Gnrhr
Gene Detail

Symbol Name ID

Gnrhr gonadotropin releasing hormone receptor MGI:95790

Feature Type

protein coding gene

Genetic Map

Chromosome 5

43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:86180754-86197901 bp, - strand From VEGA annotation of GRCm38   17148 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: gonadotropin-releasing hormone receptor
Gene Tree: Gnrhr

Human homologs

Human Homolog		GNRHR, gonadotropin-releasing hormone receptor
NCBI Gene ID		2798
neXtProt AC		NX_P30968
Human Synonyms		GNRHR1, GRHR, HH7, LHRHR, LRHR
Human Chr (Location)		4q21.2; chr4:68603093-68621804 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GNRHR

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Chemically induced(1)
 

Homozygous mutant mice display prepubescent internal reproductive tracts with hypogonadism and hypogonadotrophy.

 
Human Diseases Modeled Using Mouse Gnrhr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cellular response to gonadotropin-releasing hormone, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	gonadotropin-releasing hormone receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	1

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(16) cDNA(15) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000025622 (Evidence)
Ensembl Gene Model	ENSMUSG00000029255 (Evidence)
Entrez Gene	14715 (Evidence)
UniGene	26791
DFCI	TC1589688, TC1595829, TC1675689
DoTS	DT.101363447, DT.40167518, DT.50315068
NIA Mouse Gene Index	U026346
Consensus CDS Project	CCDS19379.1
International Mouse Knockout Project Status	Gnrhr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025622	VEGA Gene Model | MGI Sequence Detail	17148	C57BL/6J
transcript	OTTMUST00000063031	VEGA | MGI Sequence Detail	1211	Not Applicable
polypeptide	OTTMUSP00000031139	VEGA | MGI Sequence Detail	327	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001658	Gonadotrophin releasing hormone receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001588	gonadotropin-releasing hormone I receptor

References

(Earliest) J:1596 Tsutsumi M, et al., Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul;6(7):1163-9
(Latest) J:191830 Alim Z, et al., Gonadotrope plasticity at cellular and population levels. Endocrinology. 2012 Oct;153(10):4729-39
All references(65)

Other accession IDs

MGD-MRK-10209