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H2-T3 Gene Detail
Summary
  • Symbol
    H2-T3
  • Name
    histocompatibility 2, T region locus 3
  • Synonyms
    H-2T3, H2-Tw3, TL
  • Feature Type
    protein coding gene
  • IDs
    MGI:95959
    NCBI Gene: 15043
Location & Maps
more
  • Sequence Map
    Chr17:36185572-36190287 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4716 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.99 cM
  • Mapping Data
    3 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    9 phenotypes from multigenic genotypes
    6 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving H2-T3
  • Incidental Mutations
    APF
This locus contains the sole gene encoding the thymic leukemia antigen or TL antigen in "b haplotype" mice such as C57BL/6. Mice homozygous for a targeted knock-out are viable with normal reproduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014949 VEGA Gene Model | MGI Sequence Detail 4716 C57BL/6J ±  kb
transcript OTTMUST00000035487 VEGA | MGI Sequence Detail 2312 Not Applicable  
polypeptide OTTMUSP00000015889 VEGA | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000008413 H-2 class I histocompatibility antigen, TLA(B) alpha chain
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR027648 MHC class I alpha chain
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
Molecular
Reagents
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  • All nucleic 30
    Genomic 25
    cDNA 3
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-10441, MGD-MRK-10555
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:5845 Flaherty L, et al., The Tla locus: a new allele and antigenic specificity. J Immunol. 1977 Aug;119(2):571-5
  • Latest
    J:179320 Olivares-Villagomez D, et al., Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J Immunol. 2011 Oct 15;187(8):4051-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory