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Gpi1
Gene Detail
 Symbol
Name
ID
Gpi1
glucose phosphate isomerase 1
MGI:95797
Synonyms AMF, autocrine motility factor, Gpi-1, Gpi-1r, Gpi1-r, Gpi-1s, Gpi1-s, Gpi-1t, Gpi1-t, maturation factor, MF, neuroleukin, NK, NK/GPI, Org
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(178)
Sequence Map
Chr7:34202122-34230289 bp, - strand
From VEGA annotation of GRCm38

  28168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: glucose-6-phosphate isomerase
Gene Tree: Gpi1

Human
homologs
Human Homolog GPI, glucose-6-phosphate isomerase
NCBI Gene ID 2821
neXtProt AC  NX_P06744
Human Synonyms  AMF, GNPI, NLK, PGI, PHI, SA36, SA-36
Human Chr (Location)  19q13.1; chr19:34364740-34402413 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GPI
Alleles
and
phenotypes
All alleles(26) : Targeted(3) Gene trapped(8) Spontaneous(1) Chemically induced(10) Radiation induced(1) Other(4)
 
Homozygotes for null mutations fail to develop beyond the egg cylinder stage and die by embryonic day 9.5. Homozygotes for a hypomorphic mutation exhibit nonspherocytic hemolytic anemia with hepatosplenomegaly.
 
Human Diseases Modeled Using Mouse Gpi1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process aldehyde catabolic process, angiogenesis, ...
Component ciliary membrane, cytoplasm, ...
Function cytokine activity, glucose-6-phosphate isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (179)    Tissues (148)    Images (21)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 179
cDNA source data(476)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(480) cDNA(477) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008382 (Evidence)
Ensembl Gene ModelENSMUSG00000036427 (Evidence)
Entrez Gene14751 (Evidence)
UniGene589
DFCITC1573838, TC1587062, TC1602473
DoTSDT.101320425, DT.101358666, DT.101712464, DT.102553283, DT.102553284, DT.110980142, DT.495008
NIA Mouse Gene IndexU028425, U052539
EC5.3.1.9
PDB1U0E, 1U0F, 1U0G, 2CVP, 2CXN, 2CXO, 2CXP, 2CXQ, 2CXR, 2CXS, 2CXT, 2CXU
Consensus CDS ProjectCCDS21138.1
International Mouse Knockout Project StatusGpi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008382 VEGA Gene Model | MGI Sequence Detail 28168 C57BL/6J ±  kb
transcript OTTMUST00000019029 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000008735 VEGA | MGI Sequence Detail 558 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018189 Phosphoglucose isomerase, conserved site
InterPro IPR023096 Phosphoglucose isomerase, C-terminal
InterPro IPR001672 Phosphoglucose isomerase (PGI)
Protein Ontology PR:000008175 glucose-6-phosphate isomerase
References (Earliest) J:5134 Hutton JJ, Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem Genet. 1969 Oct;3(5):507-15
(Latest) J:190355 Walker JA, et al., Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1(c) : A model for hereditary haemolytic anaemia. Eur J Immunol. 2012 Dec;42(12):3212-22
All references(234)
Other
accession IDs
MGD-MRK-10227, MGD-MRK-10228, MGD-MRK-10229, MGD-MRK-10230, MGD-MRK-10231, MGD-MRK-10232, MGD-MRK-10233, MGD-MRK-10234, MGD-MRK-13047, MGI:95798, MGI:95799, MGI:95800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory