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Gnrhr
Gene Detail
 Symbol
Name
ID
Gnrhr
gonadotropin releasing hormone receptor
MGI:95790
Feature Type protein coding gene
Genetic Map
Chromosome 5
43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:86180754-86197901 bp, - strand
From VEGA annotation of GRCm38

  17148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: gonadotropin-releasing hormone receptor
Gene Tree: Gnrhr

Human
homologs
Human Homolog GNRHR, gonadotropin-releasing hormone receptor
NCBI Gene ID 2798
neXtProt AC  NX_P30968
Human Synonyms  GNRHR1, GRHR, HH7, LHRHR, LRHR
Human Chr (Location)  4q21.2; chr4:67737375-67756086 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GNRHR
Alleles
and
phenotypes
All alleles(5) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display prepubescent internal reproductive tracts with hypogonadism and hypogonadotrophy.
 
Human Diseases Modeled Using Mouse Gnrhr (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of cell proliferation, ...
Component integral component of membrane, membrane, ...
Function gonadotropin-releasing hormone receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (13)    Tissues (9)    Images (3)
Theiler Stages: 19, 20, 22, 28
Assay TypeResults
RNA in situ 1
RT-PCR 12
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) Genomic(16) cDNA(14) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025622 (Evidence)
Ensembl Gene ModelENSMUSG00000029255 (Evidence)
Entrez Gene14715 (Evidence)
UniGene26791
DFCITC1589688, TC1595829, TC1675689
DoTSDT.101363447, DT.40167518, DT.50315068
NIA Mouse Gene IndexU026346
Consensus CDS ProjectCCDS19379.1
International Mouse Knockout Project StatusGnrhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025622 VEGA Gene Model | MGI Sequence Detail 17148 C57BL/6J ±  kb
transcript OTTMUST00000063031 VEGA | MGI Sequence Detail 1211 Not Applicable 
polypeptide OTTMUSP00000031139 VEGA | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(233 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001658 Gonadotrophin releasing hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001588 gonadotropin-releasing hormone I receptor
References (Earliest) J:1596 Tsutsumi M, et al., Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor. Mol Endocrinol. 1992 Jul;6(7):1163-9
(Latest) J:204036 Tran S, et al., Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol. 2013 Mar;27(3):407-21
All references(67)
Other
accession IDs
MGD-MRK-10209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory