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Grik3
Gene Detail
 Symbol
Name
ID
Grik3
glutamate receptor, ionotropic, kainate 3
MGI:95816
Synonyms Glur7, Glur-7
Feature Type protein coding gene
Genetic Map
Chromosome 4
58.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:125490700-125714173 bp, + strand
From VEGA annotation of GRCm38

  223474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grik3

Human
homologs
Human Homolog GRIK3, glutamate receptor, ionotropic, kainate 3
NCBI Gene ID 2899
neXtProt AC  NX_Q13003
Human Synonyms  EAA5, GLR7, GluK3, GLUR7, GluR7a
Human Chr (Location)  1p34.3; chr1:36795527-37034243 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Gene trapped(85) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation.
 
Interactions
Grik3 interacts with 428 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, glutamate receptor signaling pathway, ...
Component axon, cell junction, ...
Function adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (14)    Tissues (13)    Images (5)
Theiler Stages: 11, 13, 14, 26
Assay TypeResults
RNA in situ 14
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009249 (Evidence)
Ensembl Gene ModelENSMUSG00000001985 (Evidence)
Entrez Gene14807 (Evidence)
UniGene40896
DFCITC1602258, TC1604157, TC1704358, TC1709980, TC1710668
DoTSDT.101269111, DT.101734341, DT.91382494, DT.91592487, DT.97381886, DT.97384948
NIA Mouse Gene IndexU087135, U089133, U136507, U253643, U332647
Consensus CDS ProjectCCDS38878.1
International Mouse Knockout Project StatusGrik3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009249 VEGA Gene Model | MGI Sequence Detail 223474 C57BL/6J ±  kb
transcript OTTMUST00000020938 VEGA | MGI Sequence Detail 8973 Not Applicable 
polypeptide OTTMUSP00000009596 VEGA | MGI Sequence Detail 919 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(3275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008242 glutamate receptor ionotropic, kainate 3
References (Earliest) J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
(Latest) J:193538 Cui S, et al., Developmental expression patterns of kainate receptors in the mouse spinal cord. Neuroreport. 2012 Dec 5;23(17):1012-6
All references(56)
Other
accession IDs
MGD-MRK-10146, MGD-MRK-10153, MGD-MRK-10254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory