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H2-Q10
Gene Detail
 Symbol
Name
ID
H2-Q10
histocompatibility 2, Q region locus 10
MGI:95929
Synonyms H-2Q10, Q10, Qa10
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:35470089-35474563 bp, + strand
From VEGA annotation of GRCm38

  4475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128352  Vertebrate Homology Class
1 human; 11 mouse; 12 rat; 1 chimpanzee; 1 rhesus macaque; 24 chicken; 7 zebrafish

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q10

Human
homologs
Human Homolog HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID 3105
neXtProt AC  NX_P01892, NX_P04439, NX_P30443, NX_P30450
Human Synonyms  HLAA
Human Chr (Location)  6p21.3; chr6:29942470-29945884 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HLA-A
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Genomic Mutations involving H2-Q10 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Unlike other class I genes, this gene is expressed only in liver cells and its product is secreted into the serum. The amount of protein in serum varies among inbred strains with different H2 haplotypes and is completely absent in the H2f strain B10.M.
 
Interactions
H2-Q10 interacts with 100 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, ...
Component cell surface, endoplasmic reticulum, ...
Function beta-2-microglobulin binding, peptide antigen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (20)    Images (2)
Theiler Stages: 15, 19, 20, 22, 28
Assay TypeResults
RT-PCR 24
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(11) cDNA(108) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037234 (Evidence)
Ensembl Gene ModelENSMUSG00000067235 (Evidence)
Entrez Gene15007 (Evidence)
UniGene88795
DFCITC1580287, TC1603796, TC1718533
DoTSDT.101166691, DT.101222659, DT.101258859, DT.87061146, DT.94237581
NIA Mouse Gene IndexU228076
Consensus CDS ProjectCCDS37599.1
International Mouse Knockout Project StatusH2-Q10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037234 VEGA Gene Model | MGI Sequence Detail 4475 C57BL/6J ±  kb
transcript OTTMUST00000096007 VEGA | MGI Sequence Detail 1991 Not Applicable 
polypeptide OTTMUSP00000053596 VEGA | MGI Sequence Detail 325 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(26) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(68 from dbSNP Build 137)    SNPs within 2kb including multiple locations(70)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000008409 H-2 class I histocompatibility antigen, Q10 alpha chain
References (Earliest) J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGD-MRK-10413, MGD-MRK-10525, MGD-MRK-13707, MGD-MRK-13719

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory