Glra3
Gene Detail

Symbol Name ID

Glra3 glycine receptor, alpha 3 subunit MGI:95749

Feature Type

protein coding gene

Genetic Map

Chromosome 8

29.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:55940460-56125429 bp, + strand From VEGA annotation of GRCm38   184970 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Glra3 ± 2 cM)

Gene Tree: Glra3

Human ortholog

GLRA3 glycine receptor, alpha 3 NCBI Gene ID 8001
Human Chr4:175563198-175750465 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	chloride transport, ion transport, ...
Component	cell junction, chloride channel complex, ...
Function	chloride channel activity, extracellular-glycine-gated chloride channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (85)    Tissues (48)    Images (15)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	7
In situ reporter (knock in)	40
RT-PCR	38

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(3) Primer pair(1) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000036483 (Evidence)
Ensembl Gene Model	ENSMUSG00000038257 (Evidence)
Entrez Gene	110304 (Evidence)
UniGene	307061
DFCI	TC1590941, TC1655152
DoTS	DT.101708472, DT.91446554
NIA Mouse Gene Index	U009347
Consensus CDS Project	CCDS40340.1
International Mouse Knockout Project Status	Glra3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036483	VEGA Gene Model | MGI Sequence Detail	184970	C57BL/6J
transcript	OTTMUST00000093512	VEGA | MGI Sequence Detail	1867	Not Applicable
polypeptide	OTTMUSP00000051884	VEGA | MGI Sequence Detail	480	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(561 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR008127	Glycine receptor alpha
InterPro	IPR008130	Glycine receptor alpha3
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000008044	glycine receptor subunit alpha-3

References

(Earliest) J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
(Latest) J:189039 Xiong W, et al., Cannabinoids suppress inflammatory and neuropathic pain by targeting alpha3 glycine receptors. J Exp Med. 2012 Jun 4;209(6):1121-34
All references(45)

Other accession IDs

MGD-MRK-10132