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Slc2a3 Gene Detail
Summary
  • Symbol
    Slc2a3
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 3
  • Synonyms
    Glut3, Glut-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95757
    NCBI Gene: 20527
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122727809-122801640 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.82 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95757
protein coding gene Chr6:122727809-122802274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031232
protein coding gene Chr6:125835648-125917166 (-)
A/J MGP_AJ_G0031201
protein coding gene Chr6:121071373-121151367 (-)
AKR/J MGP_AKRJ_G0031131
protein coding gene Chr6:124418737-124499070 (-)
BALB/cJ MGP_BALBcJ_G0031211
protein coding gene Chr6:120782484-120859142 (-)
C3H/HeJ MGP_C3HHeJ_G0030930
protein coding gene Chr6:124380615-124466261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031670
protein coding gene Chr6:129161581-129241958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028827
protein coding gene Chr6:117676705-117730796 (-)
CAST/EiJ MGP_CASTEiJ_G0030319
protein coding gene Chr6:124647416-124728363 (-)
CBA/J MGP_CBAJ_G0030893
protein coding gene Chr6:134190977-134269502 (-)
DBA/2J MGP_DBA2J_G0031049
protein coding gene Chr6:119999047-120077098 (-)
FVB/NJ MGP_FVBNJ_G0031002
protein coding gene Chr6:118941078-119014119 (-)
LP/J MGP_LPJ_G0031130
protein coding gene Chr6:126026493-126110837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031037
protein coding gene Chr6:138145766-138235401 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031700
protein coding gene Chr6:124312697-124393221 (-)
PWK/PhJ MGP_PWKPhJ_G0030033
protein coding gene Chr6:118843292-118897744 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029861
protein coding gene Chr6:122451186-122536680 (-)
WSB/EiJ MGP_WSBEiJ_G0030401
protein coding gene Chr6:124626035-124707021 (-)



Homology
more
  • Human Ortholog
    SLC2A3, solute carrier family 2 member 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC2A3, solute carrier family 2 member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUT3
  • Links
    NCBI Gene ID: 6515
    neXtProt AC: NX_P11169
    UniProt: P11169

  • Chr Location
    12p13.31; chr12:7919228-7936296 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74302
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC2A3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutations cause embryonic lethality. Heterozygotes for a null allele show partial perinatal lethality and impaired placental transport. Heterozygotes for a gene trap allele show abnormal brain wave patterns, increased startle reflex, reduced prepulse inhibition and increased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003153 Ensembl Gene Model | MGI Sequence Detail 73832 C57BL/6J ±  kb
    transcript ENSMUST00000032476 Ensembl | MGI Sequence Detail 3959 Not Applicable  
    polypeptide ENSMUSP00000032476 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 3
      cDNA 26
      Primer pair 7

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10157, MGD-MRK-10161, MGI:1353648, MGI:1889340, MGI:2141536, MGI:2141541, MGI:2141583
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 37
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:9395 Kayano T, et al., Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem. 1988 Oct 25;263(30):15245-8
    • Latest
      J:258670 Mahany EB, et al., Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory