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Grp Gene Detail
Summary
  • Symbol
    Grp
  • Name
    gastrin releasing peptide
  • Synonyms
    BLP, MGC:37475
  • Feature Type
    protein coding gene
  • IDs
    MGI:95833
    NCBI Gene: 225642
  • Gene Overview
    MyGene.info: GRP
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65872820-65886579 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 38.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95833
protein coding gene Chr18:65872746-65886599 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024512
protein coding gene Chr18:66034359-66050083 (+)
A/J MGP_AJ_G0024479
protein coding gene Chr18:63164651-63178824 (+)
AKR/J MGP_AKRJ_G0024449
protein coding gene Chr18:64951870-64965516 (+)
BALB/cJ MGP_BALBcJ_G0024478
protein coding gene Chr18:63306094-63321305 (+)
C3H/HeJ MGP_C3HHeJ_G0024246
protein coding gene Chr18:65156897-65172449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024925
protein coding gene Chr18:67790026-67803707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022356
protein coding gene Chr18:62611333-62625409 (+)
CAST/EiJ MGP_CASTEiJ_G0023719
protein coding gene Chr18:65159052-65174247 (+)
CBA/J MGP_CBAJ_G0024216
protein coding gene Chr18:70042008-70056084 (+)
DBA/2J MGP_DBA2J_G0024346
protein coding gene Chr18:62833222-62847138 (+)
FVB/NJ MGP_FVBNJ_G0024312
protein coding gene Chr18:62215894-62229693 (+)
LP/J MGP_LPJ_G0024430
protein coding gene Chr18:65888774-65906222 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024341
protein coding gene Chr18:71430209-71444981 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024972
protein coding gene Chr18:65156123-65172222 (+)
PWK/PhJ MGP_PWKPhJ_G0023462
protein coding gene Chr18:63083871-63097836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023267
protein coding gene Chr18:65320377-65334005 (+)
WSB/EiJ MGP_WSBEiJ_G0023783
protein coding gene Chr18:65020213-65036595 (+)



Homology
more
  • Human Ortholog
    GRP, gastrin releasing peptide
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GRP, gastrin releasing peptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BN, GRP-10, preproGRP, proGRP
  • Links
    NCBI Gene ID: 2922
    neXtProt AC: NX_P07492
    UniProt: P07492

  • Chr Location
    18q21.32; chr18:59219188-59230774 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit attenuated scratching response to chloroquine, SLIGRL and BAM8-22.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024517 Ensembl Gene Model | MGI Sequence Detail 13760 C57BL/6J ±  kb
transcript ENSMUST00000173985 Ensembl | MGI Sequence Detail 952 Not Applicable  
polypeptide ENSMUSP00000133437 Ensembl | MGI Sequence Detail 146 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 9
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10273
References
more
  • Summaries
    All 56
    Developmental Gene Expression 17
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:15302 Spindel ER, et al., Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5699-703
  • Latest
    J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory