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Gnai3
Gene Detail
 Symbol
Name
ID
Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
MGI:95773
Synonyms Galphai3
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:108107280-108146146 bp, - strand
From VEGA annotation of GRCm38

  38867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55975  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gnai3

Human
homologs
Human Homolog GNAI3, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
NCBI Gene ID 2773
neXtProt AC  NX_P08754
Human Synonyms  87U6, ARCND1
Human Chr (Location)  1p13; chr1:109548564-109595843 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNAI3
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal basal cardiac function and beta-adrenergic sensitivity. Mice homozygous for a different knock-out allele exhibit enhanced T cell migration toward CXCR3 agonists.
 
Phenotype Images(3)
Interactions
Gnai3 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell cycle, ...
Component centrosome, cytoplasm, ...
Function G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (9)    Images (1)
Theiler Stages: 1, 2, 3, 4, 28
Assay TypeResults
RT-PCR 10
cDNA source data(394)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(397) cDNA(396) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000007197 (Evidence)
Ensembl Gene ModelENSMUSG00000000001 (Evidence)
Entrez Gene14679 (Evidence)
UniGene271703
DFCITC1573928, TC1745184, TC1769320
DoTSDT.101405601, DT.532584, DT.94409713, DT.97373553
NIA Mouse Gene IndexU024517
PDB3AB3
Consensus CDS ProjectCCDS17751.1
International Mouse Knockout Project StatusGnai3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007197 VEGA Gene Model | MGI Sequence Detail 38867 C57BL/6J ±  kb
transcript OTTMUST00000016610 VEGA | MGI Sequence Detail 3262 Not Applicable 
polypeptide OTTMUSP00000007641 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(150 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008087 guanine nucleotide-binding protein G(k) subunit alpha
References (Earliest) J:13713 Frels W, et al., Linkage of glutathione reductase (Gr). Mouse News Lett. 1977;56:58
(Latest) J:209809 Diehl SA, et al., G proteins Galphai1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Infect Immun. 2014 Feb;82(2):773-82
All references(75)
Other
accession IDs
MGD-MRK-10182, MGD-MRK-10185, MGI:2139639, MGI:2139991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory