Gnat1
Gene Detail

Symbol

Name
ID

Gnat1
guanine nucleotide binding protein, alpha transducing 1
MGI:95778

Synonyms

Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin

Feature Type

protein coding gene

Genetic Map

Chromosome 9
58.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr9:107674474-107679592 bp, - strand From NCBI annotation of GRCm38   5119 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnat1

Human
homologs

Human Homolog		GNAT1, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
NCBI Gene ID		2779
neXtProt AC		NX_P11488
Human Synonyms		CSNBAD3, GBT1, GNATR
Human Chr (Location)		3p21; chr3:50191610-50197696 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GNAT1

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.

 
Phenotype Images(1)

Interactions

Gnat1 interacts with 170 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (49 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell proliferation, ...
Component	apical plasma membrane, cytoplasm, ...
Function	G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (21)    Tissues (12)    Images (27)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	14
RT-PCR	7

cDNA source data(552)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(562) Genomic(2) cDNA(556) Primer pair(2) Other(2)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000034837 (Evidence)
Entrez Gene	14685 (Evidence)
UniGene	284853
DFCI	TC1573240, TC1737098
DoTS	DT.101368709, DT.60102193, DT.97395119
NIA Mouse Gene Index	U031321
Consensus CDS Project	CCDS23504.1
International Mouse Knockout Project Status	Gnat1

Sequences

Length	Strain/Species
genomic	14685	NCBI Gene Model | MGI Sequence Detail	5119	C57BL/6J
transcript	NM_008140	RefSeq | MGI Sequence Detail	2222	Not Specified
polypeptide	P20612	UniProt | EBI | MGI Sequence Detail	350	Not Applicable

All sequences(34) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(4) : SNPs within 2kb(57 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001408	G-protein alpha subunit, group I
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000008091	guanine nucleotide-binding protein G(t) subunit alpha-1

Graphical View of Protein Domain Structure

References

(Earliest) J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
(Latest) J:207143 Sakami S, et al., P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41
All references(129)

Other
accession IDs

MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705