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Hal Gene Detail
Summary
  • Symbol
    Hal
  • Name
    histidine ammonia lyase
  • Synonyms
    histidase, Hsd
  • Feature Type
    protein coding gene
  • IDs
    MGI:96010
    NCBI Gene: 15109
  • Gene Overview
    MyGene.info: HAL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:93488768-93519304 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30537 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.49 cM, cytoband C2-D1
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    HAL, histidine ammonia-lyase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAL, histidine ammonia-lyase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HIS, HSTD
  • Links
    NCBI Gene ID: 3034
    neXtProt AC: NX_P42357
    UniProt: P42357

  • Chr Location
    12q23.1; chr12:95972662-95996365 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause elevated histidine levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030965 VEGA Gene Model | MGI Sequence Detail 30537 C57BL/6J ±  kb
    transcript OTTMUST00000076673 VEGA | MGI Sequence Detail 5319 Not Applicable  
    polypeptide OTTMUSP00000040404 VEGA | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      466 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:5382 Kacser H, et al., Histidinaemic mutant in the mouse. Nature. 1973 Jul 13;244(5411):77-9
    • Latest
      J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory