About   Help   FAQ
H2-Oa Gene Detail
Summary
  • Symbol
    H2-Oa
  • Name
    histocompatibility 2, O region alpha locus
  • Synonyms
    H-2Oa
  • Feature Type
    protein coding gene
  • IDs
    MGI:95924
    NCBI Gene: 15001
  • Gene Overview
    MyGene.info: HLA-DOA
Location & Maps
more
  • Sequence Map
    Chr17:34092340-34095234 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2895 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HLA-DOA, major histocompatibility complex, class II, DO alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HLA-DOA, major histocompatibility complex, class II, DO alpha
    Orthology source: HomoloGene
  • Synonyms
    HLA-DNA, HLADZ, HLA-DZA
  • Links
    NCBI Gene ID: 3111
    neXtProt AC: NX_P06340

  • Chr Location
    6p21.3; chr6:33004182-33009612 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
    APF
Homozygous inactivation of this gene results in abnormal antigen presentation via MHC class II. Mice homozygous for a knock-out allele show enhanced selection of CD4+ single positive thymocytes. Mice homozygous for a different knock-out allele show increased serum IgG1 levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037090 VEGA Gene Model | MGI Sequence Detail 2895 C57BL/6J ±  kb
transcript OTTMUST00000095474 VEGA | MGI Sequence Detail 1088 Not Applicable  
polypeptide OTTMUSP00000053268 VEGA | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR032431 Immunoglobulin C1-set, C-terminal extension
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR001003 MHC class II, alpha chain, N-terminal
Molecular
Reagents
less
  • All nucleic 29
    Genomic 8
    cDNA 20
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10408, MGD-MRK-10520
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:1569 Karlsson L, et al., The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex. J Exp Med. 1992 Aug 1;176(2):477-83
  • Latest
    J:190823 Gu Y, et al., Immunodeficiency and autoimmunity in h2-o-deficient mice. J Immunol. 2013 Jan 1;190(1):126-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory