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H2-M3 Gene Detail
Summary
  • Symbol
    H2-M3
  • Name
    histocompatibility 2, M region locus 3
  • Synonyms
    H-2M3, Hmt, R4B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95915
    NCBI Gene: 14991
  • Gene Overview
    MyGene.info: HLA-G
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37270234-37274485 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95915
 protein coding gene Chr17:37270220-37274485 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023706
 protein coding gene Chr17:37648165-37652451 (+)
A/J MGP_AJ_G0023664
 protein coding gene Chr17:36501978-36506242 (+)
AKR/J MGP_AKRJ_G0023635
 protein coding gene Chr17:36904650-36908936 (+)
BALB/cJ MGP_BALBcJ_G0023670
 protein coding gene Chr17:36714666-36718930 (+)
C3H/HeJ MGP_C3HHeJ_G0023433
 protein coding gene Chr17:37453379-37457665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024108
 protein coding gene Chr17:39286750-39291014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021577
 protein coding gene Chr17:34268685-34272985 (+)
CAST/EiJ MGP_CASTEiJ_G0022918
 protein coding gene Chr17:37577105-37581370 (+)
CBA/J MGP_CBAJ_G0023410
 protein coding gene Chr17:40834422-40838708 (+)
DBA/2J MGP_DBA2J_G0023535
 protein coding gene Chr17:35863619-35867883 (+)
FVB/NJ MGP_FVBNJ_G0023508
 protein coding gene Chr17:35474325-35478589 (+)
LP/J MGP_LPJ_G0023613
 protein coding gene Chr17:38209610-38213906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023531
 protein coding gene Chr17:39597923-39602187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024154
 protein coding gene Chr17:37272710-37276974 (+)
PWK/PhJ MGP_PWKPhJ_G0022665
 protein coding gene Chr17:34636750-34641036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022487
 protein coding gene Chr17:35358102-35362393 (+)
WSB/EiJ MGP_WSBEiJ_G0022984
 protein coding gene Chr17:37618332-37622618 (+)



Homology
more
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Vertebrate Orthologs
    5
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
    Orthology source: HomoloGene
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826967-29831130 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human HLA-G associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    52
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    23
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14991 NCBI Gene Model | MGI Sequence Detail 4252 C57BL/6J ±  kb
    transcript NM_013819 RefSeq | MGI Sequence Detail 1425 C57BL/6  
    polypeptide NP_038847 RefSeq | MGI Sequence Detail 336 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • PDB
      1MHC
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 13
      cDNA 13
      Primer pair 1
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
    • Latest
      J:301468 Tanoue T, et al., A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019 Jan;565(7741):600-605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/06/2021
    MGI 6.16     		The Jackson Laboratory