Gng7
Gene Detail

Symbol Name ID

Gng7 guanine nucleotide binding protein (G protein), gamma 7 MGI:95787

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr10:80948624-81014945 bp, - strand From VEGA annotation of GRCm38   66322 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31293  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng7

Human homologs

Human Homolog		GNG7, guanine nucleotide binding protein (G protein), gamma 7
NCBI Gene ID		2788
neXtProt AC		NX_O60262
Human Chr (Location)		19p13.3; chr19:2511220-2702748 (-)  GRCh38

Alleles and phenotypes

All alleles(116) : Gene trapped(108) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit an enhanced startle response, loss of dopamine- and forskolin-stimulated adenylyl cyclase activity in the striatum, and increased mean insulin levels in males.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	behavioral fear response, G-protein coupled receptor signaling pathway, ...
Component	extracellular vesicular exosome, heterotrimeric G-protein complex, ...
Function	signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (113)    Tissues (41)    Images (52)
Theiler Stages: 1, 2, 3, 4, 19, 23, 28

Assay Type	Results
RNA in situ	103
RT-PCR	10

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000030294 (Evidence)
Ensembl Gene Model	ENSMUSG00000048240 (Evidence)
Entrez Gene	14708 (Evidence)
UniGene	222496
DFCI	TC1585194, TC1604854, TC1626539
DoTS	DT.101377940, DT.110603524, DT.40182368
NIA Mouse Gene Index	U032029
Consensus CDS Project	CCDS24039.1
International Mouse Knockout Project Status	Gng7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030294	VEGA Gene Model | MGI Sequence Detail	66322	C57BL/6J
transcript	OTTMUST00000074996	VEGA | MGI Sequence Detail	3382	Not Applicable
polypeptide	OTTMUSP00000039239	VEGA | MGI Sequence Detail	68	Not Applicable

All sequences(62) RefSeq(6) UniProt(5)

Polymorphisms

RFLP(1) : SNPs within 2kb(125 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR015898	G-protein gamma-like domain
InterPro	IPR001770	G-protein, gamma subunit
Protein Ontology	PR:000008111	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

References

(Earliest) J:22157 Cali JJ, et al., Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning. J Biol Chem. 1992 Nov 25;267(33):24023-7
(Latest) J:193905 Sasaki K, et al., Age-dependent dystonia in striatal Ggamma7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole. J Neurochem. 2013 Mar;124(6):844-54
All references(45)

Other accession IDs

MGD-MRK-10206, MGI:2143677