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Hspa5 Gene Detail
Summary
  • Symbol
    Hspa5
  • Name
    heat shock protein 5
  • Synonyms
    78kDa, baffled, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, mBiP, Sez7, XAP-1 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95835
    NCBI Gene: 14828
  • Gene Overview
    MyGene.info: HSPA5
Location & Maps
more
  • Sequence Map
    Chr2:34771970-34777547 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.94 cM
  • Mapping Data
    25 experiments
Homology
more
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
    Orthology source: HomoloGene
  • Synonyms
    BIP, GRP78, HEL-S-89n, MIF2
  • Links
    NCBI Gene ID: 3309
    neXtProt AC: NX_P11021

  • Chr Location
    9q33.3; chr9:125234848-125241387 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Gene trapped
    9
  • Targeted
    6
  • Incidental Mutations
Nullizygous embryos die around implantation. Neonates homozygous for a knock-in allele die of respiratory failure. Mice homozygous for an ENU-induced mutation exhibit abnormal thalamocortical axon patterning, small kidneys, cleft palate, respiratory distress, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012014 VEGA Gene Model | MGI Sequence Detail 5578 C57BL/6J ±  kb
transcript OTTMUST00000028494 VEGA | MGI Sequence Detail 2613 Not Applicable  
polypeptide OTTMUSP00000012896 VEGA | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000008810 78 kDa glucose-regulated protein
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain
    IPR029047 Heat shock protein 70kD, peptide-binding domain
Molecular
Reagents
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  • All nucleic 51
    Genomic 1
    cDNA 39
    Primer pair 10
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10275, MGD-MRK-10943, MGD-MRK-1560, MGD-MRK-34244, MGD-MRK-35815, MGI:106550, MGI:107349, MGI:2139125, MGI:2139181, MGI:4889058
References
more
  • Summaries
    All 188
    Developmental Gene Expression 68
    Gene Ontology 30
    Phenotypes 28
  • Earliest
    J:8823 Ting J, et al., The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat. Gene. 1987;55(1):147-52
  • Latest
    J:231537 Wilkin RJ, et al., Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease. Am J Pathol. 2016 Apr;186(4):748-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory