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Gnat1 Gene Detail
Summary
  • Symbol
    Gnat1
  • Name
    guanine nucleotide binding protein, alpha transducing 1
  • Synonyms
    Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95778
    NCBI Gene: 14685
  • Gene Overview
    MyGene.info: GNAT1
Location & Maps
more
  • Sequence Map
    Chr9:107674474-107679712 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5239 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.86 cM
  • Mapping Data
    24 experiments
Homology
more
  • Human Ortholog
    GNAT1, G protein subunit alpha transducin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNAT1, G protein subunit alpha transducin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNB1G, CSNBAD3, GBT1, GNATR
  • Links
    NCBI Gene ID: 2779
    neXtProt AC: NX_P11488

  • Chr Location
    3p21; chr3:50191610-50197696 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 20084
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GNAT1
  • Gene Tree
    Gnat1
Human Diseases
more
  • Diseases
    2 with human GNAT1 associations

Human Disease Mouse Models
       Night Blindness, Congenital Stationary, Autosomal Dominant 3; CSNBAD3   OMIM: 610444
Night Blindness, Congenital Stationary, Type 1G; CSNB1G   OMIM: 616389
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    47
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    27
  • Tissues
    14
  • cDNA Data
    552
  • Literature Summary
    10
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050785 VEGA Gene Model | MGI Sequence Detail 5239 C57BL/6J ±  kb
transcript OTTMUST00000128715 VEGA | MGI Sequence Detail 2328 Not Applicable  
polypeptide OTTMUSP00000069224 VEGA | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • RFLP
    4
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008091 guanine nucleotide-binding protein G(t) subunit alpha-1
  • InterPro Domains
    IPR001408 G-protein alpha subunit, group I
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 563
    Genomic 2
    cDNA 556
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705
References
more
  • Summaries
    All 138
    Developmental Gene Expression 10
    Gene Ontology 20
    Phenotypes 77
  • Earliest
    J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
  • Latest
    J:230975 Alam NM, et al., Photoreceptor regulation of spatial visual behavior. Invest Ophthalmol Vis Sci. 2015 Mar;56(3):1842-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory