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Gnl1 Gene Detail
Summary
  • Symbol
    Gnl1
  • Name
    guanine nucleotide binding protein-like 1
  • Synonyms
    Gnal1, Gna-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95764
    NCBI Gene: 14670
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35979955-35989462 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.82 cM, cytoband C-D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95764
protein coding gene Chr17:35979851-35989462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023665
protein coding gene Chr17:36200842-36209218 (+)
A/J MGP_AJ_G0023620
protein coding gene Chr17:35074186-35083984 (+)
AKR/J MGP_AKRJ_G0023590
protein coding gene Chr17:35512925-35522517 (+)
BALB/cJ MGP_BALBcJ_G0023625
protein coding gene Chr17:35213838-35222523 (+)
C3H/HeJ MGP_C3HHeJ_G0023391
protein coding gene Chr17:35963772-35976597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024067
protein coding gene Chr17:37680097-37693802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021547
protein coding gene Chr17:33058455-33068125 (+)
CAST/EiJ MGP_CASTEiJ_G0022882
protein coding gene Chr17:36083243-36096579 (+)
CBA/J MGP_CBAJ_G0023369
protein coding gene Chr17:39258659-39269338 (+)
DBA/2J MGP_DBA2J_G0023493
protein coding gene Chr17:34372291-34381845 (+)
FVB/NJ MGP_FVBNJ_G0023464
protein coding gene Chr17:34170556-34179919 (+)
LP/J MGP_LPJ_G0023573
protein coding gene Chr17:36572692-36584546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023485
protein coding gene Chr17:38029358-38037989 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024110
protein coding gene Chr17:35817127-35826481 (+)
PWK/PhJ MGP_PWKPhJ_G0022633
protein coding gene Chr17:33231397-33242113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022452
protein coding gene Chr17:33858843-33868806 (+)
WSB/EiJ MGP_WSBEiJ_G0022948
protein coding gene Chr17:35966341-35975807 (+)



Homology
more
  • Human Ortholog
    GNL1, G protein nucleolar 1 (putative)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GNL1, G protein nucleolar 1 (putative)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSR1
  • Links
    NCBI Gene ID: 2794
    neXtProt AC: NX_P36915
    UniProt: P36915

  • Chr Location
    6p21.33; chr6:30541377-30557594 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3862
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14670 NCBI Gene Model | MGI Sequence Detail 9508 C57BL/6J ±  kb
    transcript NM_008136 RefSeq | MGI Sequence Detail 2744 C57BL/6  
    polypeptide P36916 UniProt | EBI | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008115 guanine nucleotide-binding protein-like 1
    • InterPro Domains
      IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
      IPR006073 GTP binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10173
    References
    more
    • Summaries
      All 33
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:4516 Denizot F, et al., YAC-assisted cloning of a putative G-protein mapping to the MHC class I region [published erratum appears in Genomics 1993 Sep;17(3):800]. Genomics. 1992 Dec;14(4):857-62
    • Latest
      J:254343 Ioris RM, et al., SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep. 2017 Feb 21;18(8):1858-1868

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    05/19/2020
    MGI 6.15
    The Jackson Laboratory