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H2-Q10 Gene Detail
Summary
  • Symbol
    H2-Q10
  • Name
    histocompatibility 2, Q region locus 10
  • Synonyms
    H-2Q10, Q10, Qa10
  • Feature Type
    protein coding gene
  • IDs
    MGI:95929
    NCBI Gene: 15007
  • Gene Overview
    MyGene.info: HLA-A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35470089-35474563 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    12
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95929
protein coding gene Chr17:35470089-35474563 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023639
protein coding gene Chr17:35639989-35643332 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0023596
protein coding gene Chr17:35698802-35701985 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0023363
protein coding gene Chr17:35118460-35123143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024040
protein coding gene Chr17:37052892-37064467 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023341
protein coding gene Chr17:38271448-38274694 (+)
DBA/2J MGP_DBA2J_G0023383
protein coding gene Chr17:32150550-32153816 (-)
FVB/NJ MGP_FVBNJ_G0023438
protein coding gene Chr17:33646659-33655504 (+)
LP/J MGP_LPJ_G0023547
protein coding gene Chr17:35995668-35998873 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023459
protein coding gene Chr17:37442708-37450010 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023999
protein coding gene Chr17:33534592-33539964 (-)
PWK/PhJ MGP_PWKPhJ_G0022607
protein coding gene Chr17:32711058-32717793 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    57
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
    Orthology source: HomoloGene
  • Synonyms
    HLAA
  • Links
    NCBI Gene ID: 3105
    neXtProt AC: NX_P04439
    UniProt: P04439

  • Chr Location
    6p22.1; chr6:29942470-29945884 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Unlike other class I genes, this gene is expressed only in liver cells and its product is secreted into the serum. The amount of protein in serum varies among inbred strains with different H2 haplotypes and is completely absent in the H2f strain B10.M. Homozygous knockout affects conventional NK (cNK) cell and gamma-delta T cell development in the liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15007 NCBI Gene Model | MGI Sequence Detail 4475 C57BL/6J ±  kb
transcript NM_010391 RefSeq | MGI Sequence Detail 1473 C57BL/6  
polypeptide P01898 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008409 H-2 class I histocompatibility antigen, Q10 alpha chain
  • PDB
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
less
  • All nucleic 24
    Genomic 11
    cDNA 9
    Primer pair 1
    Other 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10413, MGD-MRK-10525, MGD-MRK-13707, MGD-MRK-13719
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
  • Latest
    J:294888 Goodall KJ, et al., Multiple receptors converge on H2-Q10 to regulate NK and gammadeltaT-cell development. Immunol Cell Biol. 2019 Mar;97(3):326-339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory