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Gnat1 Gene Detail
Summary
  • Symbol
    Gnat1
  • Name
    guanine nucleotide binding protein, alpha transducing 1
  • Synonyms
    Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95778
    NCBI Gene: 14685
  • Gene Overview
    MyGene.info: GNAT1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107674437-107679634 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.86 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95778
 protein coding gene Chr9:107674437-107679712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035267
 protein coding gene Chr9:109567690-109572717 (-)
A/J MGP_AJ_G0035246
 protein coding gene Chr9:105573616-105578643 (-)
AKR/J MGP_AKRJ_G0035178
 protein coding gene Chr9:108208237-108213264 (-)
BALB/cJ MGP_BALBcJ_G0035240
 protein coding gene Chr9:105241356-105246383 (-)
C3H/HeJ MGP_C3HHeJ_G0034950
 protein coding gene Chr9:108605260-108610287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035760
 protein coding gene Chr9:112551095-112556333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032658
 protein coding gene Chr9:103001275-103006322 (-)
CAST/EiJ MGP_CASTEiJ_G0034261
 protein coding gene Chr9:108540424-108545449 (-)
CBA/J MGP_CBAJ_G0034918
 protein coding gene Chr9:116517948-116523200 (-)
DBA/2J MGP_DBA2J_G0035079
 protein coding gene Chr9:105024873-105029900 (-)
FVB/NJ MGP_FVBNJ_G0035027
 protein coding gene Chr9:103795325-103800352 (-)
LP/J MGP_LPJ_G0035155
 protein coding gene Chr9:109762265-109767292 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035066
 protein coding gene Chr9:118133837-118138864 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035781
 protein coding gene Chr9:108480949-108485976 (-)
PWK/PhJ MGP_PWKPhJ_G0033968
 protein coding gene Chr9:105346449-105351655 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033803
 protein coding gene Chr9:108533829-108538862 (-)
WSB/EiJ MGP_WSBEiJ_G0034382
 protein coding gene Chr9:108361788-108366815 (-)



Homology
more
  • Human Ortholog
    GNAT1, G protein subunit alpha transducin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNAT1, G protein subunit alpha transducin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNB1G, CSNBAD3, GBT1, GNATR
  • Links
    NCBI Gene ID: 2779
    neXtProt AC: NX_P11488
    UniProt: P11488

  • Chr Location
    3p21.31; chr3:50191610-50197696 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 20084
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNAT1
  • Gene Tree
    Gnat1
Human Diseases
more
  • Diseases
    2 with human GNAT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    15
  • cDNA Data
    553
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14685 NCBI Gene Model | MGI Sequence Detail 5198 C57BL/6J ±  kb
    transcript NM_008140 RefSeq | MGI Sequence Detail 2296 C57BL/6  
    polypeptide P20612 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008091 guanine nucleotide-binding protein G(t) subunit alpha-1
      (term hierarchy)
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 565
      Genomic 2
      cDNA 557
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 21
      Gene Ontology 21
      Phenotypes 118
    • Earliest
      J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
    • Latest
      J:292746 Begum M, et al., Stimulus-Driven Retinal Intrinsic Signal Optical Imaging in Mouse Demonstrates a Dominant Rod-Driven Component. Invest Ophthalmol Vis Sci. 2020 Jul 1;61(8):37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/20/2020
    MGI 6.16     		The Jackson Laboratory