Gnal MGI Mouse Gene Detail - MGI:95774 - guanine nucleotide binding protein, alpha stimulating, olfactory type

Symbol

Gnal
Name

guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms

2610011C15Rik, 9630020G10Rik, G alpha 10, Galphaolf, Gna10, Golf

Feature Type

protein coding gene
IDs

MGI:95774
NCBI Gene: 14680
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr18:67221369-67359863 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 39.85 cM
Mapping Data

4 experiments

SNPs within 2kb

4504 from dbSNP Build 142
Strain Annotations

30
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95774	protein coding gene	Chr18:67221287-67359863 (+)
129S1/SvImJ	ENSMUSG00200023859	protein coding gene	Chr18:64461804-64553113 (+)
129S1/SvImJ	ENSMUSGG00200054828	protein coding gene	Chr18:64416939-64418129 (+)
A/J	ENSMUSGG00195055463	protein coding gene	Chr18:64443266-64444456 (+)
A/J	ENSMUSG00195032161	protein coding gene	Chr18:64494849-64586802 (+)
AKR/J	ENSMUSG00220021491	protein coding gene	Chr18:64475917-64567809 (+)
AKR/J	ENSMUSGG00220054551	protein coding gene	Chr18:64431013-64432203 (+)
BALB/cJ	ENSMUSG00180011353	protein coding gene	Chr18:65061962-65153909 (+)
BALB/cJ	ENSMUSGG00180055311	protein coding gene	Chr18:65010206-65011396 (+)
C3H/HeJ	ENSMUSGG00175054825	protein coding gene	Chr18:64634145-64635335 (+)
C3H/HeJ	ENSMUSG00175009853	protein coding gene	Chr18:64679016-64770334 (+)
C57BL/6NJ	ENSMUSGG00215055632	protein coding gene	Chr18:63980929-63982119 (+)
C57BL/6NJ	ENSMUSG00215008510	protein coding gene	Chr18:64025811-64117032 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022363	protein coding gene	Chr18:63781511-63928062 (+)
CAST/EiJ	ENSTCUG00005014933	protein coding gene	Chr18:63665673-63758710 (+)
CBA/J	ENSMUSGG00210054630	protein coding gene	Chr18:64587161-64588351 (+)
CBA/J	ENSMUSG00210028876	protein coding gene	Chr18:64632040-64723355 (+)
DBA/2J	ENSMUSGG00185057592	protein coding gene	Chr18:64498481-64499671 (+)
DBA/2J	ENSMUSG00185029619	protein coding gene	Chr18:64543354-64634662 (+)
FVB/NJ	ENSMUSG00205011822	protein coding gene	Chr18:64005911-64097802 (+)
FVB/NJ	ENSMUSGG00205054374	protein coding gene	Chr18:63961034-63962224 (+)
JF1/MsJ	ENSUMUG00000021294	protein coding gene	Chr18:64458725-64551697 (+)
LP/J	ENSMUSG00230038785	protein coding gene	Chr18:66594304-66685598 (+)
LP/J	ENSMUSGG00230055837	protein coding gene	Chr18:66549438-66550628 (+)
NOD/ShiLtJ	ENSMUSG00190007861	protein coding gene	Chr18:64265759-64357651 (+)
NOD/ShiLtJ	ENSMUSGG00190054671	protein coding gene	Chr18:64220885-64222075 (+)
NZO/HlLtJ	ENSMUSGG00225055405	protein coding gene	Chr18:66438280-66439470 (+)
NZO/HlLtJ	ENSMUSG00225030198	protein coding gene	Chr18:66483158-66575042 (+)
PWK/PhJ	ENSLUMG00010024765	protein coding gene	Chr18:64846189-64936928 (+)
SPRET/EiJ	no annotation
WSB/EiJ	ENSIUOG00005005503	protein coding gene	Chr18:64064253-64156319 (+)

Human Ortholog

GNAL, G protein subunit alpha L

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNAL, G protein subunit alpha L
Synonyms

DYT25, HG1O
Links

HGNC:4388

NCBI Gene ID: 2774

UniProt: P38405
Chr Location

18p11.21; chr18:11689264-11885685 (+) GRCh38

MGI Vertebrate Homology

Gnal stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNAL
Gene Tree

Gnal

Diseases

1 with human GNAL associations

				Human Disease	Mouse Models
				dystonia 25 IDs dystonia 25 DOID:0090055 ICD10CM:G24.1 OMIM:615073 ORDO:329466

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibiting severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors.

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All GO Annotations

36
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

642
Tissues

14
cDNA Data

14
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnal

ZFIN gnal

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All Sequences

82
RefSeq

8
UniProt

10
CCDS

CCDS29317.1, CCDS29318.1

Ensembl

ENSMUSG00000024524 (Evidence)
NCBI Gene

14680

			Length	Strain/Species	Flank
genomic	14680	NCBI Gene Model \| MGI Sequence Detail	138495	C57BL/6J	± kb
transcript	NM_177137	RefSeq \| MGI Sequence Detail	5654	ZRU/MplStud
polypeptide	Q8CGK7	UniProt \| EBI \| MGI Sequence Detail	381	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000008088 guanine nucleotide-binding protein G(olf) subunit alpha

(term hierarchy)
PDB

8HTG
EC

3.6.5.-
InterPro Domains

IPR000367 G-protein alpha subunit, group S

IPR011025 G protein alpha subunit, helical insertion

IPR001019 Guanine nucleotide binding protein, alpha subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q8CGK7 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 21

Genomic 1

cDNA 17

Primer pair 1

Other 2

Antibodies 2

Microarray probesets 6

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MGD-MRK-10174, MGD-MRK-10186, MGI:1919713, MGI:2147266, MGI:2443840, MGI:95765

Summaries

All 88

Developmental Gene Expression 20

Gene Ontology 13

Phenotypes 27
Earliest

J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
Latest

J:381351 Longueville S, et al., Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia. Neurobiol Dis. 2025 Oct 15;215:107071

TSS for Gnal:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151716	Chr18:67221303-67221319 (+)	-58 bp
Tssr151717	Chr18:67221358-67221416 (+)	18 bp
Tssr151718	Chr18:67221419-67221430 (+)	56 bp
Tssr151719	Chr18:67266149-67266157 (+)	44,784 bp
Tssr151720	Chr18:67266168-67266180 (+)	44,805 bp
Tssr151721	Chr18:67266549-67266567 (+)	45,189 bp
Tssr151722	Chr18:67266569-67266606 (+)	45,219 bp
Tssr151723	Chr18:67266618-67266656 (+)	45,268 bp
Tssr151724	Chr18:67266784-67266805 (+)	45,426 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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