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Gnrh1
Gene Detail
Symbol

Name
ID
Gnrh1
gonadotropin releasing hormone 1
MGI:95789
STS
Synonyms
LHRH, LNRH
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr14:67745229-67749435 bp, + strand
From Ensembl annotation of GRCm38

  4207 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: gonadoliberin
Gene Tree: Gnrh1

Human
homologs
Human Homolog GNRH1, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
NCBI Gene ID 2796
neXtProt AC  NX_P01148
Human Synonyms  GNRH, GRH, HH12, LHRH, LNRH
Human Chr (Location)  8p21-p11.2; chr8:25419258-25425040 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human GNRH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Spontaneous(1) Targeted(3)
 
Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.
 
Human Diseases Modeled Using Mouse Gnrh1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Gnrh1 interacts with 15 markers (Mir7-1, Mir100, Mir203, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (81 records)
Data Summary: Results (75)    Tissues (42)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 50
RNA in situ 21
RT-PCR 4
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(4) cDNA(10) Primer pair(4) Other(6)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000015812 (Evidence)
Entrez Gene14714 (Evidence)
UniGene358309
DFCITC1649990
DoTSDT.103545888
NIA Mouse Gene IndexU015799
Consensus CDS ProjectCCDS27231.1
International Mouse Knockout Project StatusGnrh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015812 Ensembl Gene Model | MGI Sequence Detail 4207 C57BL/6J ±  kb
transcript ENSMUST00000111095 Ensembl | MGI Sequence Detail 521 Not Applicable 
polypeptide ENSMUSP00000106724 Ensembl | MGI Sequence Detail 90 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(5)
Polymorphisms
PCR(4) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019792 Gonadoliberin I
InterPro IPR004079 Gonadoliberin I precursor
InterPro IPR002012 Gonadotropin-releasing hormone
Protein Ontology PR:000008127 progonadoliberin-1
References
(Earliest) J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
(Latest) J:207602 Kumar D, et al., Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. J Neurosci. 2014 Mar 5;34(10):3756-66
All references(239)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10208, MGD-MRK-10915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory