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Hal
Gene Detail
 Symbol
Name
ID
Hal
histidine ammonia lyase
MGI:96010
Synonyms histidase, Hsd
Feature Type protein coding gene
Genetic Map
Chromosome 10
48.49 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr10:93488768-93519304 bp, + strand
From VEGA annotation of GRCm38

  30537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histidine ammonia-lyase
Gene Tree: Hal

Human
homologs
Human Homolog HAL, histidine ammonia-lyase
NCBI Gene ID 3034
neXtProt AC  NX_P42357
Human Synonyms  HIS, HSTD
Human Chr (Location)  12q22-q24.1; chr12:95972662-95996365 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HAL
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause elevated histidine levels.
 
Interactions
Hal interacts with 292 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process biosynthetic process, histidine catabolic process, ...
Component cytoplasm
Function ammonia-lyase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) cDNA(56)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030965 (Evidence)
Ensembl Gene ModelENSMUSG00000020017 (Evidence)
Entrez Gene15109 (Evidence)
UniGene13000
DFCITC1579640
DoTSDT.494415, DT.94251600
NIA Mouse Gene IndexU011898
EC4.3.1.3
Consensus CDS ProjectCCDS36036.1
International Mouse Knockout Project StatusHal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030965 VEGA Gene Model | MGI Sequence Detail 30537 C57BL/6J ±  kb
transcript OTTMUST00000076673 VEGA | MGI Sequence Detail 5319 Not Applicable 
polypeptide OTTMUSP00000040404 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(5)
Polymorphisms RFLP(8) : SNPs within 2kb(477 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001106 Aromatic amino acid lyase
InterPro IPR024083 Fumarase/histidase, N-terminal
InterPro IPR005921 Histidine ammonia-lyase
InterPro IPR008948 L-Aspartase-like
InterPro IPR022313 Phenylalanine/histidine ammonia-lyases, active site
Protein Ontology PR:000008437 histidine ammonia-lyase
References (Earliest) J:15065 Wallace ME, his. Mouse News Lett. 1970;42:20
(Latest) J:182107 Barresi C, et al., Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection. J Invest Dermatol. 2011 Jan;131(1):188-94
All references(55)
Other
accession IDs
MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory