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H2-Q6
Gene Detail
Symbol

Name
ID
H2-Q6
histocompatibility 2, Q region locus 6
MGI:95935
Synonyms
0610037M15Rik, H-2Q6, Qa6, Qa-6
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:35424850-35430055 bp, + strand
From VEGA annotation of GRCm38

  5206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q6

Human
homologs
Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Genomic Mutations involving H2-Q6 (1)
 
This locus controls a lymph node and splenic lymphocyte antigen detected by BALB/cBy anti-ORA1-a tumor antibody. The strain distribution for presence/absence of antigen varies widely among inbred strains.
 
Interactions
H2-Q6 interacts with 122 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (27)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 45
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(21) cDNA(2) Primer pair(3) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037190 (Evidence)
Ensembl Gene ModelENSMUSG00000073409 (Evidence)
Entrez Gene110557 (Evidence)
DFCITC1599462, TC1599615, TC1600512
NIA Mouse Gene IndexU040519
Consensus CDS ProjectCCDS37598.1
International Mouse Knockout Project StatusH2-Q6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037190 VEGA Gene Model | MGI Sequence Detail 5206 C57BL/6J ±  kb
transcript OTTMUST00000095868 VEGA | MGI Sequence Detail 2085 Not Applicable 
polypeptide OTTMUSP00000053519 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(46) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(42 from dbSNP Build 137)    SNPs within 2kb including multiple locations(94)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
References
(Earliest) J:6916 Flaherty L, et al., Syngeneic tumor immunizations produce Qa antibodies. Discovery of a new Qa antigen, Qa-6. Immunogenetics. 1982;16(4):329-37
(Latest) J:136804 Ohtsuka M, et al., Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. BMC Genomics. 2008;9:178
All references(34)
Other
accession IDs
MGD-MRK-10418, MGD-MRK-10531, MGD-MRK-13714, MGD-MRK-13725, MGI:1915645

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory