About   Help   FAQ
Gsx1 Gene Detail
Summary
  • Symbol
    Gsx1
  • Name
    GS homeobox 1
  • Synonyms
    Gsh1, Gsh-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95842
    NCBI Gene: 14842
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147188696-147190947 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95842
protein coding gene Chr5:147188696-147190947 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030385
protein coding gene Chr5:152826961-152829197 (+)
A/J MGP_AJ_G0030358
protein coding gene Chr5:146356406-146359159 (+)
AKR/J MGP_AKRJ_G0030285
protein coding gene Chr5:150854486-150856729 (+)
BALB/cJ MGP_BALBcJ_G0030367
protein coding gene Chr5:147568791-147571038 (+)
C3H/HeJ MGP_C3HHeJ_G0030081
protein coding gene Chr5:151820353-151822605 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030822
protein coding gene Chr5:158420828-158425531 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028035
protein coding gene Chr5:140774020-140776296 (+)
CAST/EiJ MGP_CASTEiJ_G0029483
protein coding gene Chr5:151373198-151375474 (+)
CBA/J MGP_CBAJ_G0030059
protein coding gene Chr5:165030434-165033485 (+)
DBA/2J MGP_DBA2J_G0030203
protein coding gene Chr5:146035642-146039481 (+)
FVB/NJ MGP_FVBNJ_G0030157
protein coding gene Chr5:145235578-145238260 (+)
LP/J MGP_LPJ_G0030290
protein coding gene Chr5:153529475-153531580 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030193
protein coding gene Chr5:167320233-167322492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030852
protein coding gene Chr5:150755183-150758371 (+)
PWK/PhJ MGP_PWKPhJ_G0029197
protein coding gene Chr5:145119392-145121993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029033
protein coding gene Chr5:148083509-148085847 (+)
WSB/EiJ MGP_WSBEiJ_G0029560
protein coding gene Chr5:151550057-151554548 (+)



Homology
more
  • Human Ortholog
    GSX1, GS homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GSX1, GS homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gsh-1, GSH1
  • Links
    NCBI Gene ID: 219409
    neXtProt AC: NX_Q9H4S2
    UniProt: Q9H4S2

  • Chr Location
    13q12.2; chr13:27792643-27793952 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17092
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial neonatal and peri-weaning lethality, delayed eyelid opening, dwarfism, multiple hormone deficiencies, aberrant pituitary development, hypothalamic dysfunction, altered bone epiphyseal growth plates, low WBC counts, infertility and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14842 NCBI Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
    transcript NM_008178 RefSeq | MGI Sequence Detail 1773 C57BL/6  
    polypeptide P31315 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 8
      Primer pair 2
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10284, MGD-MRK-10289
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 44
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
    • Latest
      J:268511 Fujiyama T, et al., Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain. Cell Rep. 2018 Jul 3;24(1):79-94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/12/2019
    MGI 6.14
    The Jackson Laboratory