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Gnat1
Gene Detail
 Symbol
Name
ID
Gnat1
guanine nucleotide binding protein, alpha transducing 1
MGI:95778
Synonyms Gnat-1, Ird1, Ird2, irdr, Tralpha, transducin
Feature Type protein coding gene
Genetic Map
Chromosome 9
58.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr9:107674477-107679592 bp, - strand
From Ensembl annotation of GRCm38

  5116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20084  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gnat1

Human
homologs
Human Homolog GNAT1, guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
NCBI Gene ID 2779
neXtProt AC  NX_P11488
Human Synonyms  CSNBAD3, GBT1, GNATR
Human Chr (Location)  3p21; chr3:50191610-50197696 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene display retinal degeneration with age and abnormal electrophysiology of the rods.
 
Phenotype Images(1)
Interactions
Gnat1 interacts with 170 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell proliferation, ...
Component apical plasma membrane, cytoplasm, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (19)    Tissues (12)    Images (27)
Theiler Stages: 4, 20, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 14
RT-PCR 5
cDNA source data(552)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(561) Genomic(2) cDNA(556) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034837 (Evidence)
Entrez Gene14685 (Evidence)
UniGene284853
DFCITC1573240, TC1737098
DoTSDT.101368709, DT.60102193, DT.97395119
NIA Mouse Gene IndexU031321
Consensus CDS ProjectCCDS23504.1
International Mouse Knockout Project StatusGnat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034837 Ensembl Gene Model | MGI Sequence Detail 5116 C57BL/6J ±  kb
transcript ENSMUST00000010205 Ensembl | MGI Sequence Detail 2205 Not Applicable 
polypeptide ENSMUSP00000010205 Ensembl | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms RFLP(4) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008091 guanine nucleotide-binding protein G(t) subunit alpha-1
References (Earliest) J:7875 Tanabe T, et al., Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature. 1985 May 16-22;315(6016):242-5
(Latest) J:207143 Sakami S, et al., P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 1;23(7):1723-41
All references(127)
Other
accession IDs
MGD-MRK-10190, MGD-MRK-10192, MGI:3707703, MGI:3707705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory