Grk4
Gene Detail

Symbol Name ID

Grk4 G protein-coupled receptor kinase 4 MGI:95801

Synonyms

A830025H08Rik, Gprk2l

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:34660379-34755305 bp, + strand From VEGA annotation of GRCm38   94927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk4

Human homologs

Human Homolog		GRK4, G protein-coupled receptor kinase 4
NCBI Gene ID		2868
neXtProt AC		NX_P32298
Human Synonyms		GPRK2L, GPRK4, GRK4a, IT11
Human Chr (Location)		4p16.3; chr4:2965343-3042474 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	desensitization of G-protein coupled receptor protein signaling pathway, G-protein coupled receptor internalization, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, G-protein coupled receptor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (36)    Images (4)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	24
Northern blot	26

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023169 (Evidence)
Ensembl Gene Model	ENSMUSG00000052783 (Evidence)
Entrez Gene	14772 (Evidence)
UniGene	117076
DFCI	TC1589892, TC1608616, TC1685270
DoTS	DT.101707277, DT.55200571, DT.94167663
NIA Mouse Gene Index	U005491
EC	2.7.11.16
Consensus CDS Project	CCDS19219.1, CCDS39070.1
International Mouse Knockout Project Status	Grk4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023169	VEGA Gene Model | MGI Sequence Detail	94927	C57BL/6J
transcript	OTTMUST00000056031	VEGA | MGI Sequence Detail	2408	Not Applicable
polypeptide	OTTMUSP00000026886	VEGA | MGI Sequence Detail	574	Not Applicable

All sequences(41) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000239	GPCR kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008258	G-protein coupled receptor kinase 4

References

(Earliest) J:19185 Grosson CL, et al., Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5. Mamm Genome. 1994 Jul;5(7):424-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGD-MRK-10235, MGI:1924341