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Grn
Gene Detail
Symbol

Name
ID
Grn
granulin
MGI:95832
Synonyms
acrogranulin, epithelin, PC cell-derived growth factor, Pgrn, progranulin
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:102430315-102437048 bp, + strand
From VEGA annotation of GRCm38

  6734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRN
Gene Tree: Grn

Human
homologs
GRN, granulin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2896
neXtProt AC: NX_P28799

Human Synonyms: CLN11, GEP, GP88, PCDGF, PEPI, PGRN

Human Chr (Location): 17q21.32; chr17:44345086-44353106 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GRN

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Genomic Mutations involving Grn (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some knock-out alleles display enhanced macrophage functions. Mice homozygous for another knock-out allele display reproductive and behavioral abnormalities. Mice homozygous for a third null allele display premature death and increased cellular aging.
 
Interactions
Grn interacts with 85 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blastocyst hatching, chondrocyte proliferation, ...
Component cell surface, extracellular exosome, ...
Function cytokine activity, poly(A) RNA binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (189)    Tissues (107)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 71
RNA in situ 55
In situ reporter (knock in) 45
Western blot 12
RT-PCR 6
cDNA source data(484)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grn ; ZFIN grna    NEW 
Molecular
reagents
All nucleic(492) Genomic(2) cDNA(485) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000002816 (Evidence)
Ensembl Gene Model ENSMUSG00000034708 (Evidence)
Entrez Gene 14824 (Evidence)
UniGene 1568
DFCI TC1573727, TC1665822
DoTS DT.101406533, DT.40164845, DT.94306568, DT.94306571, DT.99866173
NIA Mouse Gene Index U013390
Consensus CDS Project CCDS48943.1
International Mouse Phenotyping Consortium Status Grn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002816 VEGA Gene Model | MGI Sequence Detail 6734 C57BL/6J ±  kb
transcript OTTMUST00000005699 VEGA | MGI Sequence Detail 2340 Not Applicable 
polypeptide OTTMUSP00000002716 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(126) RefSeq(2) UniProt(18)
Polymorphisms
RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006150 Cysteine-rich repeat
InterPro IPR000118 Granulin
Protein Ontology PR:000008271 granulins
References
(Earliest) J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
(Latest) J:217897 Hafler BP, et al., Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Brain Res. 2014 Nov 7;1588:168-74
All references(74)
Other
accession IDs
MGD-MRK-10272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory