Phenotypes Associated with This Genotype

Genotype
MGI:2450728

• Allelic Composition: Hbb^tm1Unc/Hbb^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:4932 )

• death in utero at close to term or just after birth

hematopoietic system

anemia ( J:4932 )

• severe anemia

abnormal erythrocyte morphology ( J:4932 )

• blood shows few normally rounded red cells

decreased hematocrit ( J:4932 )

• decreased hematocrits at E18.5

decreased mean corpuscular hemoglobin ( J:4932 )

• hypochromic red blood cells

poikilocytosis ( J:4932 )

reticulocytosis ( J:4932 )

• presence of nucleated red blood cell precursors

integument

pallor ( J:4932 )

• pallor evident at E16.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:4932