About   Help   FAQ
Grik3
Gene Detail
Symbol

Name
ID
Grik3
glutamate receptor, ionotropic, kainate 3
MGI:95816
Synonyms
Glur7, Glur-7
Feature Type
protein coding gene
Genetic Map
Chromosome 4
58.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:125490700-125714173 bp, + strand
From VEGA annotation of GRCm38

  223474 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRIK3
Gene Tree: Grik3

Human
homologs
GRIK3, glutamate receptor, ionotropic, kainate 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2899
neXtProt AC: NX_Q13003

Human Synonyms: EAA5, GLR7, GluK3, GLUR7, GluR7a

Human Chr (Location): 1p34.3; chr1:36795527-37034548 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(89) : Gene trapped(85) Targeted(4)
Genomic Mutations involving Grik3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation.
 
Interactions
Grik3 interacts with 427 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (14)    Tissues (13)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009249 (Evidence)
Ensembl Gene Model ENSMUSG00000001985 (Evidence)
Entrez Gene 14807 (Evidence)
UniGene 40896
DFCI TC1602258, TC1604157, TC1704358, TC1709980, TC1710668
DoTS DT.101269111, DT.101734341, DT.91382494, DT.91592487, DT.97381886, DT.97384948
NIA Mouse Gene Index U087135, U089133, U136507, U253643, U332647
Consensus CDS Project CCDS38878.1
International Mouse Phenotyping Consortium Status Grik3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009249 VEGA Gene Model | MGI Sequence Detail 223474 C57BL/6J ±  kb
transcript OTTMUST00000020938 VEGA | MGI Sequence Detail 8973 Not Applicable 
polypeptide OTTMUSP00000009596 VEGA | MGI Sequence Detail 919 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(3275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
InterPro IPR001508 Ionotropic glutamate receptor, metazoa
InterPro IPR028082 Periplasmic binding protein-like I
InterPro IPR001828 Receptor, ligand binding region
Protein Ontology PR:000008242 glutamate receptor ionotropic, kainate 3
References
(Earliest) J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
(Latest) J:193538 Cui S, et al., Developmental expression patterns of kainate receptors in the mouse spinal cord. Neuroreport. 2012 Dec 5;23(17):1012-6
All references(54)
Other
accession IDs
MGD-MRK-10146, MGD-MRK-10153, MGD-MRK-10254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory