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Gnrhr Gene Detail
Summary
  • Symbol
    Gnrhr
  • Name
    gonadotropin releasing hormone receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95790
    NCBI Gene: 14715
  • Gene Overview
    MyGene.info: GNRHR
Location & Maps
more
  • Sequence Map
    Chr5:86180754-86197901 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17148 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GNRHR, gonadotropin releasing hormone receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GNRHR, gonadotropin releasing hormone receptor
    Orthology source: HomoloGene
  • Synonyms
    GNRHR1, GRHR, HH7, LHRHR, LRHR
  • Links
    NCBI Gene ID: 2798
    neXtProt AC: NX_P30968

  • Chr Location
    4q21.2; chr4:67737375-67756086 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gnrhr mouse models; 1 with human GNRHR associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 7 with or without Anosmia; HH7   OMIM: 146110 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 6 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Gnrhr
  • Incidental Mutations
Homozygous mutant mice display prepubescent internal reproductive tracts with hypogonadism and hypogonadotrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025622 VEGA Gene Model | MGI Sequence Detail 17148 C57BL/6J ±  kb
transcript OTTMUST00000063031 VEGA | MGI Sequence Detail 1211 Not Applicable  
polypeptide OTTMUSP00000031139 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    232 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001588 gonadotropin-releasing hormone I receptor
  • InterPro Domains
    IPR001658 Gonadotrophin-releasing hormone receptor family
    IPR027982 Gonadotropin-releasing hormone receptor
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 34
    Genomic 16
    cDNA 14
    Primer pair 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10209
References
more
  • Summaries
    All 71
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:1596 Tsutsumi M, et al., Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul;6(7):1163-9
  • Latest
    J:216309 Roybal LL, et al., Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHbeta. Mol Endocrinol. 2014 Oct;28(10):1640-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory