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Got1 Gene Detail
Summary
  • Symbol
    Got1
  • Name
    glutamic-oxaloacetic transaminase 1, soluble
  • Synonyms
    cAspAT, cytosolic aspartate aminotransferase, Got-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95791
    NCBI Gene: 14718
  • Gene Overview
    MyGene.info: GOT1
Location & Maps
more
  • Sequence Map
    Chr19:43499752-43524605 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24854 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    GOT1, glutamic-oxaloacetic transaminase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GOT1, glutamic-oxaloacetic transaminase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AST1, ASTQTL1, cAspAT, cCAT, GIG18
  • Links
    NCBI Gene ID: 2805
    neXtProt AC: NX_P17174

  • Chr Location
    10q24.1-q25.1; chr10:99396870-99430773 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    56
  • Gene trapped
    54
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023608 VEGA Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
transcript OTTMUST00000057631 VEGA | MGI Sequence Detail 2058 Not Applicable  
polypeptide OTTMUSP00000027809 VEGA | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008153 aspartate aminotransferase, cytoplasmic
  • EC
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
    IPR000796 Aspartate/other aminotransferase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
Molecular
Reagents
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  • All nucleic 235
    Genomic 5
    cDNA 229
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10213, MGD-MRK-10215, MGI:2147593
References
more
  • Summaries
    All 55
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 8
  • Earliest
    J:5163 DeLorenzo RJ, et al., Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci. Biochem Genet. 1970 Apr;4(2):259-73
  • Latest
    J:218171 Falix FA, et al., Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol. 2014 Dec 15;396(2):201-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory