Slc2a1
Gene Detail

Symbol Name ID

Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 MGI:95755

Synonyms

Glut1, Glut-1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)

Sequence Map

Chr4:119108711-119137330 bp, + strand From VEGA annotation of GRCm38   28620 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc2a1

Human homologs

Human Homolog		SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1
NCBI Gene ID		6513
neXtProt AC		NX_P11166
Human Synonyms		DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED
Human Chr (Location)		1p34.2; chr1:42925375-42959176 (-)  GRCh38
Disease Associations		(4) Diseases Associated with Human SLC2A1

Alleles and phenotypes

All alleles(69) : Gene trapped(65) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null embryos are small, lack visibly detectable eyes, show a diminutive rostral embryonic pole and an overall developmental delay, and die at E10-E14. Heterozygotes show spontaneous seizures, impaired motor performance, hypoglycorrhachia, microencephaly, and reduced brain glucose uptake.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	carbohydrate transport, cellular response to glucose starvation, ...
Component	basolateral plasma membrane, blood microparticle, ...
Function	dehydroascorbic acid transporter activity, D-glucose transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (72 records)

Data Summary: Results (475)    Tissues (121)    Images (64)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 15, 17, 20, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	253
Northern blot	25
Western blot	21
RT-PCR	174

cDNA source data(309)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(328) Genomic(3) cDNA(312) Primer pair(11) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008836 (Evidence)
Ensembl Gene Model	ENSMUSG00000028645 (Evidence)
Entrez Gene	20525 (Evidence)
UniGene	21002
DFCI	TC1573138
DoTS	DT.97383818
NIA Mouse Gene Index	U004733
Consensus CDS Project	CCDS18569.1
International Mouse Knockout Project Status	Slc2a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008836	VEGA Gene Model | MGI Sequence Detail	28620	C57BL/6J
transcript	OTTMUST00000020092	VEGA | MGI Sequence Detail	2607	Not Applicable
polypeptide	OTTMUSP00000009212	VEGA | MGI Sequence Detail	492	Not Applicable

All sequences(48) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(6) : SNPs within 2kb(198 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR002439	Glucose transporter, type 1 (GLUT1)
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR003663	Sugar/inositol transporter
InterPro	IPR005829	Sugar transporter, conserved site
Protein Ontology	PR:000015058	solute carrier family 2, facilitated glucose transporter member 1

References

(Earliest) J:16692 Kaestner KH, et al., Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(13):4937]. Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4
(Latest) J:199438 Siegenthaler JA, et al., Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15;2(7):647-59
All references(186)

Other accession IDs

MGD-MRK-10155, MGD-MRK-10159