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Gna13
Gene Detail
 Symbol
Name
ID
Gna13
guanine nucleotide binding protein, alpha 13
MGI:95768
Synonyms Galpha13
Feature Type protein coding gene
Genetic Map
Chromosome 11
71.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:109362831-109401369 bp, + strand
From VEGA annotation of GRCm38

  38539 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gna13

Human
homologs
Human Homolog GNA13, guanine nucleotide binding protein (G protein), alpha 13
NCBI Gene ID 10672
neXtProt AC  NX_Q14344
Human Synonyms  G13
Human Chr (Location)  17q24.3; chr17:65009289-65056802 (-)  GRCh38
Alleles
and
phenotypes
All alleles(26) : Gene trapped(17) Targeted(9)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null or with an endothelial specific conditional mutation fail to develop an organized vascular system in the yolk sac, show impaired vascular development in some vascular beds in the embryo proper, and die during organogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process activation of phospholipase D activity, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component brush border membrane, cytoplasm, ...
Function D5 dopamine receptor binding, G-protein beta/gamma-subunit complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (78)    Tissues (68)    Images (14)
Theiler Stages: 1, 2, 3, 4, 9, 11, 13, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 65
RT-PCR 13
cDNA source data(222)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(227) cDNA(223) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000003357 (Evidence)
Ensembl Gene ModelENSMUSG00000020611 (Evidence)
Entrez Gene14674 (Evidence)
UniGene193925
DFCITC1576904, TC1586459, TC1587902, TC1600035, TC1645384, TC1652578
DoTSDT.101156381, DT.493196, DT.493197
NIA Mouse Gene IndexU043241
PDB1SHZ, 1ZCB, 3AB3, 3CX6, 3CX7, 3CX8
Consensus CDS ProjectCCDS25577.1
International Mouse Knockout Project StatusGna13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003357 VEGA Gene Model | MGI Sequence Detail 38539 C57BL/6J ±  kb
transcript OTTMUST00000007058 VEGA | MGI Sequence Detail 6160 Not Applicable 
polypeptide OTTMUSP00000003361 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(309 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000469 G-protein alpha subunit, group 12
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008082 guanine nucleotide-binding protein subunit alpha-13
References (Earliest) J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
(Latest) J:206486 Rusu L, et al., G protein-dependent basal and evoked endothelial cell vWF secretion. Blood. 2014 Jan 16;123(3):442-50
All references(78)
Other
accession IDs
MGD-MRK-10177, MGI:2144419, MGI:2144437

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory