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Gnal
Gene Detail
Symbol

Name
ID
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
MGI:95774
Synonyms
2610011C15Rik, 9630020G10Rik, G alpha 10, Galphaolf, Gna10, Golf
Feature Type
protein coding gene
Genetic Map
Chromosome 18
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:67088336-67226792 bp, + strand
From Ensembl annotation of GRCm38

  138457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAL
Gene Tree: Gnal

Human
homologs
GNAL, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2774
neXtProt AC: NX_P38405

Human Synonyms: DYT25

Human Chr (Location): 18p11.22-p11.21; chr18:11689015-11885685 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNAL

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors.
 
Interactions
Gnal interacts with 393 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (15 records)
Data Summary: Results (41)    Tissues (11)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
RT-PCR 5
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnal ; ZFIN gnal    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024524 (Evidence)
Entrez Gene 14680 (Evidence)
DFCI TC1585168, TC1593775, TC1594827, TC1595206, TC1630049, TC1637314, TC1660124
NIA Mouse Gene Index U018837
Consensus CDS Project CCDS29317.1, CCDS29318.1
International Mouse Phenotyping Consortium Status Gnal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024524 Ensembl Gene Model | MGI Sequence Detail 138457 C57BL/6J ±  kb
transcript ENSMUST00000025402 Ensembl | MGI Sequence Detail 5616 Not Applicable 
polypeptide ENSMUSP00000025402 Ensembl | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(1294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000367 G-protein alpha subunit, group S
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008088 guanine nucleotide-binding protein G(olf) subunit alpha
References
(Earliest) J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
(Latest) J:210873 Castro LR, et al., Striatal neurones have a specific ability to respond to phasic dopamine release. J Physiol. 2013 Jul 1;591(Pt 13):3197-214
All references(60)
Other
accession IDs
MGD-MRK-10174, MGD-MRK-10186, MGI:1919713, MGI:2147266, MGI:2443840, MGI:95765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory