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Glra3 Gene Detail
Summary
  • Symbol
    Glra3
  • Name
    glycine receptor, alpha 3 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95749
    NCBI Gene: 110304
  • Gene Overview
    MyGene.info: GLRA3
Location & Maps
more
  • Sequence Map
    Chr8:55940460-56125429 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      184970 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GLRA3, glycine receptor alpha 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLRA3, glycine receptor alpha 3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 8001
    neXtProt AC: NX_O75311

  • Chr Location
    4q34.1; chr4:174624141-174829315 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 142
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GLRA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Glra3
  • Incidental Mutations
Homozygous null mice are fertile and display decreased inflammatory pain sensitization without any gross abnormalities in the brain or spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036483 VEGA Gene Model | MGI Sequence Detail 184970 C57BL/6J ±  kb
transcript OTTMUST00000093512 VEGA | MGI Sequence Detail 1867 Not Applicable  
polypeptide OTTMUSP00000051884 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    663 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008044 glycine receptor subunit alpha-3
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008127 Glycine receptor alpha
    IPR008130 Glycine receptor alpha3
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 6
    cDNA 3
    Primer pair 1
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10132
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
  • Latest
    J:210029 Notelaers K, et al., Analysis of alpha3 GlyR single particle tracking in the cell membrane. Biochim Biophys Acta. 2014 Mar;1843(3):544-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory