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Hat1 Gene Detail
Summary
  • Symbol
    Hat1
  • Name
    histone aminotransferase 1
  • Synonyms
    2410071B14Rik, KAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96013
    NCBI Gene: 107435
  • Gene Overview
    MyGene.info: HAT1
Location & Maps
more
  • Sequence Map
    Chr2:71388958-71441622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HAT1, histone acetyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAT1, histone acetyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KAT1
  • Links
    NCBI Gene ID: 8520
    neXtProt AC: NX_O14929

  • Chr Location
    2q31.1; chr2:171922425-171983686 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    78
  • Chemically induced (other)
    1
  • Gene trapped
    73
  • Targeted
    4
  • Genomic Mutations
    1 involving Hat1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit prenatal, perinatal and neonatal lethality with impaired lung maturation, atelectasis, respiratory failure, craniofacial defects and decreased proliferation of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013187 VEGA Gene Model | MGI Sequence Detail 52665 C57BL/6J ±  kb
transcript OTTMUST00000031861 VEGA | MGI Sequence Detail 1899 Not Applicable  
polypeptide OTTMUSP00000014193 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    382 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 109

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10621, MGD-MRK-10622, MGI:1914626, MGI:2138791
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:6128 Bulfield G, Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1). Biochem Genet. 1978 Dec;16(11-12):1233-41
  • Latest
    J:199077 Nagarajan P, et al., Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS Genet. 2013 Jun;9(6):e1003518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory