H2-Q10
Gene Detail

Symbol Name ID

H2-Q10 histocompatibility 2, Q region locus 10 MGI:95929

Synonyms

H-2Q10, Q10, Qa10

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:35470089-35474563 bp, + strand From VEGA annotation of GRCm38   4475 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128352  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 8 cattle; 3 dog; 26 chicken

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-Q10

Human homologs

Human Homolog		HLA-A, major histocompatibility complex, class I, A
NCBI Gene ID		3105
neXtProt AC		NX_P04439, NX_P30443
Human Synonyms		HLAA
Human Chr (Location)		6p21.3; chr6:29910247-29913661 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human HLA-A

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Unlike other class I genes, this gene is expressed only in liver cells and its product is secreted into the serum. The amount of protein in serum varies among inbred strains with different H2 haplotypes and is completely absent in the H2f strain B10.M.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, ...
Component	integral to membrane, membrane, ...
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (20)    Images (2)
Theiler Stages: 15, 19, 20, 22, 28

Assay Type	Results
RT-PCR	24

cDNA source data(103)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(118) Genomic(11) cDNA(103) Primer pair(1) Other(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037234 (Evidence)
Ensembl Gene Model	ENSMUSG00000067235 (Evidence)
Entrez Gene	15007 (Evidence)
UniGene	88795
DFCI	TC1580287, TC1603796, TC1718533
DoTS	DT.101166691, DT.101222659, DT.101258859, DT.87061146, DT.94237581
NIA Mouse Gene Index	U228076
Consensus CDS Project	CCDS37599.1
International Mouse Knockout Project Status	H2-Q10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037234	VEGA Gene Model | MGI Sequence Detail	4475	C57BL/6J
transcript	OTTMUST00000096007	VEGA | MGI Sequence Detail	1991	Not Applicable
polypeptide	OTTMUSP00000053596	VEGA | MGI Sequence Detail	325	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR011162	MHC classes I/II-like antigen recognition protein
InterPro	IPR001039	MHC class I, alpha chain, alpha1/alpha2
InterPro	IPR011161	MHC class I-like antigen recognition
Protein Ontology	PR:000008409	H-2 class I histocompatibility antigen, Q10 alpha chain

References

(Earliest) J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGD-MRK-10413, MGD-MRK-10525, MGD-MRK-13707, MGD-MRK-13719