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Gnat1
Gene Detail
Symbol

Name
ID
Gnat1
guanine nucleotide binding protein, alpha transducing 1
MGI:95778
Synonyms
Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr9:107674474-107679712 bp, - strand
From VEGA annotation of GRCm38

  5239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAT1
Gene Tree: Gnat1

Human
homologs
GNAT1, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2779
neXtProt AC: NX_P11488

Human Synonyms: CSNB1G, CSNBAD3, GBT1, GNATR

Human Chr (Location): 3p21; chr3:50191610-50197696 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GNAT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.
 
Phenotype Images(1)
Interactions
Gnat1 interacts with 170 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (21)    Tissues (12)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
RT-PCR 7
cDNA source data(552)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnat1 ; ZFIN gnat1    NEW 
Molecular
reagents
All nucleic(562) Genomic(2) cDNA(556) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050785 (Evidence)
Ensembl Gene Model ENSMUSG00000034837 (Evidence)
Entrez Gene 14685 (Evidence)
UniGene 284853
DFCI TC1573240, TC1737098
DoTS DT.101368709, DT.60102193, DT.97395119
NIA Mouse Gene Index U031321
Consensus CDS Project CCDS23504.1
International Mouse Phenotyping Consortium Status Gnat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050785 VEGA Gene Model | MGI Sequence Detail 5239 C57BL/6J ±  kb
transcript OTTMUST00000128715 VEGA | MGI Sequence Detail 2328 Not Applicable 
polypeptide OTTMUSP00000069224 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008091 guanine nucleotide-binding protein G(t) subunit alpha-1
References
(Earliest) J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
(Latest) J:220383 Xue Y, et al., CRALBP supports the mammalian retinal visual cycle and cone vision. J Clin Invest. 2015 Feb;125(2):727-38
All references(131)
Other
accession IDs
MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory