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Gnrh1 Gene Detail
Summary
  • Symbol
    Gnrh1
  • Name
    gonadotropin releasing hormone 1
  • Synonyms
    LHRH, LNRH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95789
    NCBI Gene: 14714
  • Gene Overview
    MyGene.info: GNRH1
Location & Maps
more
  • Sequence Map
    Chr14:67745229-67749435 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4207 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GNRH1, gonadotropin releasing hormone 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GNRH, GRH, LHRH, LNRH
  • Links
    NCBI Gene ID: 2796
    neXtProt AC: NX_P01148

  • Chr Location
    8p21-p11.2; chr8:25419258-25425040 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gnrh1 mouse models; 1 with human GNRH1 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 12 with or without Anosmia; HH12   OMIM: 614841 View 1 model
       Hypogonadotropic Hypogonadism 7 with or without Anosmia; HH7   OMIM: 146110
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Gnrh1
Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015812 Ensembl Gene Model | MGI Sequence Detail 4207 C57BL/6J ±  kb
transcript ENSMUST00000111095 Ensembl | MGI Sequence Detail 521 Not Applicable  
polypeptide ENSMUSP00000106724 Ensembl | MGI Sequence Detail 90 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 4
    cDNA 10
    Primer pair 5
    Other 10

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10208, MGD-MRK-10915
References
more
  • Summaries
    All 245
    Developmental Gene Expression 90
    Diseases 1
    Gene Ontology 8
    Phenotypes 94
  • Earliest
    J:5877 Cattanach BM, et al., Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature. 1977 Sep 22;269(5626):338-40
  • Latest
    J:227057 Rattazzi L, et al., Impaired sense of smell and altered olfactory system in RAG-1(--) immunodeficient mice. Front Neurosci. 2015;9:318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory