About   Help   FAQ
Gna12 Gene Detail
Summary
  • Symbol
    Gna12
  • Name
    guanine nucleotide binding protein, alpha 12
  • Synonyms
    Galpha12
  • Feature Type
    protein coding gene
  • IDs
    MGI:95767
    NCBI Gene: 14673
  • Gene Overview
    MyGene.info: GNA12
Location & Maps
more
  • Sequence Map
    Chr5:140758408-140830431 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.30 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GNA12, G protein subunit alpha 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    gep, NNX3, RMP
  • Links
    NCBI Gene ID: 2768
    neXtProt AC: NX_Q03113

  • Chr Location
    7p22.2; chr7:2728105-2870656 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    32 phenotype references
  • All Mutations and Alleles
    18
  • Gene trapped
    14
  • Targeted
    4
  • Incidental Mutations
Mice deficient for this gene do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024795 VEGA Gene Model | MGI Sequence Detail 72024 C57BL/6J ±  kb
transcript OTTMUST00000061066 VEGA | MGI Sequence Detail 3416 Not Applicable  
polypeptide OTTMUSP00000029883 VEGA | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    358 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008081 guanine nucleotide-binding protein subunit alpha-12
  • PDB
  • InterPro Domains
    IPR000469 G-protein alpha subunit, group 12/13
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10176, MGI:2140857, MGI:2140922
References
more
  • Summaries
    All 67
    Developmental Gene Expression 8
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:222537 Yang YM, et al., Galpha12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene. 2015 May 28;34(22):2910-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory