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H2-Q4
Gene Detail
 Symbol
Name
ID
H2-Q4
histocompatibility 2, Q region locus 4
MGI:95933
Synonyms H2-Gs10, H-2Q4, Qa4, Qa-4, Qat-4, Qb1, Qb-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:35379617-35385290 bp, + strand
From VEGA annotation of GRCm38

  5674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q4

Human
homologs
Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Genomic Mutations involving H2-Q4 (1)
Incidental mutations (data from APF )
 
This locus controls an antigen on peripheral T-cells of spleen, lymph node and bone marrow, but not on thymocytes. Strain distribution patterns vary by assay, measuring presence/absence of antigen, protein acidic/basic qualities and molecular polymorphisms.
 
Interactions
H2-Q4 interacts with 74 markers (Mir19a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process antigen processing and presentation of peptide antigen via MHC class I
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (20)    Images (2)
Theiler Stages: 15, 19, 20, 22, 28
Assay TypeResults
RT-PCR 24
cDNA source data(45)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(89) Genomic(35) cDNA(46) Primer pair(2) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037138 (Evidence)
Ensembl Gene ModelENSMUSG00000035929 (Evidence)
Entrez Gene15015 (Evidence)
UniGene464284
DFCITC1582197
DoTSDT.101209744, DT.91347520, DT.94218206
Consensus CDS ProjectCCDS50087.1
International Mouse Knockout Project StatusH2-Q4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037138 VEGA Gene Model | MGI Sequence Detail 5674 C57BL/6J ±  kb
transcript OTTMUST00000095617 VEGA | MGI Sequence Detail 1793 Not Applicable 
polypeptide OTTMUSP00000053359 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(11) UniProt(5)
Polymorphisms All PCR and RFLP(14) : PCR(4) RFLP(10) SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(72)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
References (Earliest) J:6148 Hammerling GJ, et al., Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. J Exp Med. 1979 Jul 1;150(1):108-16
(Latest) J:137349 Swanson PA 2nd, et al., An MHC class Ib-restricted CD8 T cell response confers antiviral immunity. J Exp Med. 2008 Jul 7;205(7):1647-57
All references(40)
Other
accession IDs
MGD-MRK-10416, MGD-MRK-10529, MGD-MRK-13712, MGD-MRK-13723, MGD-MRK-13729, MGD-MRK-13731, MGD-MRK-13732, MGI:3808875

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory