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H2-Q7
Gene Detail
 Symbol
Name
ID
H2-Q7
histocompatibility 2, Q region locus 7
MGI:95936
Synonyms H-2Q7, Ped, Qa7, Qa-7
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:35439155-35443769 bp, + strand
From VEGA annotation of GRCm38

  4615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q7

Human
homologs
Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Genomic Mutations involving H2-Q7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls a widely distributed lymphocyte antigen recognized by monoclonal antibody, serology or CTL assay. Using all assays, antigen is present (allele a) in C57BL/6, DBA/1, DBA/2 and SWR and absent (allele b) in AKR, C3H and BALB/c. Other strain allele typings were assay-dependent.
 
Interactions
H2-Q7 interacts with 64 markers (Mir1b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (27)    Images (2)
Theiler Stages: 1, 2, 3, 4, 5, 15, 19, 20, 22, 28
Assay TypeResults
RT-PCR 52
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(19) cDNA(3) Primer pair(2) Other(5)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000037191 (Evidence)
Ensembl Gene ModelENSMUSG00000060550 (Evidence)
Entrez Gene15018 (Evidence)
PDB1K8D
Consensus CDS ProjectCCDS28697.1, CCDS57075.1, CCDS57076.1
International Mouse Knockout Project StatusH2-Q7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037191 VEGA Gene Model | MGI Sequence Detail 4615 C57BL/6J ±  kb
transcript OTTMUST00000095869 VEGA | MGI Sequence Detail 1406 Not Applicable 
polypeptide OTTMUSP00000053520 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(14) UniProt(5)
Polymorphisms RFLP(4) : SNPs within 2kb(49 from dbSNP Build 137)    SNPs within 2kb including multiple locations(129)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000008410 H-2 class I histocompatibility antigen, Q7 alpha chain
References (Earliest) J:11962 Steinmetz M, et al., A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell. 1981 Sep;25(3):683-92
(Latest) J:136804 Ohtsuka M, et al., Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. BMC Genomics. 2008;9:178
All references(41)
Other
accession IDs
MGD-MRK-10419, MGD-MRK-10532, MGD-MRK-13227, MGD-MRK-13710, MGD-MRK-13715, MGD-MRK-13726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory