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Gnai3
Gene Detail
Symbol

Name
ID
Gnai3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
MGI:95773
Synonyms
Galphai3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:108107280-108146146 bp, - strand
From VEGA annotation of GRCm38

  38867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55975  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAI3
Gene Tree: Gnai3

Human
homologs
GNAI3, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2773
neXtProt AC: NX_P08754

Human Synonyms: 87U6, ARCND1

Human Chr (Location): 1p13; chr1:109548564-109595843 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNAI3

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal basal cardiac function and beta-adrenergic sensitivity. Mice homozygous for a different knock-out allele exhibit enhanced T cell migration toward CXCR3 agonists.
 
Phenotype Images(3)
Interactions
Gnai3 interacts with 264 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (7)    Tissues (6)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 7
cDNA source data(394)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnai3    NEW 
Molecular
reagents
All nucleic(397) cDNA(396) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000007197 (Evidence)
Ensembl Gene Model ENSMUSG00000000001 (Evidence)
Entrez Gene 14679 (Evidence)
UniGene 271703
DFCI TC1573928, TC1745184, TC1769320
DoTS DT.101405601, DT.532584, DT.94409713, DT.97373553
NIA Mouse Gene Index U024517
PDB 3AB3
Consensus CDS Project CCDS17751.1
International Mouse Phenotyping Consortium Status Gnai3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007197 VEGA Gene Model | MGI Sequence Detail 38867 C57BL/6J ±  kb
transcript OTTMUST00000016610 VEGA | MGI Sequence Detail 3262 Not Applicable 
polypeptide OTTMUSP00000007641 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(150 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008087 guanine nucleotide-binding protein G(k) subunit alpha
References
(Earliest) J:13713 Frels W, et al., Linkage of glutathione reductase (Gr). Mouse News Lett. 1977;56:58
(Latest) J:221651 Devanathan V, et al., Platelet Gi protein Galphai2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6
All references(79)
Other
accession IDs
MGD-MRK-10182, MGD-MRK-10185, MGI:2139639, MGI:2139991

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory