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Grik3 Gene Detail
Summary
  • Symbol
    Grik3
  • Name
    glutamate receptor, ionotropic, kainate 3
  • Synonyms
    Glur7, Glur-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95816
    NCBI Gene: 14807
  • Gene Overview
    MyGene.info: GRIK3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125490700-125714173 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 58.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3255 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95816
protein coding gene Chr4:125490206-125714173 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028766
protein coding gene Chr4:127097131-127323691 (+)
A/J MGP_AJ_G0028725
protein coding gene Chr4:122099176-122321340 (+)
AKR/J MGP_AKRJ_G0028678
protein coding gene Chr4:125452841-125682956 (+)
BALB/cJ MGP_BALBcJ_G0028748
protein coding gene Chr4:122690793-122909237 (+)
C3H/HeJ MGP_C3HHeJ_G0028462
protein coding gene Chr4:125523414-125747162 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029190
protein coding gene Chr4:131978708-132218524 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026463
protein coding gene Chr4:115263796-115483331 (+)
CAST/EiJ MGP_CASTEiJ_G0027895
protein coding gene Chr4:123616678-123846928 (+)
CBA/J MGP_CBAJ_G0028428
protein coding gene Chr4:135237955-135462346 (+)
DBA/2J MGP_DBA2J_G0028577
protein coding gene Chr4:122572365-122793243 (+)
FVB/NJ MGP_FVBNJ_G0028544
protein coding gene Chr4:121207820-121429220 (+)
LP/J MGP_LPJ_G0028678
protein coding gene Chr4:127385510-127613993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028570
protein coding gene Chr4:140223648-140447079 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029228
protein coding gene Chr4:125803226-126033814 (+)
PWK/PhJ MGP_PWKPhJ_G0027616
protein coding gene Chr4:119015165-119238946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027442
protein coding gene Chr4:121600930-121831258 (+)
WSB/EiJ MGP_WSBEiJ_G0027975
protein coding gene Chr4:125897726-126126272 (+)



Homology
more
  • Human Ortholog
    GRIK3, glutamate ionotropic receptor kainate type subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK3, glutamate ionotropic receptor kainate type subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAA5, GLR7, GluK3, GLUR7, GluR7a
  • Links
    NCBI Gene ID: 2899
    neXtProt AC: NX_Q13003
    UniProt: Q13003

  • Chr Location
    1p34.3; chr1:36795527-37034243 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 73901
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GRIK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001985 Ensembl Gene Model | MGI Sequence Detail 223474 C57BL/6J ±  kb
    transcript ENSMUST00000030676 Ensembl | MGI Sequence Detail 8973 Not Applicable  
    polypeptide ENSMUSP00000030676 Ensembl | MGI Sequence Detail 919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008242 glutamate receptor ionotropic, kainate 3
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10146, MGD-MRK-10153, MGD-MRK-10254
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
    • Latest
      J:272647 Vernon CG, et al., N-glycan content modulates kainate receptor functional properties. J Physiol. 2017 Sep 1;595(17):5913-5930

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory