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Grn
Gene Detail
 Symbol
Name
ID
Grn
granulin
MGI:95832
Synonyms acrogranulin, epithelin, PC cell-derived growth factor, Pgrn, progranulin
Feature Type protein coding gene
Genetic Map
Chromosome 11
66.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:102430315-102437048 bp, + strand
From VEGA annotation of GRCm38

  6734 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

Gene Tree: Grn

Human
homologs
Human Homolog GRN, granulin
NCBI Gene ID 2896
neXtProt AC  NX_P28799
Human Synonyms  CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Human Chr (Location)  17q21.32; chr17:44345123-44353106 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GRN
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some knock-out alleles display enhanced macrophage functions. Mice homozygous for another knock-out allele display reproductive and behavioral abnormalities. Mice homozygous for a third null allele display premature death and increased cellular aging.
 
Interactions
Grn interacts with 85 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blastocyst hatching, chondrocyte proliferation, ...
Component cell surface, extracellular region, ...
Function cytokine activity, poly(A) RNA binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (68)    Tissues (59)    Images (21)
Theiler Stages: 1, 2, 3, 5, 11, 13, 15, 19, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 55
RT-PCR 6
cDNA source data(484)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(492) Genomic(2) cDNA(485) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000002816 (Evidence)
Ensembl Gene ModelENSMUSG00000034708 (Evidence)
Entrez Gene14824 (Evidence)
UniGene1568
DFCITC1573727, TC1665822
DoTSDT.101406533, DT.40164845, DT.94306568, DT.94306571, DT.99866173
NIA Mouse Gene IndexU013390
Consensus CDS ProjectCCDS48943.1
International Mouse Knockout Project StatusGrn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002816 VEGA Gene Model | MGI Sequence Detail 6734 C57BL/6J ±  kb
transcript OTTMUST00000005699 VEGA | MGI Sequence Detail 2340 Not Applicable 
polypeptide OTTMUSP00000002716 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(2) UniProt(18)
Polymorphisms RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006150 Cysteine-rich repeat
InterPro IPR000118 Granulin
Protein Ontology PR:000008271 granulins
References (Earliest) J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
(Latest) J:211954 Hu Y, et al., Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4(+) Foxp3(+) regulatory T cells. Immunology. 2014 Jun;142(2):193-201
All references(75)
Other
accession IDs
MGD-MRK-10272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory