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H2-Q6 Gene Detail
Summary
  • Symbol
    H2-Q6
  • Name
    histocompatibility 2, Q region locus 6
  • Synonyms
    0610037M15Rik, H-2Q6, Qa6, Qa-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95935
    NCBI Gene: 110557
  • Gene Overview
    MyGene.info: HLA-A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35424877-35428361 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    7
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95935
protein coding gene Chr17:35424850-35430055 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023638
protein coding gene Chr17:35605620-35613953 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0023563
protein coding gene Chr17:34732611-34739521 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0023365
protein coding gene Chr17:35240663-35246535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024041
protein coding gene Chr17:37052919-37063466 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023342
protein coding gene Chr17:38271449-38278357 (+)
DBA/2J MGP_DBA2J_G0023385
protein coding gene Chr17:32174288-32179193 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    57

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
This locus controls a lymph node and splenic lymphocyte antigen detected by BALB/cBy anti-ORA1-a tumor antibody. The strain distribution for presence/absence of antigen varies widely among inbred strains.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110557 NCBI Gene Model | MGI Sequence Detail 3485 C57BL/6J ±  kb
transcript NM_001368741 RefSeq | MGI Sequence Detail 2180 C57BL/6  
polypeptide NP_001355670 RefSeq | MGI Sequence Detail 326 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
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  • All nucleic 29
    Genomic 21
    cDNA 2
    Primer pair 3
    Other 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10418, MGD-MRK-10531, MGD-MRK-13714, MGD-MRK-13725, MGI:1915645
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:6916 Flaherty L, et al., Syngeneic tumor immunizations produce Qa antibodies. Discovery of a new Qa antigen, Qa-6. Immunogenetics. 1982;16(4):329-37
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory