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Glra3 Gene Detail
Summary
  • Symbol
    Glra3
  • Name
    glycine receptor, alpha 3 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95749
    NCBI Gene: 110304
  • Gene Overview
    MyGene.info: GLRA3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:55940411-56125352 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    663 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95749
protein coding gene Chr8:55940411-56130070 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033617
protein coding gene Chr8:55623087-55811408 (+)
A/J MGP_AJ_G0033599
protein coding gene Chr8:53284905-53472202 (+)
AKR/J MGP_AKRJ_G0033524
protein coding gene Chr8:54870346-55051899 (+)
BALB/cJ MGP_BALBcJ_G0033596
protein coding gene Chr8:53612347-53795724 (+)
C3H/HeJ MGP_C3HHeJ_G0033305
protein coding gene Chr8:55551862-55737532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034112
protein coding gene Chr8:57729411-57937636 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031060
protein coding gene Chr8:48943994-49121068 (+)
CAST/EiJ MGP_CASTEiJ_G0032631
protein coding gene Chr8:54896017-55102221 (+)
CBA/J MGP_CBAJ_G0033284
protein coding gene Chr8:59774042-59992119 (+)
DBA/2J MGP_DBA2J_G0033437
protein coding gene Chr8:53120278-53300077 (+)
FVB/NJ MGP_FVBNJ_G0033378
protein coding gene Chr8:52487521-52676398 (+)
LP/J MGP_LPJ_G0033525
protein coding gene Chr8:55648666-55839015 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033422
protein coding gene Chr8:61253950-61542991 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034130
protein coding gene Chr8:55106002-55293272 (+)
PWK/PhJ MGP_PWKPhJ_G0032339
protein coding gene Chr8:52437311-52619584 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032175
protein coding gene Chr8:54020126-54208610 (+)
WSB/EiJ MGP_WSBEiJ_G0032747
protein coding gene Chr8:55313996-55506404 (+)



Homology
more
  • Human Ortholog
    GLRA3, glycine receptor alpha 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLRA3, glycine receptor alpha 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8001
    neXtProt AC: NX_O75311
    UniProt: O75311

  • Chr Location
    4q34.1; chr4:174642011-174829568 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 142
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLRA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110304 NCBI Gene Model | MGI Sequence Detail 184942 C57BL/6J ±  kb
    transcript NM_080438 RefSeq | MGI Sequence Detail 1474 C57BL/6  
    polypeptide Q91XP5 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR008127 Glycine receptor alpha
      IPR008130 Glycine receptor alpha3
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10132
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
    • Latest
      J:244005 McCracken LM, et al., Glycine receptor alpha3 and alpha2 subunits mediate tonic and exogenous agonist-induced currents in forebrain. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7179-E7186

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory