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Gnat2
Gene Detail
 Symbol
Name
ID
Gnat2
guanine nucleotide binding protein, alpha transducing 2
MGI:95779
Synonyms Gnat-2, Gt-2, Tcalpha
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:108092789-108101432 bp, + strand
From VEGA annotation of GRCm38

  8644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnat2

Human
homologs
Human Homolog GNAT2, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
NCBI Gene ID 2780
neXtProt AC  NX_P19087
Human Synonyms  ACHM4, GNATC
Human Chr (Location)  1p13.1; chr1:109603267-109613083 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAT2
Alleles
and
phenotypes
All alleles(7) : Gene trapped(3) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses.
 
Human Diseases Modeled Using Mouse Gnat2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, ...
Component heterotrimeric G-protein complex, membrane, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled photoreceptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (25)    Images (7)
Theiler Stages: 1, 2, 3, 4, 23, 28
Assay TypeResults
RNA in situ 26
RT-PCR 10
cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007183 (Evidence)
Ensembl Gene ModelENSMUSG00000009108 (Evidence)
Entrez Gene14686 (Evidence)
UniGene439652
DFCITC1585090, TC1623865
DoTSDT.101706881, DT.40167180, DT.91355122
NIA Mouse Gene IndexU003724
Consensus CDS ProjectCCDS17750.1
International Mouse Knockout Project StatusGnat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007183 VEGA Gene Model | MGI Sequence Detail 8644 C57BL/6J ±  kb
transcript OTTMUST00000016571 VEGA | MGI Sequence Detail 2054 Not Applicable 
polypeptide OTTMUSP00000007612 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(10) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008092 guanine nucleotide-binding protein G(t) subunit alpha-2
References (Earliest) J:30928 Lochrie MA, et al., Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science. 1985 Apr 5;228(4695):96-9
(Latest) J:207143 Sakami S, et al., P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41
All references(63)
Other
accession IDs
MGD-MRK-10191, MGD-MRK-10193, MGI:2139985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory