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Grn Gene Detail
Summary
  • Symbol
    Grn
  • Name
    granulin
  • Synonyms
    acrogranulin, epithelin, PC cell-derived growth factor, Pgrn, progranulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95832
    NCBI Gene: 14824
Location & Maps
more
  • Sequence Map
    Chr11:102430315-102437048 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6734 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GRN, granulin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GRN, granulin
    Orthology source: HomoloGene
  • Synonyms
    CLN11, GEP, GP88, PCDGF, PEPI, PGRN
  • Links
    NCBI Gene ID: 2896
    neXtProt AC: NX_P28799

  • Chr Location
    17q21.32; chr17:44345086-44353106 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1577
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GRN
  • Gene Tree
    Grn
Human Diseases
more
  • Diseases
    1 with Grn mouse models; 2 with human GRN associations

Human Disease Mouse Models
       Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related   OMIM: 607485 View 1 model
       Ceroid Lipofuscinosis, Neuronal, 11; CLN11   OMIM: 614706
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    11
  • Genomic Mutations
    1 involving Grn
  • Incidental Mutations
Mice homozygous for some knock-out alleles display enhanced macrophage functions. Mice homozygous for another knock-out allele display reproductive and behavioral abnormalities. Mice homozygous for a third null allele display premature death and increased cellular aging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002816 VEGA Gene Model | MGI Sequence Detail 6734 C57BL/6J ±  kb
transcript OTTMUST00000005699 VEGA | MGI Sequence Detail 2340 Not Applicable  
polypeptide OTTMUSP00000002716 VEGA | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 492
    Genomic 2
    cDNA 485
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10272
References
more
  • Summaries
    All 72
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
  • Latest
    J:225148 Wei F, et al., Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions. PLoS One. 2014;9(11):e112110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory