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Hbb Complex/Cluster/Region Detail
Summary
  • Symbol
    Hbb
  • Name
    hemoglobin beta chain complex
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    173 experiments
  • Sequence Tag for
    D7Nds7
Human Diseases
more
  • Diseases
    1 with Hbb mouse models

Human Disease Mouse Models
      
IDs
 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    111 phenotypes from multigenic genotypes
    3 images
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (ENU)
    5
  • Chemically induced (other)
    1
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    9
  • Genomic Mutations
    1 involving Hbb
  • Find Mice (IMSR)
    26 strains or lines available
Mice homozygous or heterozygous for alleles of this gene exhibit varying degrees of hematopoietic defects.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    9
  • Tissues
    7
  • Literature Summary
    15
Sequences &
Gene Models
less
Polymorphisms
less
  • PCR
    4
  • RFLP
    9
Molecular
Reagents
less
  • All nucleic 17
    Genomic 3
    cDNA 7
    Primer pair 5
    Other 2
Other
Accession IDs
less
MGD-MRK-10632
References
more
  • Summaries
    All 354
    Developmental Gene Expression 15
    Diseases 11
    Phenotypes 158
  • Earliest
    J:110 Popp RA, et al., Studies on the mouse hemoglobin locus. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J Hered. 1960;51:141-144
  • Latest
    J:242997 Li C, et al., Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. Mol Cell Biol. 2016 Nov 15;36(22):2838-2854
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory