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Gnb3
Gene Detail
 Symbol
Name
ID
Gnb3
guanine nucleotide binding protein (G protein), beta 3
MGI:95785
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr6:124834240-124840275 bp, - strand
From VEGA annotation of GRCm38

  6036 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb3

Human
homologs
Human Homolog GNB3, guanine nucleotide binding protein (G protein), beta polypeptide 3
NCBI Gene ID 2784
neXtProt AC  NX_P16520
Human Chr (Location)  12p13; chr12:6840211-6847400 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNB3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal light ON response and synaptic maintenance.
 
Interactions
Gnb3 interacts with 71 markers (Mir22, Mir34a, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process G-protein coupled receptor signaling pathway, GTP catabolic process, ...
Component cell body, extracellular vesicular exosome, ...
Function GTPase activity, GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (57)    Tissues (28)    Images (26)
Theiler Stages: 4, 23, 24, 27, 28
Assay TypeResults
RNA in situ 39
RT-PCR 18
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(24) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000027058 (Evidence)
Ensembl Gene ModelENSMUSG00000023439 (Evidence)
Entrez Gene14695 (Evidence)
UniGene68889
DFCITC1584707, TC1589912
DoTSDT.55122875, DT.91336873
NIA Mouse Gene IndexU027852
Consensus CDS ProjectCCDS20532.1
International Mouse Knockout Project StatusGnb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027058 VEGA Gene Model | MGI Sequence Detail 6036 C57BL/6J ±  kb
transcript OTTMUST00000066896 VEGA | MGI Sequence Detail 1846 Not Applicable 
polypeptide OTTMUSP00000033588 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001632 G-protein, beta subunit
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR016346 Guanine nucleotide-binding protein, beta subunit
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008099 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
References (Earliest) J:10436 Danciger M, et al., The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8. Genomics. 1990 Mar;6(3):428-35
(Latest) J:209852 Prandi S, et al., A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820
All references(46)
Other
accession IDs
MGD-MRK-10198, MGD-MRK-10204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory