Gss
Gene Detail

Symbol Name ID

Gss glutathione synthetase MGI:95852

Synonyms

GS-A/GS-B

Feature Type

protein coding gene

Genetic Map

Chromosome 2

77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:155563181-155592810 bp, - strand From VEGA annotation of GRCm38   29630 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutathione synthase
Gene Tree: Gss

Human homologs

Human Homolog		GSS, glutathione synthetase
NCBI Gene ID		2937
neXtProt AC		NX_P48637
Human Synonyms		GSHS
Human Chr (Location)		20q11.2; chr20:33516236-33543601 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GSS

Alleles and phenotypes

All alleles(50) : Targeted(3) Gene trapped(47)
 

Mice homozygous for a null mutation all die before E7.5.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	glutathione biosynthetic process, response to cadmium ion
Function	ATP binding, glutathione binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (96)    Images (37)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	119

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(22) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016106 (Evidence)
Ensembl Gene Model	ENSMUSG00000027610 (Evidence)
Entrez Gene	14854 (Evidence)
DFCI	TC1574870, TC1645956, TC1765432
DoTS	DT.103568703, DT.110701647, DT.493635, DT.94405316
EC	6.3.2.3
Consensus CDS Project	CCDS16951.1
International Mouse Knockout Project Status	Gss

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016106	VEGA Gene Model | MGI Sequence Detail	29630	C57BL/6J
transcript	OTTMUST00000038479	VEGA | MGI Sequence Detail	1963	Not Applicable
polypeptide	OTTMUSP00000017226	VEGA | MGI Sequence Detail	474	Not Applicable

All sequences(63) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(216 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR014042	Glutathione synthase, alpha-helical, eukaryotic
InterPro	IPR005615	Glutathione synthase, eukaryotic
InterPro	IPR014049	Glutathione synthase, N-terminal, eukaryotic
InterPro	IPR004887	Glutathione synthase, substrate-binding, eukaryotic
InterPro	IPR016185	Pre-ATP-grasp fold
Protein Ontology	PR:000008293	glutathione synthetase

References

(Earliest) J:34320 Shi ZZ, et al., A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch Biochem Biophys. 1996 Jul 15;331(2):215-24
(Latest) J:175759 Winkler A, et al., Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse. Biochem Biophys Res Commun. 2011 Aug 19;412(1):121-6
All references(39)

Other accession IDs

MGD-MRK-10303, MGI:2138886