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H2-DMb2 Gene Detail
Summary
  • Symbol
    H2-DMb2
  • Name
    histocompatibility 2, class II, locus Mb2
  • Synonyms
    H-2Mb2, H2-Mb2, H2-M beta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95923
    NCBI Gene: 15000
  • Gene Overview
    MyGene.info: HLA-DMB
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34145416-34151095 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95923
protein coding gene Chr17:34143307-34151555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023559
protein coding gene Chr17:34125244-34137387 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0023486
protein coding gene Chr17:33371326-33378998 (+)
BALB/cJ MGP_BALBcJ_G0023525
protein coding gene Chr17:33125152-33137286 (+)
C3H/HeJ MGP_C3HHeJ_G0023286
protein coding gene Chr17:33708124-33735695 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023966
protein coding gene Chr17:35424220-35441711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021444
protein coding gene Chr17:30474823-30491775 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023264
protein coding gene Chr17:36854315-36889433 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0023358
protein coding gene Chr17:32189913-32206450 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0023381
protein coding gene Chr17:35862075-35870812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024008
protein coding gene Chr17:33703001-33715014 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022350
protein coding gene Chr17:31652202-31666078 (+)
WSB/EiJ MGP_WSBEiJ_G0022847
protein coding gene Chr17:33726278-33739695 (+)



Homology
more
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D6S221E, RING7
  • Links
    NCBI Gene ID: 3109
    neXtProt AC: NX_P28068
    UniProt: P28068

  • Chr Location
    6p21.32; chr6:32934629-32941070 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15000 NCBI Gene Model | MGI Sequence Detail 5680 C57BL/6J ±  kb
transcript NR_160895 RefSeq | MGI Sequence Detail 1509 C57BL/6  
polypeptide NP_034518 RefSeq | MGI Sequence Detail 261 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    18 Sequences
  • PDB
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR000353 MHC class II, beta chain, N-terminal
Molecular
Reagents
less
  • All nucleic 30
    Genomic 5
    cDNA 25

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10407, MGD-MRK-10519
References
more
  • Summaries
    All 30
    Gene Ontology 7
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory