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Gnai1
Gene Detail
Symbol

Name
ID
Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
MGI:95771
Synonyms
Gialpha1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
8.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:18265135-18360413 bp, - strand
From NCBI annotation of GRCm38

  95279 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNAI1
Gene Tree: Gnai1

Human
homologs
GNAI1, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2770
neXtProt AC: NX_P63096

Human Synonyms: Gi

Human Chr (Location): 7q21; chr7:80134824-80219409 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene exhibit long term memory defects.
 
Phenotype Images(1)
Interactions
Gnai1 interacts with 303 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell cycle, ...
Component centrosome, cytoplasm, ...
Function GDP binding, G-protein beta/gamma-subunit complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (17)    Tissues (10)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
RT-PCR 9
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GNAI1 ; Xenbase gnai1 ; ZFIN gnai1    NEW 
Molecular
reagents
All nucleic(59) cDNA(54) Primer pair(4) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000057614 (Evidence)
Entrez Gene 14677 (Evidence)
UniGene 254629
DFCI TC1639270, TC1678212, TC1771360
DoTS DT.532580
NIA Mouse Gene Index U025953
Consensus CDS Project CCDS39018.1
International Mouse Phenotyping Consortium Status Gnai1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14677 NCBI Gene Model | MGI Sequence Detail 95279 C57BL/6J ±  kb
transcript NM_010305 RefSeq | MGI Sequence Detail 3193 C57BL/6 
polypeptide B2RSH2 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001408 G-protein alpha subunit, group I
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008085 guanine nucleotide-binding protein G(i) subunit alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:8410 Sullivan KA, et al., Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91
(Latest) J:220534 Li X, et al., Galphai1 and Galphai3 regulate macrophage polarization by forming a complex containing CD14 and Gab1. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4731-6
All references(63)
Other
accession IDs
MGD-MRK-10180, MGD-MRK-10183, MGI:2141096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory