Gnl1 MGI Mouse Gene Detail - MGI:95764 - guanine nucleotide binding protein-like 1

Symbol

Gnl1
Name

guanine nucleotide binding protein-like 1
Synonyms

Gnal1, Gna-rs1

Feature Type

protein coding gene
IDs

MGI:95764
NCBI Gene: 14670
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr17:36290847-36300354 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.82 cM, cytoband C-D
Mapping Data

2 experiments

SNPs within 2kb

2 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95764	protein coding gene	Chr17:36290743-36300354 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023665	protein coding gene	Chr17:36200842-36209218 (+)
A/J	MGP_AJ_G0023620	protein coding gene	Chr17:35074186-35083984 (+)
AKR/J	MGP_AKRJ_G0023590	protein coding gene	Chr17:35512925-35522517 (+)
BALB/cJ	MGP_BALBcJ_G0023625	protein coding gene	Chr17:35213838-35222523 (+)
C3H/HeJ	MGP_C3HHeJ_G0023391	protein coding gene	Chr17:35963772-35976597 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024067	protein coding gene	Chr17:37680097-37693802 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021547	protein coding gene	Chr17:33058455-33068125 (+)
CAST/EiJ	MGP_CASTEiJ_G0022882	protein coding gene	Chr17:36083243-36096579 (+)
CBA/J	MGP_CBAJ_G0023369	protein coding gene	Chr17:39258659-39269338 (+)
DBA/2J	MGP_DBA2J_G0023493	protein coding gene	Chr17:34372291-34381845 (+)
FVB/NJ	MGP_FVBNJ_G0023464	protein coding gene	Chr17:34170556-34179919 (+)
LP/J	MGP_LPJ_G0023573	protein coding gene	Chr17:36572692-36584546 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023485	protein coding gene	Chr17:38029358-38037989 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024110	protein coding gene	Chr17:35817127-35826481 (+)
PWK/PhJ	MGP_PWKPhJ_G0022633	protein coding gene	Chr17:33231397-33242113 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022452	protein coding gene	Chr17:33858843-33868806 (+)
WSB/EiJ	MGP_WSBEiJ_G0022948	protein coding gene	Chr17:35966341-35975807 (+)

Human Ortholog

GNL1, G protein nucleolar 1 (putative)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNL1, G protein nucleolar 1 (putative)
Synonyms

HSR1
Links

HGNC:4413

NCBI Gene ID: 2794

neXtProt AC: NX_P36915

UniProt: P36915
Chr Location

6p21.33; chr6:30541381-30556489 (-) GRCh38

MGI Vertebrate Homology

Gnl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNL1
Gene Tree

Gnl1

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Transgenic

1
Genomic Mutations

1 involving Gnl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnl1

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS37606.1

Ensembl

ENSMUSG00000024429 (Evidence)
NCBI Gene

14670

			Length	Strain/Species	Flank
genomic	14670	NCBI Gene Model \| MGI Sequence Detail	9508	C57BL/6J	± kb
transcript	NM_008136	RefSeq \| MGI Sequence Detail	2744	ZRU/MplStud
polypeptide	P36916	UniProt \| EBI \| MGI Sequence Detail	607	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008115 guanine nucleotide-binding protein-like 1

(term hierarchy)
InterPro Domains

IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

IPR006073 GTP binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR043358 Ras GTPase GNL1-like

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGD-MRK-10173

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:4516 Denizot F, et al., YAC-assisted cloning of a putative G-protein mapping to the MHC class I region [published erratum appears in Genomics 1993 Sep;17(3):800]. Genomics. 1992 Dec;14(4):857-62
Latest

J:337834 Lee MJ, et al., Sirt6 Activation Ameliorates Inflammatory Bone Loss in Ligature-Induced Periodontitis in Mice. Int J Mol Sci. 2023 Jun 27;24(13)

TSS for Gnl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144484	Chr17:36290446-36290455 (+)	-396 bp
Tssr144485	Chr17:36290456-36290483 (+)	-377 bp
Tssr144486	Chr17:36290799-36290816 (+)	-39 bp
Tssr144487	Chr17:36290823-36290901 (+)	15 bp
Tssr144488	Chr17:36290972-36290983 (+)	131 bp
Tssr144489	Chr17:36291006-36291025 (+)	169 bp
Tssr144490	Chr17:36291295-36291318 (+)	460 bp
Tssr144491	Chr17:36291338-36291347 (+)	496 bp
Tssr144492	Chr17:36291748-36291764 (+)	909 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23