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H2-M3
Gene Detail
Symbol

Name
ID
H2-M3
histocompatibility 2, M region locus 3
MGI:95915
Synonyms
H-2M3, Hmt, R4B2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:37270220-37274484 bp, + strand
From VEGA annotation of GRCm38

  4265 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: HLA-G
Protein SuperFamily: class I histocompatibility antigen
Gene Tree: H2-M3

Human
homologs
HLA-G, major histocompatibility complex, class I, G
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3135
neXtProt AC: NX_P17693

Human Synonyms: MHC-G

Human Chr (Location): 6p21.3; chr6:29826979-29831122 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HLA-G

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from APF , CvDC )
 
At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.
 
Interactions
H2-M3 interacts with 47 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (49)    Tissues (23)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 24
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(13) cDNA(12) Primer pair(1) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037377 (Evidence)
Ensembl Gene Model ENSMUSG00000016206 (Evidence)
Entrez Gene 14991 (Evidence)
UniGene 14437
DFCI TC1586387, TC1654964
DoTS DT.40151308, DT.94399781
NIA Mouse Gene Index U017957
PDB 1MHC
Consensus CDS Project CCDS37617.1
International Mouse Phenotyping Consortium Status H2-M3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037377 VEGA Gene Model | MGI Sequence Detail 4265 C57BL/6J ±  kb
transcript OTTMUST00000096441 VEGA | MGI Sequence Detail 1438 Not Applicable 
polypeptide OTTMUSP00000054724 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(112 from dbSNP Build 137)    SNPs within 2kb including multiple locations(114)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
References
(Earliest) J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
(Latest) J:190872 Andrews DM, et al., Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nat Immunol. 2012 Dec;13(12):1171-7
All references(49)
Other
accession IDs
MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory