Slc39a7 MGI Mouse Gene Detail - MGI:95909 - solute carrier family 39 (zinc transporter), member 7

Slc39a7 Gene Detail

Symbol

Slc39a7
Name

solute carrier family 39 (zinc transporter), member 7
Synonyms

H-2Ke4, H2-Ke4, Ke-4, KE4, Ring5, Zip7

Feature Type

protein coding gene
IDs

MGI:95909
NCBI Gene: 14977
Gene Overview

MyGene.info: SLC39A7
Alliance

gene page

Sequence Map

Chr17:34028269-34031682 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

3414 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

5 experiments

Human Ortholog

SLC39A7, solute carrier family 39 member 7

Vertebrate Orthologs

9

Human Ortholog

SLC39A7, solute carrier family 39 member 7
Orthology source: HomoloGene, HGNC
Synonyms

D6S115E, D6S2244E, H2-KE4, HKE4, KE4, RING5, ZIP7
Links

HGNC:4927

NCBI Gene ID: 7922

neXtProt AC: NX_Q92504

UniProt: Q92504
Chr Location

6p21.32; chr6:33200826-33204437 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5072
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC39A7
Gene Tree

Slc39a7

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Slc39a7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a conditional allele activated in intestinal epithelial cells exhibit premature death, loss of epithelial integrity, reduced enterocyte proliferation and increased enterocyte apoptosis.

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All GO Annotations

15
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

198
Tissues

57
cDNA Data

183
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a7

ZFIN slc39a7

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Slc39a7 interacts with 52 markers (Mir34a, Mir34b, Mir34c, ...) View All

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All Sequences

51
RefSeq

4
UniProt

4
CCDS

CCDS37576.1
UniGene

18556

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035430	VEGA Gene Model \| MGI Sequence Detail	3414	C57BL/6J	± kb
transcript	OTTMUST00000090595	VEGA \| MGI Sequence Detail	2244	Not Applicable
polypeptide	OTTMUSP00000049736	VEGA \| MGI Sequence Detail	476	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015134 zinc transporter SLC39A7

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 198

Genomic 10

cDNA 186

Primer pair 2

Microarray probesets 2

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MGD-MRK-10394, MGD-MRK-10505, MGI:2146748, MGI:2146797, MGI:2146956

Summaries

All 53

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 10
Earliest

J:9525 Abe K, et al., Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos. EMBO J. 1988 Nov;7(11):3441-9
Latest

J:244716 Bin BH, et al., Requirement of Zinc Transporter SLC39A7/ZIP7 for Dermal Development to Fine-Tune Endoplasmic Reticulum Function by Regulating Protein Disulfide Isomerase. J Invest Dermatol. 2017 Aug;137(8):1682-1691

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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