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Gnal
Gene Detail
 Symbol
Name
ID
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
MGI:95774
Synonyms 2610011C15Rik, 9630020G10Rik, G alpha 10, Galphaolf, Gna10, Golf
Feature Type protein coding gene
Genetic Map
Chromosome 18
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:67088336-67226792 bp, + strand
From NCBI annotation of GRCm38

  138457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68222  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnal

Human
homologs
Human Homolog GNAL, guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
NCBI Gene ID 2774
neXtProt AC  NX_P38405
Human Synonyms  DYT25
Human Chr (Location)  18p11.22-p11.21; chr18:11689015-11885685 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAL
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process activation of adenylate cyclase activity, adenylate cyclase-activating dopamine receptor signaling pathway, ...
Component heterotrimeric G-protein complex
Function G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (42)    Tissues (12)    Images (20)
Theiler Stages: 4, 22, 23, 24, 28
Assay TypeResults
RNA in situ 36
RT-PCR 6
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(14) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024524 (Evidence)
Entrez Gene14680 (Evidence)
DFCITC1585168, TC1593775, TC1594827, TC1595206, TC1630049, TC1637314, TC1660124
NIA Mouse Gene IndexU018837
Consensus CDS ProjectCCDS29317.1, CCDS29318.1
International Mouse Knockout Project StatusGnal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14680 NCBI Gene Model | MGI Sequence Detail 138457 C57BL/6J ±  kb
transcript NM_177137 RefSeq | MGI Sequence Detail 5654 C57BL/6 
polypeptide Q8CGK7 UniProt | EBI | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(1294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000367 G-protein alpha subunit, group S
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008088 guanine nucleotide-binding protein G(olf) subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
(Latest) J:210873 Castro LR, et al., Striatal neurones have a specific ability to respond to phasic dopamine release. J Physiol. 2013 Jul 1;591(Pt 13):3197-214
All references(60)
Other
accession IDs
MGD-MRK-10174, MGD-MRK-10186, MGI:1919713, MGI:2147266, MGI:2443840, MGI:95765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory