About   Help   FAQ
Gnrh1 Gene Detail
Summary
  • Symbol
    Gnrh1
  • Name
    gonadotropin releasing hormone 1
  • Synonyms
    LHRH, LNRH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95789
    NCBI Gene: 14714
  • Gene Overview
    MyGene.info: GNRH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:67745181-67749439 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.66 cM
  • Mapping Data
    12 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GNRH, GRH, LHRH, LNRH
  • Links
    NCBI Gene ID: 2796
    neXtProt AC: NX_P01148
    UniProt: P01148

  • Chr Location
    8p21.2; chr8:25419258-25425040 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gnrh1 mouse models; 2 with human GNRH1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015812 Ensembl Gene Model | MGI Sequence Detail 4259 C57BL/6J ±  kb
    transcript ENSMUST00000111095 Ensembl | MGI Sequence Detail 486 Not Applicable  
    polypeptide ENSMUSP00000106724 Ensembl | MGI Sequence Detail 90 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      66 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 4
      cDNA 12
      Primer pair 5
      Other 10

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10208, MGD-MRK-10915
    References
    more
    • Summaries
      All 311
      Developmental Gene Expression 106
      Diseases 1
      Gene Ontology 9
      Phenotypes 99
    • Earliest
      J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
    • Latest
      J:261718 Phumsatitpong C, et al., Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice. Endocrinology. 2018 Jan 1;159(1):414-425

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory