Gnat1
Gene Detail

Symbol Name ID

Gnat1 guanine nucleotide binding protein, alpha transducing 1 MGI:95778

Synonyms

Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin

Feature Type

protein coding gene

Genetic Map

Chromosome 9

58.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr9:107674477-107679592 bp, - strand From Ensembl annotation of GRCm38   5116 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnat1

Human homologs

Human Homolog		GNAT1, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
NCBI Gene ID		2779
neXtProt AC		NX_P11488
Human Synonyms		CSNBAD3, GBT1, GNATR
Human Chr (Location)		3p21; chr3:50191610-50197696 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GNAT1

Alleles and phenotypes

All alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell proliferation, ...
Component	apical plasma membrane, cytoplasm, ...
Function	G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (20)    Tissues (12)    Images (27)
Theiler Stages: 4, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	14
RT-PCR	6

cDNA source data(552)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(561) Genomic(2) cDNA(556) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034837 (Evidence)
Entrez Gene	14685 (Evidence)
UniGene	284853
DFCI	TC1573240, TC1737098
DoTS	DT.101368709, DT.60102193, DT.97395119
NIA Mouse Gene Index	U031321
Consensus CDS Project	CCDS23504.1
International Mouse Knockout Project Status	Gnat1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000034837	Ensembl Gene Model | MGI Sequence Detail	5116	C57BL/6J
transcript	ENSMUST00000010205	Ensembl | MGI Sequence Detail	2205	Not Applicable
polypeptide	ENSMUSP00000010205	Ensembl | MGI Sequence Detail	350	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(4) : SNPs within 2kb(57 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001408	G-protein alpha subunit, group I
InterPro	IPR011025	G protein alpha subunit, helical insertion
InterPro	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000008091	guanine nucleotide-binding protein G(t) subunit alpha-1

References

(Earliest) J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
(Latest) J:207143 Sakami S, et al., P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41
All references(127)

Other accession IDs

MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705