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Slc2a1
Gene Detail
Symbol

Name
ID
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
MGI:95755
Synonyms
Glut1, Glut-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
55.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr4:119108711-119137330 bp, + strand
From VEGA annotation of GRCm38

  28620 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: SLC2A1
Gene Tree: Slc2a1

Human
homologs
SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6513
neXtProt AC: NX_P11166

Human Synonyms: CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT-1, GLUT1DS, HTLVR, PED

Human Chr (Location): 1p34.2; chr1:42925375-42959176 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(65) Targeted(5) Transgenic(1)
Genomic Mutations involving Slc2a1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos are small, lack visibly detectable eyes, show a diminutive rostral embryonic pole and an overall developmental delay, and die at E10-E14. Heterozygotes show spontaneous seizures, impaired motor performance, hypoglycorrhachia, microencephaly, and reduced brain glucose uptake.
 
Phenotype Images(1)
Interactions
Slc2a1 interacts with 199 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (79 records)
Data Summary: Results (466)    Tissues (119)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 253
Northern blot 25
Western blot 17
RT-PCR 169
cDNA source data(309)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc2a1 ; ZFIN slc2a1a, slc2a1b    NEW 
Molecular
reagents
All nucleic(328) Genomic(3) cDNA(312) Primer pair(11) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008836 (Evidence)
Ensembl Gene Model ENSMUSG00000028645 (Evidence)
Entrez Gene 20525 (Evidence)
UniGene 21002
DFCI TC1573138
DoTS DT.97383818
NIA Mouse Gene Index U004733
Consensus CDS Project CCDS18569.1
International Mouse Phenotyping Consortium Status Slc2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008836 VEGA Gene Model | MGI Sequence Detail 28620 C57BL/6J ±  kb
transcript OTTMUST00000020092 VEGA | MGI Sequence Detail 2607 Not Applicable 
polypeptide OTTMUSP00000009212 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(6) : SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR002439 Glucose transporter, type 1 (GLUT1)
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR003663 Sugar/inositol transporter
InterPro IPR005829 Sugar transporter, conserved site
Protein Ontology PR:000015058 solute carrier family 2, facilitated glucose transporter member 1
References
(Earliest) J:16692 Kaestner KH, et al., Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(13):4937]. Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4
(Latest) J:218695 Soggia A, et al., von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A upregulation. Diabetologia. 2014 Nov;57(11):2348-56
All references(194)
Other
accession IDs
MGD-MRK-10155, MGD-MRK-10159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory