About   Help   FAQ
Gss Gene Detail
Summary
  • Symbol
    Gss
  • Name
    glutathione synthetase
  • Synonyms
    GS-A/GS-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95852
    NCBI Gene: 14854
Location & Maps
more
  • Sequence Map
    Chr2:155563181-155592810 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GSS, glutathione synthetase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSS, glutathione synthetase
    Orthology source: HomoloGene
  • Synonyms
    GSHS, HEL-S-64p, HEL-S-88n
  • Links
    NCBI Gene ID: 2937
    neXtProt AC: NX_P48637

  • Chr Location
    20q11.2; chr20:34928433-34955992 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human GSS associations

Human Disease Mouse Models
       Glutathione Synthetase Deficiency of Erythrocytes, Hemolytic Anemia Due To; GSSDE   OMIM: 231900
Glutathione Synthetase Deficiency; GSSD   OMIM: 266130
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    47
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null mutation all die before E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016106 VEGA Gene Model | MGI Sequence Detail 29630 C57BL/6J ±  kb
transcript OTTMUST00000038479 VEGA | MGI Sequence Detail 1963 Not Applicable  
polypeptide OTTMUSP00000017226 VEGA | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    282 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008293 glutathione synthetase
  • EC
  • InterPro Domains
    IPR014042 Glutathione synthase, alpha-helical, eukaryotic
    IPR014709 Glutathione synthase domain
    IPR005615 Glutathione synthase, eukaryotic
    IPR014049 Glutathione synthase, N-terminal, eukaryotic
    IPR004887 Glutathione synthase, substrate-binding, eukaryotic
    IPR016185 Pre-ATP-grasp domain
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 22
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10303, MGI:2138886
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:34320 Shi ZZ, et al., A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch Biochem Biophys. 1996 Jul 15;331(2):215-24
  • Latest
    J:175759 Winkler A, et al., Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse. Biochem Biophys Res Commun. 2011 Aug 19;412(1):121-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory