About   Help   FAQ
Slc6a9 Gene Detail
Summary
  • Symbol
    Slc6a9
  • Name
    solute carrier family 6 (neurotransmitter transporter, glycine), member 9
  • Synonyms
    Glyt1, Glyt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95760
    NCBI Gene: 14664
  • Gene Overview
    MyGene.info: SLC6A9
Location & Maps
more
  • Sequence Map
    Chr4:117834506-117875198 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC6A9, solute carrier family 6 member 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC6A9, solute carrier family 6 member 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLYT1
  • Links
    NCBI Gene ID: 6536
    neXtProt AC: NX_P48067

  • Chr Location
    1p34.1; chr1:43996483-44031492 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5050
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC6A9
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc6a9 mouse models

Human Disease Mouse Models
       Glycine Encephalopathy; GCE   OMIM: 605899 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    4 involving Slc6a9
  • Incidental Mutations
Homozygous null mice die shortly after birth exhibiting breathing and movement deficiencies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008656 VEGA Gene Model | MGI Sequence Detail 40693 C57BL/6J ±  kb
transcript OTTMUST00000090034 VEGA | MGI Sequence Detail 2107 Not Applicable  
polypeptide OTTMUSP00000049290 VEGA | MGI Sequence Detail 637 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    222 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000015193 sodium- and chloride-dependent glycine transporter 1
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR003028 Sodium:neurotransmitter symporter, glycine, type 1
Molecular
Reagents
less
  • All nucleic 23
    Genomic 5
    cDNA 15
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10166, MGD-MRK-10167
References
more
  • Summaries
    All 77
    Developmental Gene Expression 30
    Diseases 1
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:1378 Liu QR, et al., Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. 1992 Jun 29;305(2):110-4
  • Latest
    J:235721 Menuchin-Lasowski Y, et al., Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development. 2016 Aug 1;143(15):2829-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory