About   Help   FAQ
Gna12 Gene Detail
Summary
  • Symbol
    Gna12
  • Name
    guanine nucleotide binding protein, alpha 12
  • Synonyms
    Galpha12
  • Feature Type
    protein coding gene
  • IDs
    MGI:95767
    NCBI Gene: 14673
  • Gene Overview
    MyGene.info: GNA12
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140759944-140830431 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95767
protein coding gene Chr5:140758408-140830431 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030307
protein coding gene Chr5:145884731-145956624 (-)
A/J MGP_AJ_G0030276
protein coding gene Chr5:139646310-139719072 (-)
AKR/J MGP_AKRJ_G0030208
protein coding gene Chr5:144008936-144080866 (-)
BALB/cJ MGP_BALBcJ_G0030293
protein coding gene Chr5:140895141-140967906 (-)
C3H/HeJ MGP_C3HHeJ_G0030004
protein coding gene Chr5:144815449-144893466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030738
protein coding gene Chr5:151276719-151348597 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027956
protein coding gene Chr5:133477286-133551517 (-)
CAST/EiJ MGP_CASTEiJ_G0029409
protein coding gene Chr5:144240575-144312054 (-)
CBA/J MGP_CBAJ_G0029974
protein coding gene Chr5:157462965-157535326 (-)
DBA/2J MGP_DBA2J_G0030124
protein coding gene Chr5:139459352-139529078 (-)
FVB/NJ MGP_FVBNJ_G0030079
protein coding gene Chr5:138613790-138686238 (-)
LP/J MGP_LPJ_G0030210
protein coding gene Chr5:146490229-146561087 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030110
protein coding gene Chr5:160059350-160131279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030778
protein coding gene Chr5:143848345-143920610 (-)
PWK/PhJ MGP_PWKPhJ_G0029124
protein coding gene Chr5:138485330-138555493 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028960
protein coding gene Chr5:141557142-141628989 (-)
WSB/EiJ MGP_WSBEiJ_G0029483
protein coding gene Chr5:144649128-144718906 (-)



Homology
more
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GNA12, G protein subunit alpha 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    gep, NNX3, RMP
  • Links
    NCBI Gene ID: 2768
    neXtProt AC: NX_Q03113
    UniProt: Q03113

  • Chr Location
    7p22.3-p22.2; chr7:2728105-2870656 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    36 phenotype references
Mice deficient for this gene do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14673 NCBI Gene Model | MGI Sequence Detail 70488 C57BL/6J ±  kb
transcript NM_010302 RefSeq | MGI Sequence Detail 1880 C57BL/6  
polypeptide P27600 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008081 guanine nucleotide-binding protein subunit alpha-12
  • PDB
  • InterPro Domains
    IPR000469 G-protein alpha subunit, group 12/13
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 13
    Genomic 2
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10176, MGI:2140857, MGI:2140922
References
more
  • Summaries
    All 79
    Developmental Gene Expression 9
    Gene Ontology 11
    Phenotypes 36
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:259333 John AE, et al., Loss of epithelial Gq and G11 signaling inhibits TGFbeta production but promotes IL-33-mediated macrophage polarization and emphysema. Sci Signal. 2016 Oct 25;9(451):ra104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/27/2018
MGI 6.13
The Jackson Laboratory