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Gnat2
Gene Detail
Symbol

Name
ID
Gnat2
guanine nucleotide binding protein, alpha transducing 2
MGI:95779
Synonyms
Gnat-2, Gt-2, Tcalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:108092789-108101432 bp, + strand
From VEGA annotation of GRCm38

  8644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAT2
Gene Tree: Gnat2

Human
homologs
GNAT2, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2780
neXtProt AC: NX_P19087

Human Synonyms: ACHM4, GNATC

Human Chr (Location): 1p13.1; chr1:109602906-109619662 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNAT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses.
 
Human Diseases Modeled in Mice Using Gnat2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gnat2 interacts with 78 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (33)    Tissues (22)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 7
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnat2 ; ZFIN gnat2    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007183 (Evidence)
Ensembl Gene Model ENSMUSG00000009108 (Evidence)
Entrez Gene 14686 (Evidence)
UniGene 439652
DFCI TC1585090, TC1623865
DoTS DT.101706881, DT.40167180, DT.91355122
NIA Mouse Gene Index U003724
Consensus CDS Project CCDS17750.1
International Mouse Phenotyping Consortium Status Gnat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007183 VEGA Gene Model | MGI Sequence Detail 8644 C57BL/6J ±  kb
transcript OTTMUST00000016571 VEGA | MGI Sequence Detail 2054 Not Applicable 
polypeptide OTTMUSP00000007612 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008092 guanine nucleotide-binding protein G(t) subunit alpha-2
References
(Earliest) J:30928 Lochrie MA, et al., Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science. 1985 Apr 5;228(4695):96-9
(Latest) J:219606 Tikidji-Hamburyan A, et al., Retinal output changes qualitatively with every change in ambient illuminance. Nat Neurosci. 2015 Jan;18(1):66-74
All references(65)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10191, MGD-MRK-10193, MGI:2139985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory