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H2-Q2 Gene Detail
Summary
  • Symbol
    H2-Q2
  • Name
    histocompatibility 2, Q region locus 2
  • Synonyms
    Gm11132, H-2Q2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95931
    NCBI Gene: 15013
  • Gene Overview
    MyGene.info: HLA-A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35342307-35346764 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.64 cM, cytoband B-C
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • Strain Annotations
    8
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95931
protein coding gene Chr17:35342117-35346764 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021434
protein coding gene Chr17:30304801-30308574 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0023467
protein coding gene Chr17:33567421-33571108 (+)
FVB/NJ MGP_FVBNJ_G0023437
protein coding gene Chr17:33501257-33504830 (+)
LP/J MGP_LPJ_G0023546
protein coding gene Chr17:35855496-35859102 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023458
protein coding gene Chr17:37294427-37297979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024084
protein coding gene Chr17:35102096-35105833 (+)
PWK/PhJ MGP_PWKPhJ_G0022605
protein coding gene Chr17:32563366-32566303 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    57
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
    Orthology source: HomoloGene
  • Synonyms
    HLAA
  • Links
    NCBI Gene ID: 3105
    neXtProt AC: NX_P04439, NX_P30443
    UniProt: P04439

  • Chr Location
    6p22.1; chr6:29942470-29945884 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15013 NCBI Gene Model | MGI Sequence Detail 4458 C57BL/6J ±  kb
transcript NM_010392 RefSeq | MGI Sequence Detail 2032 C57BL/6  
polypeptide NP_034522 RefSeq | MGI Sequence Detail 360 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR010579 MHC class I, alpha chain, C-terminal
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
less
  • All nucleic 23
    Genomic 11
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10414, MGD-MRK-10527, MGI:3035350, MGI:3779387
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:4437 Flaherty L, et al., Further seriological analysis of the Qa antigens: analysis of an anti-H-2.28 serum. Immunogenetics. 1978;6:245-251
  • Latest
    J:190754 Ermakova O, et al., Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome. 2012 Aug;23(7-8):443-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory