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Guk1 Gene Detail
Summary
  • Symbol
    Guk1
  • Name
    guanylate kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95871
    NCBI Gene: 14923
  • Gene Overview
    MyGene.info: GUK1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:59183875-59192212 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95871
protein coding gene Chr11:59183855-59192212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018390
protein coding gene Chr11:58991202-58999484 (-)
A/J MGP_AJ_G0018359
protein coding gene Chr11:56737348-56745636 (-)
AKR/J MGP_AKRJ_G0018329
protein coding gene Chr11:58642173-58650639 (-)
BALB/cJ MGP_BALBcJ_G0018330
protein coding gene Chr11:57099888-57108172 (-)
C3H/HeJ MGP_C3HHeJ_G0018143
protein coding gene Chr11:58526130-58534460 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018782
protein coding gene Chr11:60873225-60881563 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016427
protein coding gene Chr11:53999343-54007593 (-)
CAST/EiJ MGP_CASTEiJ_G0017701
protein coding gene Chr11:58641787-58650069 (-)
CBA/J MGP_CBAJ_G0018117
protein coding gene Chr11:63523021-63531302 (-)
DBA/2J MGP_DBA2J_G0018226
protein coding gene Chr11:56418941-56427218 (-)
FVB/NJ MGP_FVBNJ_G0018217
protein coding gene Chr11:56060686-56068958 (-)
LP/J MGP_LPJ_G0018299
protein coding gene Chr11:59596121-59604287 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018241
protein coding gene Chr11:64673037-64681316 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018823
protein coding gene Chr11:58661046-58670840 (-)
PWK/PhJ MGP_PWKPhJ_G0017471
protein coding gene Chr11:56998366-57006850 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017264
protein coding gene Chr11:58458116-58466428 (-)
WSB/EiJ MGP_WSBEiJ_G0017751
protein coding gene Chr11:58350773-58360072 (-)



Homology
more
  • Human Ortholog
    GUK1, guanylate kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUK1, guanylate kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GMK
  • Links
    NCBI Gene ID: 2987
    neXtProt AC: NX_Q16774
    UniProt: Q16774

  • Chr Location
    1q42.13; chr1:228139643-228148955 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020444 Ensembl Gene Model | MGI Sequence Detail 8338 C57BL/6J ±  kb
transcript ENSMUST00000170202 Ensembl | MGI Sequence Detail 1078 Not Applicable  
polypeptide ENSMUSP00000127566 Ensembl | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • PDB
  • EC
  • InterPro Domains
    IPR017665 Guanylate kinase
    IPR020590 Guanylate kinase, conserved site
    IPR008144 Guanylate kinase-like domain
    IPR008145 Guanylate kinase/L-type calcium channel beta subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 101
    cDNA 99
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10331, MGD-MRK-10332, MGI:2143999, MGI:2144357, MGI:2144358, MGI:2144452
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:229930 Nechiporuk T, et al., The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory