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Gnl1 Gene Detail
Summary
  • Symbol
    Gnl1
  • Name
    guanine nucleotide binding protein-like 1
  • Synonyms
    Gnal1, Gna-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95764
    NCBI Gene: 14670
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35979955-35989462 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.82 cM, cytoband C-D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95764
protein coding gene Chr17:35979851-35989462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023665
protein coding gene Chr17:36200842-36209218 (+)
A/J MGP_AJ_G0023620
protein coding gene Chr17:35074186-35083984 (+)
AKR/J MGP_AKRJ_G0023590
protein coding gene Chr17:35512925-35522517 (+)
BALB/cJ MGP_BALBcJ_G0023625
protein coding gene Chr17:35213838-35222523 (+)
C3H/HeJ MGP_C3HHeJ_G0023391
protein coding gene Chr17:35963772-35976597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024067
protein coding gene Chr17:37680097-37693802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021547
protein coding gene Chr17:33058455-33068125 (+)
CAST/EiJ MGP_CASTEiJ_G0022882
protein coding gene Chr17:36083243-36096579 (+)
CBA/J MGP_CBAJ_G0023369
protein coding gene Chr17:39258659-39269338 (+)
DBA/2J MGP_DBA2J_G0023493
protein coding gene Chr17:34372291-34381845 (+)
FVB/NJ MGP_FVBNJ_G0023464
protein coding gene Chr17:34170556-34179919 (+)
LP/J MGP_LPJ_G0023573
protein coding gene Chr17:36572692-36584546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023485
protein coding gene Chr17:38029358-38037989 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024110
protein coding gene Chr17:35817127-35826481 (+)
PWK/PhJ MGP_PWKPhJ_G0022633
protein coding gene Chr17:33231397-33242113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022452
protein coding gene Chr17:33858843-33868806 (+)
WSB/EiJ MGP_WSBEiJ_G0022948
protein coding gene Chr17:35966341-35975807 (+)



Homology
more
  • Human Ortholog
    GNL1, G protein nucleolar 1 (putative)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNL1, G protein nucleolar 1 (putative)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSR1
  • Links
    NCBI Gene ID: 2794
    neXtProt AC: NX_P36915
    UniProt: P36915

  • Chr Location
    6p21.33; chr6:30541377-30557594 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14670 NCBI Gene Model | MGI Sequence Detail 9508 C57BL/6J ±  kb
transcript NM_008136 RefSeq | MGI Sequence Detail 2744 C57BL/6  
polypeptide P36916 UniProt | EBI | MGI Sequence Detail 607 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008115 guanine nucleotide-binding protein-like 1
  • InterPro Domains
    IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
    IPR006073 GTP binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10173
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:4516 Denizot F, et al., YAC-assisted cloning of a putative G-protein mapping to the MHC class I region [published erratum appears in Genomics 1993 Sep;17(3):800]. Genomics. 1992 Dec;14(4):857-62
  • Latest
    J:229077 Anderson JG, et al., Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab. 2015 Nov;4(11):846-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory