Gnat2
Gene Detail

Symbol Name ID

Gnat2 guanine nucleotide binding protein, alpha transducing 2 MGI:95779

Synonyms

Gnat-2, Gt-2, Tcalpha

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:108092789-108101432 bp, + strand From VEGA annotation of GRCm38   8644 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21092  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnat2

Human homologs

Human Homolog		GNAT2, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
NCBI Gene ID		2780
neXtProt AC		NX_P19087
Human Synonyms		ACHM4, GNATC
Human Chr (Location)		1p13.1; chr1:110145889-110155705 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GNAT2

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(3) Spontaneous(1)
 

Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses.

 
Human Diseases Modeled Using Mouse Gnat2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, ...
Component	extrinsic to internal side of plasma membrane, heterotrimeric G-protein complex, ...
Function	G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (25)    Images (7)
Theiler Stages: 1, 2, 3, 4, 23, 28

Assay Type	Results
RNA in situ	26
RT-PCR	10

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007183 (Evidence)
Ensembl Gene Model	ENSMUSG00000009108 (Evidence)
Entrez Gene	14686 (Evidence)
UniGene	439652
DFCI	TC1585090, TC1623865
DoTS	DT.101706881, DT.40167180, DT.91355122
NIA Mouse Gene Index	U003724
Consensus CDS Project	CCDS17750.1
International Mouse Knockout Project Status	Gnat2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007183	VEGA Gene Model | MGI Sequence Detail	8644	C57BL/6J
transcript	OTTMUST00000016571	VEGA | MGI Sequence Detail	2054	Not Applicable
polypeptide	OTTMUSP00000007612	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(47) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001408	G-protein alpha subunit, group I
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000008092	guanine nucleotide-binding protein G(t) subunit alpha-2

References

(Earliest) J:30928 Lochrie MA, et al., Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science. 1985 Apr 5;228(4695):96-9
(Latest) J:191557 Wang YV, et al., Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cells. J Neurosci. 2011 May 25;31(21):7670-81
All references(59)

Other accession IDs

MGD-MRK-10191, MGD-MRK-10193, MGI:2139985