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Gnaz Gene Detail
Summary
  • Symbol
    Gnaz
  • Name
    guanine nucleotide binding protein, alpha z subunit
  • Synonyms
    Gz
  • Feature Type
    protein coding gene
  • IDs
    MGI:95780
    NCBI Gene: 14687
  • Gene Overview
    MyGene.info: GNAZ
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:74967177-75016907 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95780
protein coding gene Chr10:74967090-75016907 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017349
protein coding gene Chr10:75099286-75150247 (+)
A/J MGP_AJ_G0017326
protein coding gene Chr10:72525290-72576384 (+)
AKR/J MGP_AKRJ_G0017287
protein coding gene Chr10:74461636-74512756 (+)
BALB/cJ MGP_BALBcJ_G0017286
protein coding gene Chr10:72722581-72772994 (+)
C3H/HeJ MGP_C3HHeJ_G0017110
protein coding gene Chr10:74509412-74560508 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017744
protein coding gene Chr10:77767467-77820858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015434
protein coding gene Chr10:68994723-69044833 (+)
CAST/EiJ MGP_CASTEiJ_G0016680
protein coding gene Chr10:74816019-74867941 (+)
CBA/J MGP_CBAJ_G0017082
protein coding gene Chr10:80817166-80869261 (+)
DBA/2J MGP_DBA2J_G0017187
protein coding gene Chr10:71831537-71881954 (+)
FVB/NJ MGP_FVBNJ_G0017180
protein coding gene Chr10:70972754-71025243 (+)
LP/J MGP_LPJ_G0017260
protein coding gene Chr10:75589038-75641179 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017208
protein coding gene Chr10:82939493-82993307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017783
protein coding gene Chr10:74496173-74549079 (+)
PWK/PhJ MGP_PWKPhJ_G0016464
protein coding gene Chr10:71628956-71680214 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016247
protein coding gene Chr10:73747894-73797575 (+)
WSB/EiJ MGP_WSBEiJ_G0016744
protein coding gene Chr10:74460556-74513631 (+)



Homology
more
  • Human Ortholog
    GNAZ, G protein subunit alpha z
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNAZ, G protein subunit alpha z
    Orthology source: HomoloGene, HGNC
  • Synonyms
    gz-alpha
  • Links
    NCBI Gene ID: 2781
    neXtProt AC: NX_P19086
    UniProt: P19086

  • Chr Location
    22q11.22-q11.23; chr22:23070483-23125037 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22574
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNAZ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040009 Ensembl Gene Model | MGI Sequence Detail 49731 C57BL/6J ±  kb
    transcript ENSMUST00000037813 Ensembl | MGI Sequence Detail 3519 Not Applicable  
    polypeptide ENSMUSP00000036087 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008094 guanine nucleotide-binding protein G(z) subunit alpha
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10194, MGI:2143685
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:247696 Vancura P, et al., Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors. PLoS One. 2017;12(10):e0187411

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory