Gng7 MGI Mouse Gene Detail - MGI:95787 - guanine nucleotide binding protein (G protein), gamma 7

Symbol

Gng7
Name

guanine nucleotide binding protein (G protein), gamma 7

Feature Type

protein coding gene
IDs

MGI:95787
NCBI Gene: 14708
Gene Overview

MyGene.info: GNG7
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:80784458-80850779 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

SNPs within 2kb

120 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95787	protein coding gene	Chr10:80784458-80850794 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017530	protein coding gene	Chr10:81622257-81691261 (-)
A/J	MGP_AJ_G0017508	protein coding gene	Chr10:78742237-78809666 (-)
AKR/J	MGP_AKRJ_G0017469	protein coding gene	Chr10:80904550-80972776 (-)
BALB/cJ	MGP_BALBcJ_G0017470	protein coding gene	Chr10:78958053-79024644 (-)
C3H/HeJ	MGP_C3HHeJ_G0017293	protein coding gene	Chr10:80992096-81055253 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017924	protein coding gene	Chr10:84421065-84488471 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015613	protein coding gene	Chr10:74952055-75015035 (-)
CAST/EiJ	MGP_CASTEiJ_G0016860	protein coding gene	Chr10:81224645-81295021 (-)
CBA/J	MGP_CBAJ_G0017265	protein coding gene	Chr10:87695456-87793000 (-)
DBA/2J	MGP_DBA2J_G0017371	protein coding gene	Chr10:77942708-78004374 (-)
FVB/NJ	MGP_FVBNJ_G0017365	protein coding gene	Chr10:77174498-77242400 (-)
LP/J	MGP_LPJ_G0017442	protein coding gene	Chr10:82080584-82143696 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017391	protein coding gene	Chr10:89596058-89667294 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017965	protein coding gene	Chr10:80896994-80965708 (-)
PWK/PhJ	MGP_PWKPhJ_G0016641	protein coding gene	Chr10:77837229-77901697 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016431	protein coding gene	Chr10:79850856-79915408 (-)
WSB/EiJ	MGP_WSBEiJ_G0016920	protein coding gene	Chr10:80933133-81004065 (-)

Human Ortholog

GNG7, G protein subunit gamma 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNG7, G protein subunit gamma 7
Links

HGNC:4410

NCBI Gene ID: 2788

neXtProt AC: NX_O60262

UniProt: O60262
Chr Location

19p13.3; chr19:2511219-2702748 (-) GRCh38.p7

Alliance of Genome Resources

Gng7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNG7
Protein SuperFamily

GTP-binding regulatory protein gamma chain
Gene Tree

Gng7

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
1 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

103
Chemically induced (other)

1
Gene trapped

92
Targeted

10
Genomic Mutations

1 involving Gng7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Mice homozygous for a knock-out allele exhibit an enhanced startle response, loss of dopamine- and forskolin-stimulated adenylyl cyclase activity in the striatum, and increased mean insulin levels in males.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

38
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gng7

ZFIN gng7

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Gng7 interacts with 283 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

66
RefSeq

8
UniProt

5
CCDS

CCDS24039.1

Ensembl

ENSMUSG00000048240 (Evidence)
NCBI Gene

14708

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048240	Ensembl Gene Model \| MGI Sequence Detail	66322	C57BL/6J	± kb
transcript	ENSMUST00000099462	Ensembl \| MGI Sequence Detail	3425	Not Applicable
polypeptide	ENSMUSP00000097061	Ensembl \| MGI Sequence Detail	69	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008111 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

(term hierarchy)
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR001770 G-protein, gamma subunit

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 2

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MGD-MRK-10206, MGI:2143677

Summaries

All 49

Developmental Gene Expression 4

Diseases 1

Gene Ontology 3

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:291693 Halder SK, et al., Ggamma7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety. Biochem Biophys Res Commun. 2020 Jan 29;522(1):264-269

TSS for Gng7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98544	Chr10:80850736-80850771 (-)	25 bp
Tssr98543	Chr10:80850712-80850735 (-)	55 bp
Tssr98542	Chr10:80837172-80837204 (-)	13,591 bp
Tssr98541	Chr10:80837092-80837122 (-)	13,672 bp
Tssr98540	Chr10:80834008-80834026 (-)	16,762 bp
Tssr98539	Chr10:80833980-80833997 (-)	16,790 bp
Tssr98538	Chr10:80833955-80833966 (-)	16,818 bp
Tssr98537	Chr10:80793663-80793682 (-)	57,106 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/01/2021 MGI 6.17