Grp MGI Mouse Gene Detail - MGI:95833 - gastrin releasing peptide

Symbol

Grp
Name

gastrin releasing peptide
Synonyms

BLP, MGC:37475

Feature Type

protein coding gene
IDs

MGI:95833
NCBI Gene: 225642
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:66005891-66019667 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 38.98 cM
Mapping Data

2 experiments

SNPs within 2kb

547 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95833	protein coding gene	Chr18:66005826-66019670 (+)
129S1/SvImJ	ENSMUSG00200023175	protein coding gene	Chr18:63192205-63205981 (+)
A/J	ENSMUSG00195029423	protein coding gene	Chr18:63231264-63245105 (+)
AKR/J	ENSMUSG00220021568	protein coding gene	Chr18:63198091-63211863 (+)
BALB/cJ	ENSMUSG00180011177	protein coding gene	Chr18:63798258-63812098 (+)
C3H/HeJ	ENSMUSG00175009665	protein coding gene	Chr18:63404746-63418527 (+)
C57BL/6NJ	ENSMUSG00215011158	protein coding gene	Chr18:62746653-62760437 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022356	protein coding gene	Chr18:62611333-62625409 (+)
CAST/EiJ	ENSTCUG00005013990	protein coding gene	Chr18:62407336-62421104 (+)
CBA/J	ENSMUSG00210027132	protein coding gene	Chr18:63362452-63376229 (+)
DBA/2J	ENSMUSG00185028075	protein coding gene	Chr18:63273468-63287244 (+)
FVB/NJ	ENSMUSG00205010262	protein coding gene	Chr18:62741120-62754888 (+)
JF1/MsJ	ENSUMUG00000017850	protein coding gene	Chr18:63170409-63184179 (+)
LP/J	ENSMUSG00230037115	protein coding gene	Chr18:65325372-65339145 (+)
NOD/ShiLtJ	ENSMUSG00190008037	protein coding gene	Chr18:63000464-63014228 (+)
NZO/HlLtJ	ENSMUSG00225029561	protein coding gene	Chr18:65210748-65224535 (+)
PWK/PhJ	ENSLUMG00010025038	protein coding gene	Chr18:63567296-63581067 (+)
SPRET/EiJ	ENSMSPG00010031981	protein coding gene	Chr18:63713285-63726781 (+)
WSB/EiJ	ENSIUOG00005005895	protein coding gene	Chr18:62797291-62811046 (+)

Human Ortholog

GRP, gastrin releasing peptide

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRP, gastrin releasing peptide
Synonyms

BN, GRP-10, preproGRP, proGRP
Links

HGNC:4605

NCBI Gene ID: 2922

UniProt: P07492
Chr Location

18q21.32; chr18:59219189-59230774 (+) GRCh38

MGI Vertebrate Homology

Grp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GRP
Gene Tree

Grp

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

11
Gene trapped

7
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit attenuated scratching response to chloroquine, SLIGRL and BAM8-22.

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All GO Annotations

32
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

130
cDNA Data

8
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grp

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All Sequences

40
RefSeq

6
UniProt

1
CCDS

CCDS29310.1

Ensembl

ENSMUSG00000024517 (Evidence)
NCBI Gene

225642

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024517	Ensembl Gene Model \| MGI Sequence Detail	13777	C57BL/6J	± kb
transcript	ENSMUST00000173985	Ensembl \| MGI Sequence Detail	969	Not Applicable
polypeptide	ENSMUSP00000133437	Ensembl \| MGI Sequence Detail	146	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031729 gastrin-releasing peptide

(term hierarchy)
InterPro Domains

IPR000874 Bombesin/neuromedin-B/ranatensin peptide family

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All nucleic 15

cDNA 9

Primer pair 3

Other 3

Antibodies 1

Microarray probesets 3

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MGD-MRK-10273

Summaries

All 95

Developmental Gene Expression 25

Gene Ontology 13

Phenotypes 29
Earliest

J:15302 Spindel ER, et al., Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5699-703
Latest

J:382373 Zhou H, et al., Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus. Commun Biol. 2026 Feb 12;9(1)

TSS for Grp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151704	Chr18:66006549-66006566 (+)	667 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24