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Gsx1
Gene Detail
Symbol

Name
ID
Gsx1
GS homeobox 1
MGI:95842
Synonyms
Gsh1, Gsh-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
86.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:147188696-147190947 bp, + strand
From VEGA annotation of GRCm38

  2252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gsx1

Human
homologs
Human Homolog GSX1, GS homeobox 1
NCBI Gene ID 219409
neXtProt AC  NX_Q9H4S2
Human Synonyms  Gsh-1, GSH1
Human Chr (Location)  13q12.2; chr13:27792643-27793952 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show partial neonatal and peri-weaning lethality, delayed eyelid opening, dwarfism, multiple hormone deficiencies, aberrant pituitary development, hypothalamic dysfunction, altered bone epiphyseal growth plates, low WBC counts, infertility and premature death.
 
Interactions
Gsx1 interacts with 97 markers (Mir1b, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adenohypophysis development, hypothalamus development, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (243)    Tissues (202)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
RT-PCR 46
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(6) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024587 (Evidence)
Ensembl Gene ModelENSMUSG00000053129 (Evidence)
Entrez Gene14842 (Evidence)
UniGene4797
DoTSDT.87055486
Consensus CDS ProjectCCDS19877.1
International Mouse Knockout Project StatusGsx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024587 VEGA Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
transcript OTTMUST00000060402 VEGA | MGI Sequence Detail 1773 Not Applicable 
polypeptide OTTMUSP00000029462 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008308 GS homeobox 1
References
(Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:196218 Wang B, et al., Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 1;521(7):1561-84
All references(67)
Other
accession IDs
MGD-MRK-10284, MGD-MRK-10289

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory