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H2-Oa
Gene Detail
Symbol

Name
ID
H2-Oa
histocompatibility 2, O region alpha locus
MGI:95924
Synonyms
H-2Oa
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:34092340-34095234 bp, + strand
From VEGA annotation of GRCm38

  2895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1601  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HLA-DOA
Gene Tree: H2-Oa

Human
homologs
HLA-DOA, major histocompatibility complex, class II, DO alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3111
neXtProt AC: NX_P06340

Human Synonyms: HLA-DNA, HLADZ, HLA-DZA

Human Chr (Location): 6p21.3; chr6:33004182-33009612 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous inactivation of this gene results in abnormal antigen presentation via MHC class II. Mice homozygous for a knock-out allele show enhanced selection of CD4+ single positive thymocytes. Mice homozygous for a different knock-out allele show increased serum IgG1 levels.
 
Interactions
H2-Oa interacts with 14 markers (Mir32, Mir141, Mir183, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (121)    Tissues (15)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(8) cDNA(20) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037090 (Evidence)
Ensembl Gene Model ENSMUSG00000024334 (Evidence)
Entrez Gene 15001 (Evidence)
UniGene 116
DFCI TC1584410
DoTS DT.531883, DT.94165438
NIA Mouse Gene Index U017844
Consensus CDS Project CCDS37577.1
International Mouse Phenotyping Consortium Status H2-Oa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037090 VEGA Gene Model | MGI Sequence Detail 2895 C57BL/6J ±  kb
transcript OTTMUST00000095474 VEGA | MGI Sequence Detail 1088 Not Applicable 
polypeptide OTTMUSP00000053268 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR014745 MHC class II, alpha/beta chain, N-terminal
InterPro IPR001003 MHC class II, alpha chain, N-terminal
Protein Ontology PR:000008612 HLA class II histocompatibility antigen, DO alpha chain
References
(Earliest) J:1569 Karlsson L, et al., The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex. J Exp Med. 1992 Aug 1;176(2):477-83
(Latest) J:190823 Gu Y, et al., Immunodeficiency and autoimmunity in h2-o-deficient mice. J Immunol. 2013 Jan 1;190(1):126-37
All references(39)
Other
accession IDs
MGD-MRK-10408, MGD-MRK-10520

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory