassaemic mouse and patient erythropoiesis. Sci Rep. 2022 Nov 3;12(1):18628

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/22/2022
    MGI 6.22
    The Jackson Laboratory