Hao2
Gene Detail

Symbol Name ID

Hao2 hydroxyacid oxidase 2 MGI:96012

Synonyms

Hao3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

42.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr3:98874577-98893239 bp, - strand From VEGA annotation of GRCm38   18663 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:97412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-hydroxy acid dehydrogenase, FMN-dependent
Gene Tree: Hao2

Human homologs

Human Homolog		HAO2, hydroxyacid oxidase 2 (long chain)
NCBI Gene ID		51179
neXtProt AC		NX_Q9NYQ3
Human Synonyms		GIG16, HAOX2
Human Chr (Location)		1p13.3-p13.1; chr1:119911402-119936751 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Electrophoretic variants are known for this locus in kidney. The a allele determines a slow anodally migrating band in all inbred strains tested; the b allele determines a fast band in M. m. castaneus.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	fatty acid oxidation, mandelate metabolic process, ...
Component	mitochondrion, peroxisome
Function	catalytic activity, FMN binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (104)    Tissues (98)    Images (11)
Theiler Stages: 22, 23, 24

Assay Type	Results
RNA in situ	104

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(52)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006827 (Evidence)
Ensembl Gene Model	ENSMUSG00000027870 (Evidence)
Entrez Gene	56185 (Evidence)
UniGene	281874
DFCI	TC1580327
DoTS	DT.529276
EC	1.1.3.1, 1.1.3.15
Consensus CDS Project	CCDS17671.1
International Mouse Knockout Project Status	Hao2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006827	VEGA Gene Model | MGI Sequence Detail	18663	C57BL/6J
transcript	OTTMUST00000015762	VEGA | MGI Sequence Detail	1993	Not Applicable
polypeptide	OTTMUSP00000007242	VEGA | MGI Sequence Detail	353	Not Applicable

All sequences(24) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(137 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR012133	Alpha-hydroxy acid dehydrogenase, FMN-dependent
InterPro	IPR008259	FMN-dependent alpha-hydroxy acid dehydrogenase, active site
InterPro	IPR000262	FMN-dependent dehydrogenase
Protein Ontology	PR:000008442	hydroxyacid oxidase 2

References

(Earliest) J:25456 Holmes RS, et al., Genetics of mouse Peroxisomal Enzymes. Mouse News Lett. 1976;54:32-33
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(51)

Other accession IDs

MGD-MRK-10617, MGD-MRK-10619, MGI:1860477, MGI:2139681