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Grk4 Gene Detail
Summary
  • Symbol
    Grk4
  • Name
    G protein-coupled receptor kinase 4
  • Synonyms
    A830025H08Rik, Gprk2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:95801
    NCBI Gene: 14772
  • Gene Overview
    MyGene.info: GRK4
Location & Maps
more
  • Sequence Map
    Chr5:34660379-34755305 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94927 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.91 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GRK4, G protein-coupled receptor kinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRK4, G protein-coupled receptor kinase 4
    Orthology source: HomoloGene
  • Synonyms
    GPRK2L, GPRK4, GRK4a, IT11
  • Links
    NCBI Gene ID: 2868
    neXtProt AC: NX_P32298

  • Chr Location
    4p16.3; chr4:2963505-3040752 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    27 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    6
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    10 involving Grk4
  • Incidental Mutations
Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023169 VEGA Gene Model | MGI Sequence Detail 94927 C57BL/6J ±  kb
transcript OTTMUST00000056031 VEGA | MGI Sequence Detail 2408 Not Applicable  
polypeptide OTTMUSP00000026886 VEGA | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    232 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10235, MGI:1924341
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:19185 Grosson CL, et al., Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5. Mamm Genome. 1994 Jul;5(7):424-8
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory