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Gsx1 Gene Detail
Summary
  • Symbol
    Gsx1
  • Name
    GS homeobox 1
  • Synonyms
    Gsh1, Gsh-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95842
    NCBI Gene: 14842
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:147188696-147190947 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2252 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.79 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GSX1, GS homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSX1, GS homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gsh-1, GSH1
  • Links
    NCBI Gene ID: 219409
    neXtProt AC: NX_Q9H4S2
    UniProt: Q9H4S2

  • Chr Location
    13q12.2; chr13:27792643-27793952 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17092
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial neonatal and peri-weaning lethality, delayed eyelid opening, dwarfism, multiple hormone deficiencies, aberrant pituitary development, hypothalamic dysfunction, altered bone epiphyseal growth plates, low WBC counts, infertility and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024587 VEGA Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
    transcript OTTMUST00000060402 VEGA | MGI Sequence Detail 1773 Not Applicable  
    polypeptide OTTMUSP00000029462 VEGA | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      38 from dbSNP Build 142
    • RFLP
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 14
      Genomic 1
      cDNA 7
      Primer pair 2
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10284, MGD-MRK-10289
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 39
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
    • Latest
      J:252112 Kim JJ, et al., Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15. Dev Dyn. 2018 Jan;247(1):156-169

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory