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Grp Gene Detail
Summary
  • Symbol
    Grp
  • Name
    gastrin releasing peptide
  • Synonyms
    BLP, MGC:37475
  • Feature Type
    protein coding gene
  • IDs
    MGI:95833
    NCBI Gene: 225642
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:66005891-66019667 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 38.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95833
protein coding gene Chr18:66005826-66019670 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024512
protein coding gene Chr18:66034359-66050083 (+)
A/J MGP_AJ_G0024479
protein coding gene Chr18:63164651-63178824 (+)
AKR/J MGP_AKRJ_G0024449
protein coding gene Chr18:64951870-64965516 (+)
BALB/cJ MGP_BALBcJ_G0024478
protein coding gene Chr18:63306094-63321305 (+)
C3H/HeJ MGP_C3HHeJ_G0024246
protein coding gene Chr18:65156897-65172449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024925
protein coding gene Chr18:67790026-67803707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022356
protein coding gene Chr18:62611333-62625409 (+)
CAST/EiJ MGP_CASTEiJ_G0023719
protein coding gene Chr18:65159052-65174247 (+)
CBA/J MGP_CBAJ_G0024216
protein coding gene Chr18:70042008-70056084 (+)
DBA/2J MGP_DBA2J_G0024346
protein coding gene Chr18:62833222-62847138 (+)
FVB/NJ MGP_FVBNJ_G0024312
protein coding gene Chr18:62215894-62229693 (+)
LP/J MGP_LPJ_G0024430
protein coding gene Chr18:65888774-65906222 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024341
protein coding gene Chr18:71430209-71444981 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024972
protein coding gene Chr18:65156123-65172222 (+)
PWK/PhJ MGP_PWKPhJ_G0023462
protein coding gene Chr18:63083871-63097836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023267
protein coding gene Chr18:65320377-65334005 (+)
WSB/EiJ MGP_WSBEiJ_G0023783
protein coding gene Chr18:65020213-65036595 (+)



Homology
more
  • Human Ortholog
    GRP, gastrin releasing peptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRP, gastrin releasing peptide
  • Synonyms
    BN, GRP-10, preproGRP, proGRP
  • Links
    NCBI Gene ID: 2922
    neXtProt AC: NX_P07492
    UniProt: P07492

  • Chr Location
    18q21.32; chr18:59219189-59230774 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit attenuated scratching response to chloroquine, SLIGRL and BAM8-22.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024517 Ensembl Gene Model | MGI Sequence Detail 13777 C57BL/6J ±  kb
    transcript ENSMUST00000173985 Ensembl | MGI Sequence Detail 969 Not Applicable  
    polypeptide ENSMUSP00000133437 Ensembl | MGI Sequence Detail 146 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10273
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 22
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:15302 Spindel ER, et al., Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5699-703
    • Latest
      J:332369 Liau ES, et al., Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons. Nat Commun. 2023 Jan 3;14(1):46

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory