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Gpi1
Gene Detail
Symbol

Name
ID
Gpi1
glucose phosphate isomerase 1
MGI:95797
Synonyms
AMF, autocrine motility factor, Gpi-1, Gpi-1r, Gpi1-r, Gpi-1s, Gpi1-s, Gpi-1t, Gpi1-t, maturation factor, MF, neuroleukin, NK, NK/GPI, Org
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(178)
Sequence Map
Chr7:34202122-34230289 bp, - strand
From VEGA annotation of GRCm38

  28168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GPI
Protein SuperFamily: glucose-6-phosphate isomerase
Gene Tree: Gpi1

Human
homologs
GPI, glucose-6-phosphate isomerase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2821
neXtProt AC: NX_P06744

Human Synonyms: AMF, GNPI, NLK, PGI, PHI, SA36, SA-36

Human Chr (Location): 19q13.1; chr19:34359592-34402413 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GPI

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically and radiation induced(1) Chemically induced (ENU)(8) Chemically induced (other)(1) Gene trapped(8) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null mutations fail to develop beyond the egg cylinder stage and die by embryonic day 9.5. Homozygotes for a hypomorphic mutation exhibit nonspherocytic hemolytic anemia with hepatosplenomegaly.
 
Human Diseases Modeled in Mice Using Gpi1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Gpi1 interacts with 76 markers (Mir30a, Mir30b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process aldehyde catabolic process, angiogenesis, ...
Component ciliary membrane, cytoplasm, ...
Function cytokine activity, glucose-6-phosphate isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (179)    Tissues (148)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 179
cDNA source data(476)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN gpia, gpib    NEW 
Molecular
reagents
All nucleic(480) cDNA(477) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000008382 (Evidence)
Ensembl Gene Model ENSMUSG00000036427 (Evidence)
Entrez Gene 14751 (Evidence)
UniGene 589
DFCI TC1573838, TC1587062, TC1602473
DoTS DT.101320425, DT.101358666, DT.101712464, DT.102553283, DT.102553284, DT.110980142, DT.495008
NIA Mouse Gene Index U028425, U052539
EC 5.3.1.9
PDB 1U0E, 1U0F, 1U0G, 2CVP, 2CXN, 2CXO, 2CXP, 2CXQ, 2CXR, 2CXS, 2CXT, 2CXU
Consensus CDS Project CCDS21138.1
International Mouse Phenotyping Consortium Status Gpi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008382 VEGA Gene Model | MGI Sequence Detail 28168 C57BL/6J ±  kb
transcript OTTMUST00000019029 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000008735 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018189 Phosphoglucose isomerase, conserved site
InterPro IPR023096 Phosphoglucose isomerase, C-terminal
InterPro IPR001672 Phosphoglucose isomerase (PGI)
Protein Ontology PR:000008175 glucose-6-phosphate isomerase
References
(Earliest) J:5134 Hutton JJ, Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem Genet. 1969 Oct;3(5):507-15
(Latest) J:190355 Walker JA, et al., Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1(c) : A model for hereditary haemolytic anaemia. Eur J Immunol. 2012 Dec;42(12):3212-22
All references(225)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10227, MGD-MRK-10228, MGD-MRK-10229, MGD-MRK-10230, MGD-MRK-10231, MGD-MRK-10232, MGD-MRK-10233, MGD-MRK-10234, MGD-MRK-13047, MGI:95798, MGI:95799, MGI:95800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory