H2-M3
Gene Detail

Symbol

Name
ID

H2-M3
histocompatibility 2, M region locus 3
MGI:95915

Synonyms

H-2M3, Hmt, R4B2

Feature Type

protein coding gene

Genetic Map

Chromosome 17
19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr17:37270220-37274484 bp, + strand From VEGA annotation of GRCm38   4265 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:133255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-M3

Human
homologs

Human Homolog		HLA-G, major histocompatibility complex, class I, G
NCBI Gene ID		3135
neXtProt AC		NX_P17693
Human Synonyms		MHC-G
Human Chr (Location)		6p21.3; chr6:29826979-29831122 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human HLA-G

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from APF )
 

At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.

 

Interactions

H2-M3 interacts with 47 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (28 annotations)

Process	alpha-beta T cell activation involved in immune response, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, ...
Component	external side of plasma membrane, membrane, ...
Function	peptide antigen binding, protein homodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (49)    Tissues (23)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	25
RT-PCR	24

cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(32) Genomic(13) cDNA(12) Primer pair(1) Other(6)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000037377 (Evidence)
Ensembl Gene Model	ENSMUSG00000016206 (Evidence)
Entrez Gene	14991 (Evidence)
UniGene	14437
DFCI	TC1586387, TC1654964
DoTS	DT.40151308, DT.94399781
NIA Mouse Gene Index	U017957
PDB	1MHC
Consensus CDS Project	CCDS37617.1
International Mouse Knockout Project Status	H2-M3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037377	VEGA Gene Model | MGI Sequence Detail	4265	C57BL/6J
transcript	OTTMUST00000096441	VEGA | MGI Sequence Detail	1438	Not Applicable
polypeptide	OTTMUSP00000054724	VEGA | MGI Sequence Detail	336	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(4) : SNPs within 2kb(112 from dbSNP Build 137)    SNPs within 2kb including multiple locations(114)

Protein-related
information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR011162	MHC classes I/II-like antigen recognition protein
InterPro	IPR001039	MHC class I, alpha chain, alpha1/alpha2
InterPro	IPR011161	MHC class I-like antigen recognition

References

(Earliest) J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
(Latest) J:190872 Andrews DM, et al., Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nat Immunol. 2012 Dec;13(12):1171-7
All references(51)

Other
accession IDs

MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801