Hal
Gene Detail

Symbol Name ID

Hal histidine ammonia lyase MGI:96010

Synonyms

histidase, Hsd

Feature Type

protein coding gene

Genetic Map

Chromosome 10

48.49 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr10:93488768-93519304 bp, + strand From VEGA annotation of GRCm38   30537 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histidine ammonia-lyase
Gene Tree: Hal

Human homologs

Human Homolog		HAL, histidine ammonia-lyase
NCBI Gene ID		3034
neXtProt AC		NX_P42357
Human Synonyms		HIS, HSTD
Human Chr (Location)		12q22-q24.1; chr12:96366440-96390143 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HAL

Alleles and phenotypes

All alleles(4) : Gene trapped(3) Spontaneous(1)
 

Mutations in this gene cause elevated histidine levels.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	biosynthetic process, histidine catabolic process, ...
Component	cytoplasm
Function	ammonia-lyase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) cDNA(56)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030965 (Evidence)
Ensembl Gene Model	ENSMUSG00000020017 (Evidence)
Entrez Gene	15109 (Evidence)
UniGene	13000
DFCI	TC1579640
DoTS	DT.494415, DT.94251600
NIA Mouse Gene Index	U011898
EC	4.3.1.3
Consensus CDS Project	CCDS36036.1
International Mouse Knockout Project Status	Hal

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030965	VEGA Gene Model | MGI Sequence Detail	30537	C57BL/6J
transcript	OTTMUST00000076673	VEGA | MGI Sequence Detail	5319	Not Applicable
polypeptide	OTTMUSP00000040404	VEGA | MGI Sequence Detail	657	Not Applicable

All sequences(33) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(8) : SNPs(147 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001106	Aromatic amino acid lyase
InterPro	IPR005921	Histidine ammonia-lyase
InterPro	IPR008948	L-Aspartase-like
InterPro	IPR024083	L-Aspartase-like, N-terminal
InterPro	IPR022313	Phenylalanine/histidine ammonia-lyases, active site
Protein Ontology	PR:000008437	histidine ammonia-lyase

References

(Earliest) J:15065 Wallace ME, his. Mouse News Lett. 1970;42:20
(Latest) J:182107 Barresi C, et al., Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection. J Invest Dermatol. 2011 Jan;131(1):188-94
All references(55)

Other accession IDs

MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944