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Slc2a1
Gene Detail
 Symbol
Name
ID
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
MGI:95755
Synonyms Glut1, Glut-1
Feature Type protein coding gene
Genetic Map
Chromosome 4
55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr4:119108711-119137330 bp, + strand
From VEGA annotation of GRCm38

  28620 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc2a1

Human
homologs
Human Homolog SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1
NCBI Gene ID 6513
neXtProt AC  NX_P11166
Human Synonyms  DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED
Human Chr (Location)  1p34.2; chr1:42925375-42959176 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human SLC2A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(69) : Gene trapped(65) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos are small, lack visibly detectable eyes, show a diminutive rostral embryonic pole and an overall developmental delay, and die at E10-E14. Heterozygotes show spontaneous seizures, impaired motor performance, hypoglycorrhachia, microencephaly, and reduced brain glucose uptake.
 
Phenotype Images(1)
Interactions
Slc2a1 interacts with 199 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process carbohydrate transport, cellular response to glucose starvation, ...
Component basolateral plasma membrane, blood microparticle, ...
Function dehydroascorbic acid transporter activity, D-glucose transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (72 records)
Data Summary: Results (466)    Tissues (119)    Images (64)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 15, 17, 20, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 253
Northern blot 25
Western blot 17
RT-PCR 169
cDNA source data(309)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(328) Genomic(3) cDNA(312) Primer pair(11) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008836 (Evidence)
Ensembl Gene ModelENSMUSG00000028645 (Evidence)
Entrez Gene20525 (Evidence)
UniGene21002
DFCITC1573138
DoTSDT.97383818
NIA Mouse Gene IndexU004733
Consensus CDS ProjectCCDS18569.1
International Mouse Knockout Project StatusSlc2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008836 VEGA Gene Model | MGI Sequence Detail 28620 C57BL/6J ±  kb
transcript OTTMUST00000020092 VEGA | MGI Sequence Detail 2607 Not Applicable 
polypeptide OTTMUSP00000009212 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(7)
Polymorphisms RFLP(6) : SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR002439 Glucose transporter, type 1 (GLUT1)
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015058 solute carrier family 2, facilitated glucose transporter member 1
References (Earliest) J:16692 Kaestner KH, et al., Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(13):4937]. Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4
(Latest) J:210231 Caro-Maldonado A, et al., Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr 15;192(8):3626-36
All references(188)
Other
accession IDs
MGD-MRK-10155, MGD-MRK-10159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory