Gng7 MGI Mouse Gene Detail - MGI:95787 - guanine nucleotide binding protein (G protein), gamma 7

Gng7 Gene Detail

Symbol

Gng7
Name

guanine nucleotide binding protein (G protein), gamma 7

Feature Type

protein coding gene
IDs

MGI:95787
NCBI Gene: 14708
Gene Overview

MyGene.info: GNG7

Sequence Map

Chr10:80948624-81014945 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

66322 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

Human Ortholog

GNG7, G protein subunit gamma 7

Vertebrate Orthologs

10

Human Ortholog

GNG7, G protein subunit gamma 7
Orthology source: HomoloGene, HGNC
Links

HGNC:4410

NCBI Gene ID: 2788

neXtProt AC: NX_O60262
Chr Location

19p13.3; chr19:2511220-2702748 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 31293
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: GNG7
Protein SuperFamily

GTP-binding regulatory protein gamma chain
Gene Tree

Gng7

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
1 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

119
Chemically induced (other)

1
Gene trapped

108
Targeted

10
Genomic Mutations

1 involving Gng7
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a knock-out allele exhibit an enhanced startle response, loss of dopamine- and forskolin-stimulated adenylyl cyclase activity in the striatum, and increased mean insulin levels in males.

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All GO Annotations

11
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

110
Tissues

38
cDNA Data

21
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase gng7

ZFIN gng7

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Gng7 interacts with 283 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

53
RefSeq

4
UniProt

5
CCDS

CCDS24039.1
UniGene

222496

			Length	Strain/Species	Flank
genomic	OTTMUSG00000030294	VEGA Gene Model \| MGI Sequence Detail	66322	C57BL/6J	± kb
transcript	OTTMUST00000075007	VEGA \| MGI Sequence Detail	875	Not Applicable
polypeptide	OTTMUSP00000039249	VEGA \| MGI Sequence Detail	68	Not Applicable

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SNPs within 2kb

125 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000008111 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR001770 G-protein, gamma subunit

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 2

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MGD-MRK-10206, MGI:2143677

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 20
Earliest

J:22157 Cali JJ, et al., Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning. J Biol Chem. 1992 Nov 25;267(33):24023-7
Latest

J:210178 Ikegami M, et al., Striatal dopamine D1 receptor is essential for contextual fear conditioning. Sci Rep. 2014;4:3976

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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