Slc6a9
Gene Detail

Symbol Name ID

Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 MGI:95760

Synonyms

Glyt1, Glyt-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:117834506-117875198 bp, + strand From VEGA annotation of GRCm38   40693 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc6a9 ± 2 cM)

Gene Tree: Slc6a9

Human ortholog

SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 NCBI Gene ID 6536
Human Synonyms: GLYT1
Human Chr1:44462155-44497134 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygous null mice die shortly after birth exhibiting breathing and movement deficiencies.

 
Human Diseases Modeled Using Mouse Slc6a9 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	glycine transmembrane transporter activity, neurotransmitter:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (324)    Tissues (155)    Images (82)
Theiler Stages: 1, 2, 3, 4, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	145
In situ reporter (knock in)	72
RT-PCR	94
RNase protection	13

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(5) cDNA(15) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008656 (Evidence)
Ensembl Gene Model	ENSMUSG00000028542 (Evidence)
Entrez Gene	14664 (Evidence)
DFCI	TC1576555, TC1625558, TC1777042
Consensus CDS Project	CCDS18538.1
International Mouse Knockout Project Status	Slc6a9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008656	VEGA Gene Model | MGI Sequence Detail	40693	C57BL/6J
transcript	OTTMUST00000090034	VEGA | MGI Sequence Detail	2107	Not Applicable
polypeptide	OTTMUSP00000049290	VEGA | MGI Sequence Detail	637	Not Applicable

All sequences(71) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR003028	Sodium:neurotransmitter symporter, glycine, type 1
Protein Ontology	PR:000015193	sodium- and chloride-dependent glycine transporter 1

References

(Earliest) J:1378 Liu QR, et al., Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. 1992 Jun 29;305(2):110-4
(Latest) J:185070 Dubroqua S, et al., Intact working memory in the absence of forebrain neuronal glycine transporter 1. Behav Brain Res. 2012 Apr 21;230(1):208-14
All references(70)

Other accession IDs

MGD-MRK-10166, MGD-MRK-10167