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H2-DMb1 Gene Detail
Summary
  • Symbol
    H2-DMb1
  • Name
    histocompatibility 2, class II, locus Mb1
  • Synonyms
    H-2Mb1, H2-Mb1, H2-M beta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95922
    NCBI Gene: 14999
  • Gene Overview
    MyGene.info: HLA-DMB
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34153191-34160229 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95922
protein coding gene Chr17:34153072-34160230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023560
protein coding gene Chr17:34140008-34153355 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0023487
protein coding gene Chr17:33381425-33387337 (+)
BALB/cJ MGP_BALBcJ_G0023526
protein coding gene Chr17:33139839-33159395 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021445
protein coding gene Chr17:30484384-30491775 (+)
CAST/EiJ MGP_CASTEiJ_G0022786
protein coding gene Chr17:33830863-33840208 (+)
CBA/J MGP_CBAJ_G0023263
protein coding gene Chr17:36854145-36889595 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0023359
protein coding gene Chr17:32191626-32206123 (+)
LP/J MGP_LPJ_G0023470
protein coding gene Chr17:34423041-34429922 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0024009
protein coding gene Chr17:33716535-33722291 (+)
PWK/PhJ MGP_PWKPhJ_G0022536
protein coding gene Chr17:31267913-31284674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022351
protein coding gene Chr17:31655343-31674509 (+)
WSB/EiJ MGP_WSBEiJ_G0022846
protein coding gene Chr17:33726066-33739383 (+)



Homology
more
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HLA-DMB, major histocompatibility complex, class II, DM beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D6S221E, RING7
  • Links
    NCBI Gene ID: 3109
    neXtProt AC: NX_P28068
    UniProt: P28068

  • Chr Location
    6p21.32; chr6:32934629-32941070 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14999 NCBI Gene Model | MGI Sequence Detail 7039 C57BL/6J ±  kb
transcript NM_010387 RefSeq | MGI Sequence Detail 1284 C57BL/6  
polypeptide P35737 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000034662 class II histocompatibility antigen, M beta 1 chain
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR000353 MHC class II, beta chain, N-terminal
Molecular
Reagents
less
  • All nucleic 63
    Genomic 5
    cDNA 54
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10406, MGD-MRK-10518, MGI:2146833
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:11259 Cho S, et al., A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5197-201
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory