Gpi1
Gene Detail

Symbol Name ID

Gpi1 glucose phosphate isomerase 1 MGI:95797

Synonyms

AMF, autocrine motility factor, Gpi-1, Gpi-1r, Gpi1-r, Gpi-1s, Gpi1-s, Gpi-1t, Gpi1-t, maturation factor, MF, neuroleukin, NK, NK/GPI, Org

Feature Type

protein coding gene

Genetic Map

Chromosome 7

19.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(178)

Sequence Map

Chr7:34202122-34230289 bp, - strand From VEGA annotation of GRCm38   28168 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: glucose-6-phosphate isomerase
Gene Tree: Gpi1

Human homologs

Human Homolog		GPI, glucose-6-phosphate isomerase
NCBI Gene ID		2821
neXtProt AC		NX_P06744
Human Synonyms		AMF, GNPI, NLK, PGI, PHI, SA36, SA-36
Human Chr (Location)		19q13.1; chr19:34855645-34893318 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPI

Alleles and phenotypes

All alleles(26) : Targeted(3) Gene trapped(8) Spontaneous(1) Chemically induced(10) Radiation induced(1) Other(4)
 

Homozygotes for null mutations fail to develop beyond the egg cylinder stage and die by embryonic day 9.5. Homozygotes for a hypomorphic mutation exhibit nonspherocytic hemolytic anemia with hepatosplenomegaly.

 
Human Diseases Modeled Using Mouse Gpi1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	aldehyde catabolic process, angiogenesis, ...
Component	cilium membrane, cytoplasm, ...
Function	cytokine activity, glucose-6-phosphate isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (132)    Tissues (101)    Images (19)
Theiler Stages: 22

Assay Type	Results
RNA in situ	132

cDNA source data(476)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(480) cDNA(477) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008382 (Evidence)
Ensembl Gene Model	ENSMUSG00000036427 (Evidence)
Entrez Gene	14751 (Evidence)
UniGene	589
DFCI	TC1573838, TC1587062, TC1602473
DoTS	DT.101320425, DT.101358666, DT.101712464, DT.102553283, DT.102553284, DT.110980142, DT.495008
NIA Mouse Gene Index	U028425, U052539
EC	5.3.1.9
PDB	1U0E, 1U0F, 1U0G, 2CVP, 2CXN, 2CXO, 2CXP, 2CXQ, 2CXR, 2CXS, 2CXT, 2CXU
Consensus CDS Project	CCDS21138.1
International Mouse Knockout Project Status	Gpi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008382	VEGA Gene Model | MGI Sequence Detail	28168	C57BL/6J
transcript	OTTMUST00000019029	VEGA | MGI Sequence Detail	2037	Not Applicable
polypeptide	OTTMUSP00000008735	VEGA | MGI Sequence Detail	558	Not Applicable

All sequences(62) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(196 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018189	Phosphoglucose isomerase, conserved site
InterPro	IPR023096	Phosphoglucose isomerase, C-terminal
InterPro	IPR001672	Phosphoglucose isomerase (PGI)
Protein Ontology	PR:000008175	glucose-6-phosphate isomerase

References

(Earliest) J:5134 Hutton JJ, Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem Genet. 1969 Oct;3(5):507-15
(Latest) J:190355 Walker JA, et al., Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1(c) : A model for hereditary haemolytic anaemia. Eur J Immunol. 2012 Dec;42(12):3212-22
All references(231)

Other accession IDs

MGD-MRK-10227, MGD-MRK-10228, MGD-MRK-10229, MGD-MRK-10230, MGD-MRK-10231, MGD-MRK-10232, MGD-MRK-10233, MGD-MRK-10234, MGD-MRK-13047, MGI:95798, MGI:95799, MGI:95800