H2-M3 MGI Mouse Gene Detail - MGI:95915 - histocompatibility 2, M region locus 3

Symbol

H2-M3
Name

histocompatibility 2, M region locus 3
Synonyms

H-2M3, Hmt, R4B2

Feature Type

protein coding gene
IDs

MGI:95915
NCBI Gene: 14991
Gene Overview

MyGene.info: HLA-G
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:37270234-37274485 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.16 cM
Mapping Data

12 experiments

Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95915	protein coding gene	Chr17:37270220-37274485 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023706	protein coding gene	Chr17:37648165-37652451 (+)
A/J	MGP_AJ_G0023664	protein coding gene	Chr17:36501978-36506242 (+)
AKR/J	MGP_AKRJ_G0023635	protein coding gene	Chr17:36904650-36908936 (+)
BALB/cJ	MGP_BALBcJ_G0023670	protein coding gene	Chr17:36714666-36718930 (+)
C3H/HeJ	MGP_C3HHeJ_G0023433	protein coding gene	Chr17:37453379-37457665 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024108	protein coding gene	Chr17:39286750-39291014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021577	protein coding gene	Chr17:34268685-34272985 (+)
CAST/EiJ	MGP_CASTEiJ_G0022918	protein coding gene	Chr17:37577105-37581370 (+)
CBA/J	MGP_CBAJ_G0023410	protein coding gene	Chr17:40834422-40838708 (+)
DBA/2J	MGP_DBA2J_G0023535	protein coding gene	Chr17:35863619-35867883 (+)
FVB/NJ	MGP_FVBNJ_G0023508	protein coding gene	Chr17:35474325-35478589 (+)
LP/J	MGP_LPJ_G0023613	protein coding gene	Chr17:38209610-38213906 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023531	protein coding gene	Chr17:39597923-39602187 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024154	protein coding gene	Chr17:37272710-37276974 (+)
PWK/PhJ	MGP_PWKPhJ_G0022665	protein coding gene	Chr17:34636750-34641036 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022487	protein coding gene	Chr17:35358102-35362393 (+)
WSB/EiJ	MGP_WSBEiJ_G0022984	protein coding gene	Chr17:37618332-37622618 (+)

Human Ortholog

HLA-G, major histocompatibility complex, class I, G

Vertebrate Orthologs

5

Human Ortholog

HLA-G, major histocompatibility complex, class I, G
Orthology source: HomoloGene
Synonyms

MHC-G
Links

HGNC:4964

NCBI Gene ID: 3135

neXtProt AC: NX_P17693

UniProt: P17693
Chr Location

6p22.1; chr6:29826967-29831130 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 133255
1 human;1 mouse;1 rat;1 chimpanzee;1 macaque, rhesus
HCOP

human homology predictions: HLA-G
Protein SuperFamily

class I histocompatibility antigen
Gene Tree

H2-M3

Diseases

1 with human HLA-G associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 EFO:0000270 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

1
Transgenic

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

8 strains or lines available

At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.

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All GO Annotations

54
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

680
Tissues

23
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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H2-M3 interacts with 47 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS37617.1
UniGene

14437

Ensembl

ENSMUSG00000016206 (Evidence)
NCBI Gene

14991 (Evidence)

			Length	Strain/Species	Flank
genomic	14991	NCBI Gene Model \| MGI Sequence Detail	4252	C57BL/6J	± kb
transcript	NM_013819	RefSeq \| MGI Sequence Detail	1425	C57BL/6
polypeptide	NP_038847	RefSeq \| MGI Sequence Detail	336	C57BL/6

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UniProt

3 Sequences
PDB

1MHC
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR011162 MHC classes I/II-like antigen recognition protein

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains

IPR011161 MHC class I-like antigen recognition-like

IPR037055 MHC class I-like antigen recognition-like superfamily

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All nucleic 33

Genomic 13

cDNA 13

Primer pair 1

Other 6

Microarray probesets 4

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MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801

Summaries

All 55

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 12
Earliest

J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
Latest

J:272693 Linehan JL, et al., Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell. 2018 Feb 8;172(4):784-796.e18

TSS for H2-M3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144573	Chr17:37270214-37270249 (+)	-2 bp
Tssr144574	Chr17:37270255-37270260 (+)	24 bp
Tssr144575	Chr17:37270261-37270278 (+)	36 bp
Tssr144576	Chr17:37270520-37270536 (+)	294 bp
Tssr144577	Chr17:37270608-37270620 (+)	380 bp
Tssr144578	Chr17:37270670-37270696 (+)	449 bp
Tssr144579	Chr17:37270920-37270941 (+)	697 bp
Tssr144580	Chr17:37270958-37271024 (+)	757 bp
Tssr144581	Chr17:37271035-37271075 (+)	821 bp
Tssr144582	Chr17:37271082-37271115 (+)	865 bp
Tssr144583	Chr17:37271125-37271153 (+)	905 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/26/2020 MGI 6.15