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Grk4
Gene Detail
 Symbol
Name
ID
Grk4
G protein-coupled receptor kinase 4
MGI:95801
Synonyms A830025H08Rik, Gprk2l
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:34660379-34755305 bp, + strand
From VEGA annotation of GRCm38

  94927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23158  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk4

Human
homologs
Human Homolog GRK4, G protein-coupled receptor kinase 4
NCBI Gene ID 2868
neXtProt AC  NX_P32298
Human Synonyms  GPRK2L, GPRK4, GRK4a, IT11
Human Chr (Location)  4p16.3; chr4:2963505-3040747 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(2)
 
Mice heterozygous for a knock-out allele are viable, fertile and overtly normal.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process desensitization of G-protein coupled receptor protein signaling pathway, G-protein coupled receptor internalization, ...
Component cytoplasm, cytosol, ...
Function ATP binding, G-protein coupled receptor kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (50)    Tissues (36)    Images (4)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 24
Northern blot 26
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023169 (Evidence)
Ensembl Gene ModelENSMUSG00000052783 (Evidence)
Entrez Gene14772 (Evidence)
UniGene117076
DFCITC1589892, TC1608616, TC1685270
DoTSDT.101707277, DT.55200571, DT.94167663
NIA Mouse Gene IndexU005491
EC2.7.11.16
Consensus CDS ProjectCCDS19219.1, CCDS39070.1
International Mouse Knockout Project StatusGrk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023169 VEGA Gene Model | MGI Sequence Detail 94927 C57BL/6J ±  kb
transcript OTTMUST00000056031 VEGA | MGI Sequence Detail 2408 Not Applicable 
polypeptide OTTMUSP00000026886 VEGA | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(16) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008258 G-protein coupled receptor kinase 4
References (Earliest) J:19185 Grosson CL, et al., Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5. Mamm Genome. 1994 Jul;5(7):424-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-10235, MGI:1924341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory