Gnrh1
Gene Detail

Symbol Name ID

Gnrh1 gonadotropin releasing hormone 1 MGI:95789

STS

D14Nds6

Synonyms

LHRH, LNRH

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr14:67745229-67749435 bp, + strand From Ensembl annotation of GRCm38   4207 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: gonadoliberin
Gene Tree: Gnrh1

Human homologs

Human Homolog		GNRH1, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
NCBI Gene ID		2796
neXtProt AC		NX_P01148
Human Synonyms		GNRH, GRH, HH12, LHRH, LNRH
Human Chr (Location)		8p21-p11.2; chr8:25276774-25282556 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GNRH1

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(2) Spontaneous(1)
 

Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.

 
Human Diseases Modeled Using Mouse Gnrh1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	multicellular organismal development, negative regulation of apoptotic process, ...
Component	extracellular region, extracellular space
Function	gonadotropin hormone-releasing hormone activity, hormone activity

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (36)    Tissues (13)    Images (28)
Theiler Stages: 20, 21, 22, 23

Assay Type	Results
Immunohistochemistry	31
RNA in situ	5

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(4) cDNA(9) Primer pair(2) Other(3)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000015812 (Evidence)
Entrez Gene	14714 (Evidence)
UniGene	358309
DFCI	TC1649990
DoTS	DT.103545888
NIA Mouse Gene Index	U015799
Consensus CDS Project	CCDS27231.1
International Mouse Knockout Project Status	Gnrh1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000015812	Ensembl Gene Model | MGI Sequence Detail	4207	C57BL/6J
transcript	ENSMUST00000111095	Ensembl | MGI Sequence Detail	521	Not Applicable
polypeptide	ENSMUSP00000106724	Ensembl | MGI Sequence Detail	90	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

PCR(4) : SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019792	Gonadoliberin I
InterPro	IPR004079	Gonadoliberin I precursor
InterPro	IPR002012	Gonadotropin-releasing hormone
Protein Ontology	PR:000008127	progonadoliberin-1

References

(Earliest) J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
(Latest) J:192428 McCabe MJ, et al., Androgen initiates Sertoli cell tight junction formation in the hypogonadal (hpg) mouse. Biol Reprod. 2012 Aug;87(2):38
All references(228)

Other accession IDs

MGD-MRK-10208, MGD-MRK-10915