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Gss
Gene Detail
Symbol

Name
ID
Gss
glutathione synthetase
MGI:95852
Synonyms
GS-A/GS-B
Feature Type
protein coding gene
Genetic Map
Chromosome 2
77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:155563181-155592810 bp, - strand
From VEGA annotation of GRCm38

  29630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GSS
Protein SuperFamily: glutathione synthase
Gene Tree: Gss

Human
homologs
GSS, glutathione synthetase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2937
neXtProt AC: NX_P48637

Human Synonyms: GSHS, HEL-S-64p, HEL-S-88n

Human Chr (Location): 20q11.2; chr20:34928433-34955992 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GSS

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(47) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation all die before E7.5.
 
Interactions
Gss interacts with 79 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process glutathione biosynthetic process, response to cadmium ion
Component extracellular exosome
Function ATP binding, glutathione binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (165)    Tissues (142)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 165
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gss ; ZFIN gss    NEW 
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(22) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016106 (Evidence)
Ensembl Gene Model ENSMUSG00000027610 (Evidence)
Entrez Gene 14854 (Evidence)
DFCI TC1574870, TC1645956, TC1765432
DoTS DT.103568703, DT.110701647, DT.493635, DT.94405316
EC 6.3.2.3
Consensus CDS Project CCDS16951.1, CCDS71167.1
International Mouse Phenotyping Consortium Status Gss
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016106 VEGA Gene Model | MGI Sequence Detail 29630 C57BL/6J ±  kb
transcript OTTMUST00000038479 VEGA | MGI Sequence Detail 1963 Not Applicable 
polypeptide OTTMUSP00000017226 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014042 Glutathione synthase, alpha-helical, eukaryotic
InterPro IPR014709 Glutathione synthase domain
InterPro IPR005615 Glutathione synthase, eukaryotic
InterPro IPR014049 Glutathione synthase, N-terminal, eukaryotic
InterPro IPR004887 Glutathione synthase, substrate-binding, eukaryotic
InterPro IPR016185 Pre-ATP-grasp domain
Protein Ontology PR:000008293 glutathione synthetase
References
(Earliest) J:34320 Shi ZZ, et al., A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch Biochem Biophys. 1996 Jul 15;331(2):215-24
(Latest) J:175759 Winkler A, et al., Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse. Biochem Biophys Res Commun. 2011 Aug 19;412(1):121-6
All references(38)
Other
accession IDs
MGD-MRK-10303, MGI:2138886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory