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Gnaz Gene Detail
Summary
  • Symbol
    Gnaz
  • Name
    guanine nucleotide binding protein, alpha z subunit
  • Synonyms
    Gz
  • Feature Type
    protein coding gene
  • IDs
    MGI:95780
    NCBI Gene: 14687
  • Gene Overview
    MyGene.info: GNAZ
Location & Maps
more
  • Sequence Map
    Chr10:74967177-75016907 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49731 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.48 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GNAZ, G protein subunit alpha z
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNAZ, G protein subunit alpha z
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2781
    neXtProt AC: NX_P19086

  • Chr Location
    22q11.22; chr22:23070483-23125034 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22574
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GNAZ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Gnaz
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033002 VEGA Gene Model | MGI Sequence Detail 49731 C57BL/6J ±  kb
transcript OTTMUST00000082314 VEGA | MGI Sequence Detail 3519 Not Applicable  
polypeptide OTTMUSP00000044104 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    129 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008094 guanine nucleotide-binding protein G(z) subunit alpha
  • InterPro Domains
    IPR001408 G-protein alpha subunit, group I
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 15
    cDNA 11
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10194, MGI:2143685
References
more
  • Summaries
    All 53
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 24
  • Earliest
    J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
  • Latest
    J:218163 Jin S, et al., Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory