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Hat1 Gene Detail
Summary
  • Symbol
    Hat1
  • Name
    histone aminotransferase 1
  • Synonyms
    2410071B14Rik, KAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96013
    NCBI Gene: 107435
  • Gene Overview
    MyGene.info: HAT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:71388958-71441622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HAT1, histone acetyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAT1, histone acetyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KAT1
  • Links
    NCBI Gene ID: 8520
    neXtProt AC: NX_O14929
    UniProt: O14929

  • Chr Location
    2q31.1; chr2:171922425-171983686 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal, perinatal and neonatal lethality with impaired lung maturation, atelectasis, respiratory failure, craniofacial defects and decreased proliferation of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013187 VEGA Gene Model | MGI Sequence Detail 52665 C57BL/6J ±  kb
    transcript OTTMUST00000031861 VEGA | MGI Sequence Detail 1899 Not Applicable  
    polypeptide OTTMUSP00000014193 VEGA | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      382 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR016181 Acyl-CoA N-acyltransferase
      IPR037113 Histone acetyl transferase 1, N-terminal domain superfamily
      IPR013523 Histone acetyltransferase HAT1, C-terminal
      IPR019467 Histone acetyl transferase HAT1 N-terminal
      IPR017380 Histone acetyltransferase type B, catalytic subunit
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10621, MGD-MRK-10622, MGI:1914626, MGI:2138791
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:6128 Bulfield G, Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1). Biochem Genet. 1978 Dec;16(11-12):1233-41
    • Latest
      J:245493 Agudelo Garcia PA, et al., Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly. Nucleic Acids Res. 2017 Sep 19;45(16):9319-9335

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory