H2-M3 MGI Mouse Gene Detail - MGI:95915 - histocompatibility 2, M region locus 3

H2-M3 Gene Detail

Symbol

H2-M3
Name

histocompatibility 2, M region locus 3
Synonyms

H-2M3, Hmt, R4B2

Feature Type

protein coding gene
IDs

MGI:95915
NCBI Gene: 14991
Gene Overview

MyGene.info: HLA-G

Sequence Map

Chr17:37270220-37274484 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4265 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.16 cM
Mapping Data

12 experiments

Human Ortholog

HLA-G, major histocompatibility complex, class I, G

Vertebrate Orthologs

5

Human Ortholog

HLA-G, major histocompatibility complex, class I, G
Orthology source: HomoloGene, HGNC
Synonyms

MHC-G
Links

HGNC:4964

NCBI Gene ID: 3135

neXtProt AC: NX_P17693
Chr Location

6p21.3; chr6:29826979-29831122 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 133255
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque
HCOP

human homology predictions: HLA-G
Protein SuperFamily

class I histocompatibility antigen
Gene Tree

H2-M3

Diseases

1 with human HLA-G associations

				Human Disease	Mouse Models
				Asthma, Susceptibility to OMIM: 600807

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

1
Transgenic

1
Incidental Mutations

APF , CvDC

At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.

less

All GO Annotations

28
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

49
Tissues

23
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

less

H2-M3 interacts with 47 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

less

All Sequences

22
RefSeq

2
UniProt

3
CCDS

CCDS37617.1
UniGene

14437

			Length	Strain/Species	Flank
genomic	OTTMUSG00000037377	VEGA Gene Model \| MGI Sequence Detail	4265	C57BL/6J	± kb
transcript	OTTMUST00000096441	VEGA \| MGI Sequence Detail	1438	Not Applicable
polypeptide	OTTMUSP00000054724	VEGA \| MGI Sequence Detail	336	Not Applicable

less

RFLP

4

less

UniProt

3 Sequences
PDB

1MHC
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR011162 MHC classes I/II-like antigen recognition protein

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains

IPR011161 MHC class I-like antigen recognition-like

less

All nucleic 32

Genomic 13

cDNA 12

Primer pair 1

Other 6

Microarray probesets 4

less

MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 9
Earliest

J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
Latest

J:225528 Liu J, et al., Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. Neurochem Res. 2015 Jul;40(7):1487-96

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/20/2016 MGI 6.05