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Grk4
Gene Detail
Symbol

Name
ID
Grk4
G protein-coupled receptor kinase 4
MGI:95801
Synonyms
A830025H08Rik, Gprk2l
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:34660379-34755305 bp, + strand
From VEGA annotation of GRCm38

  94927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRK4
Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk4

Human
homologs
GRK4, G protein-coupled receptor kinase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2868
neXtProt AC: NX_P32298

Human Synonyms: GPRK2L, GPRK4, GRK4a, IT11

Human Chr (Location): 4p16.3; chr4:2963505-3040752 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(6) Targeted(2)
Genomic Mutations involving Grk4 (7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.
 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Grk4 interacts with 243 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (36)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 26
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grk4    NEW 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023169 (Evidence)
Ensembl Gene Model ENSMUSG00000052783 (Evidence)
Entrez Gene 14772 (Evidence)
UniGene 117076
DFCI TC1589892, TC1608616, TC1685270
DoTS DT.101707277, DT.55200571, DT.94167663
NIA Mouse Gene Index U005491
EC 2.7.11.16
Consensus CDS Project CCDS19219.1, CCDS39070.1
International Mouse Phenotyping Consortium Status Grk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023169 VEGA Gene Model | MGI Sequence Detail 94927 C57BL/6J ±  kb
transcript OTTMUST00000056031 VEGA | MGI Sequence Detail 2408 Not Applicable 
polypeptide OTTMUSP00000026886 VEGA | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(16) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016137 RGS domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008258 G protein-coupled receptor kinase 4
References
(Earliest) J:19185 Grosson CL, et al., Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5. Mamm Genome. 1994 Jul;5(7):424-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-10235, MGI:1924341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory