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Hspa5 Gene Detail
Summary
  • Symbol
    Hspa5
  • Name
    heat shock protein 5
  • Synonyms
    78kDa, baffled, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, mBiP, Sez7, XAP-1 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95835
    NCBI Gene: 14828
  • Gene Overview
    MyGene.info: HSPA5
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34772090-34776529 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.94 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95835
protein coding gene Chr2:34771970-34777547 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025640
protein coding gene Chr2:33377615-33383192 (+)
A/J MGP_AJ_G0025617
protein coding gene Chr2:31960650-31966227 (+)
AKR/J MGP_AKRJ_G0025587
protein coding gene Chr2:33088766-33094343 (+)
BALB/cJ MGP_BALBcJ_G0025614
protein coding gene Chr2:32070642-32076219 (+)
C3H/HeJ MGP_C3HHeJ_G0025374
protein coding gene Chr2:32979212-32984789 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026058
protein coding gene Chr2:34346327-34353321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023467
protein coding gene Chr2:30658585-30664087 (+)
CAST/EiJ MGP_CASTEiJ_G0024836
protein coding gene Chr2:32973973-32982185 (+)
CBA/J MGP_CBAJ_G0025352
protein coding gene Chr2:35677039-35682616 (+)
DBA/2J MGP_DBA2J_G0025485
protein coding gene Chr2:31732997-31738574 (+)
FVB/NJ MGP_FVBNJ_G0025447
protein coding gene Chr2:31624019-31629596 (+)
LP/J MGP_LPJ_G0025571
protein coding gene Chr2:33294941-33300518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025478
protein coding gene Chr2:35194028-35199605 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026116
protein coding gene Chr2:32980000-32985603 (+)
PWK/PhJ MGP_PWKPhJ_G0024584
protein coding gene Chr2:31645336-31651027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024384
protein coding gene Chr2:33139527-33144953 (+)
WSB/EiJ MGP_WSBEiJ_G0024905
protein coding gene Chr2:33154992-33160572 (+)



Homology
more
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIP, GRP78, HEL-S-89n, MIF2
  • Links
    NCBI Gene ID: 3309
    neXtProt AC: NX_P11021
    UniProt: P11021

  • Chr Location
    9q33.3; chr9:125234848-125241387 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    58 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous embryos die around implantation. Neonates homozygous for a knock-in allele die of respiratory failure. Mice homozygous for an ENU-induced mutation exhibit abnormal thalamocortical axon patterning, small kidneys, cleft palate, respiratory distress, and postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14828 NCBI Gene Model | MGI Sequence Detail 4440 C57BL/6J ±  kb
    transcript NM_022310 RefSeq | MGI Sequence Detail 2616 C57BL/6  
    polypeptide P20029 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 40
      Primer pair 10
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10275, MGD-MRK-10943, MGD-MRK-1560, MGD-MRK-34244, MGD-MRK-35815, MGI:106550, MGI:107349, MGI:2139125, MGI:2139181, MGI:4889058
    References
    more
    • Summaries
      All 248
      Developmental Gene Expression 83
      Gene Ontology 39
      Phenotypes 32
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:265909 Zhang F, et al., cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9449-E9458

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory