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Gnaz
Gene Detail
 Symbol
Name
ID
Gnaz
guanine nucleotide binding protein, alpha z subunit
MGI:95780
Synonyms Gz
Feature Type protein coding gene
Genetic Map
Chromosome 10
38.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:74967177-75016907 bp, + strand
From VEGA annotation of GRCm38

  49731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnaz

Human
homologs
Human Homolog GNAZ, guanine nucleotide binding protein (G protein), alpha z polypeptide
NCBI Gene ID 2781
neXtProt AC  NX_P19086
Human Chr (Location)  22q11.22; chr22:23070483-23125034 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances.
 
Interactions
Gnaz interacts with 186 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component cytosol, extracellular vesicular exosome, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (137)    Tissues (55)    Images (25)
Theiler Stages: 1, 2, 3, 4, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 69
Western blot 6
RT-PCR 62
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033002 (Evidence)
Ensembl Gene ModelENSMUSG00000040009 (Evidence)
Entrez Gene14687 (Evidence)
DFCITC1580730, TC1644779
DoTSDT.101293703, DT.110606640, DT.60102033
NIA Mouse Gene IndexU040734
Consensus CDS ProjectCCDS23922.1
International Mouse Knockout Project StatusGnaz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033002 VEGA Gene Model | MGI Sequence Detail 49731 C57BL/6J ±  kb
transcript OTTMUST00000082314 VEGA | MGI Sequence Detail 3519 Not Applicable 
polypeptide OTTMUSP00000044104 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008094 guanine nucleotide-binding protein G(z) subunit alpha
References (Earliest) J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
(Latest) J:202828 Regard JB, et al., Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013 Nov;19(11):1505-12
All references(55)
Other
accession IDs
MGD-MRK-10194, MGI:2143685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory