Gnat1 MGI Mouse Gene Detail - MGI:95778 - G protein subunit alpha transducin 1

Symbol

Gnat1
Name

G protein subunit alpha transducin 1
Synonyms

Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin

Feature Type

protein coding gene
IDs

MGI:95778
NCBI Gene: 14685
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:107551636-107556833 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 58.86 cM
Mapping Data

24 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95778	protein coding gene	Chr9:107551636-107556911 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035267	protein coding gene	Chr9:109567690-109572717 (-)
A/J	MGP_AJ_G0035246	protein coding gene	Chr9:105573616-105578643 (-)
AKR/J	MGP_AKRJ_G0035178	protein coding gene	Chr9:108208237-108213264 (-)
BALB/cJ	MGP_BALBcJ_G0035240	protein coding gene	Chr9:105241356-105246383 (-)
C3H/HeJ	MGP_C3HHeJ_G0034950	protein coding gene	Chr9:108605260-108610287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035760	protein coding gene	Chr9:112551095-112556333 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032658	protein coding gene	Chr9:103001275-103006322 (-)
CAST/EiJ	MGP_CASTEiJ_G0034261	protein coding gene	Chr9:108540424-108545449 (-)
CBA/J	MGP_CBAJ_G0034918	protein coding gene	Chr9:116517948-116523200 (-)
DBA/2J	MGP_DBA2J_G0035079	protein coding gene	Chr9:105024873-105029900 (-)
FVB/NJ	MGP_FVBNJ_G0035027	protein coding gene	Chr9:103795325-103800352 (-)
LP/J	MGP_LPJ_G0035155	protein coding gene	Chr9:109762265-109767292 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035066	protein coding gene	Chr9:118133837-118138864 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035781	protein coding gene	Chr9:108480949-108485976 (-)
PWK/PhJ	MGP_PWKPhJ_G0033968	protein coding gene	Chr9:105346449-105351655 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033803	protein coding gene	Chr9:108533829-108538862 (-)
WSB/EiJ	MGP_WSBEiJ_G0034382	protein coding gene	Chr9:108361788-108366815 (-)

Human Ortholog

GNAT1, G protein subunit alpha transducin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNAT1, G protein subunit alpha transducin 1
Synonyms

CSNB1G, CSNBAD3, GBT1, GNATR, HG1F
Links

HGNC:4393

NCBI Gene ID: 2779

UniProt: P11488
Chr Location

3p21.31; chr3:50191610-50197696 (+) GRCh38

MGI Vertebrate Homology

Gnat1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNAT1
Gene Tree

Gnat1

Diseases

3 with human GNAT1 associations

				Human Disease	Mouse Models
				congenital stationary night blindness 1G IDs congenital stationary night blindness 1G DOID:0110714 OMIM:616389
				congenital stationary night blindness autosomal dominant 3 IDs congenital stationary night blindness autosomal dominant 3 DOID:0110715 OMIM:610444
				night blindness IDs night blindness DOID:8499 ICD10CM:H53.6 ICD9CM:368.6 ICD9CM:368.60 MESH:D009755 NCI:C34850 UMLS_CUI:C0028077

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotypes from multigenic genotypes
1 images
151 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

8
Spontaneous

1
Targeted

2
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.

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All GO Annotations

109
GO References

32

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

16
cDNA Data

553
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnat1

ZFIN gnat1

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS23504.1

Ensembl

ENSMUSG00000034837 (Evidence)
NCBI Gene

14685

			Length	Strain/Species	Flank
genomic	14685	NCBI Gene Model \| MGI Sequence Detail	5198	C57BL/6J	± kb
transcript	NM_008140	RefSeq \| MGI Sequence Detail	2296	ZRU/MplStud
polypeptide	P20612	UniProt \| EBI \| MGI Sequence Detail	350	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008091 guanine nucleotide-binding protein G(t) subunit alpha-1

(term hierarchy)
InterPro Domains

IPR001408 G-protein alpha subunit, group I

IPR011025 G protein alpha subunit, helical insertion

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 570

Genomic 2

cDNA 557

Primer pair 7

Other 4

Microarray probesets 3

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MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705

Summaries

All 242

Developmental Gene Expression 25

Gene Ontology 32

Phenotypes 151
Earliest

J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
Latest

J:362943 Bohl JM, et al., Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions. Front Cell Neurosci. 2025;19:1547066

TSS for Gnat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91466	Chr9:107556823-107556839 (-)	2 bp
Tssr91465	Chr9:107553795-107553814 (-)	3,028 bp
Tssr91464	Chr9:107553631-107553647 (-)	3,194 bp
Tssr91463	Chr9:107553601-107553612 (-)	3,226 bp
Tssr91462	Chr9:107553272-107553277 (-)	3,558 bp
Tssr91461	Chr9:107553191-107553199 (-)	3,638 bp
Tssr91460	Chr9:107552851-107552872 (-)	3,971 bp
Tssr91459	Chr9:107552760-107552766 (-)	4,070 bp
Tssr91458	Chr9:107552644-107552653 (-)	4,184 bp
Tssr91457	Chr9:107552489-107552496 (-)	4,340 bp
Tssr91456	Chr9:107552388-107552395 (-)	4,441 bp
Tssr91455	Chr9:107552130-107552136 (-)	4,700 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24