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Glra2 Gene Detail
Summary
  • Symbol
    Glra2
  • Name
    glycine receptor, alpha 2 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95748
    NCBI Gene: 237213
  • Gene Overview
    MyGene.info: GLRA2
Location & Maps
more
  • Sequence Map
    ChrX:165129017-165327393 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      198377 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.75 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
    Orthology source: HomoloGene
  • Synonyms
    GLR
  • Links
    NCBI Gene ID: 2742
    neXtProt AC: NX_P23416

  • Chr Location
    Xp22.2; chrX:14448779-14731812 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31070
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GLRA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Incidental Mutations
    APF
Mice homozygous for a null allele lack cortical neuron responses to glycine and taurine but are otherwise normal. Mice homozygous for another targeted allele exhibit impaired interneuron migration into the cortical wall.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019555 VEGA Gene Model | MGI Sequence Detail 198377 C57BL/6J ±  kb
transcript OTTMUST00000046696 VEGA | MGI Sequence Detail 3150 Not Applicable  
polypeptide OTTMUSP00000021108 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    815 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008043 glycine receptor subunit alpha-2
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008127 Glycine receptor alpha
    IPR008129 Glycine receptor alpha2
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 23
    Genomic 8
    cDNA 13
    Other 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10131
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
  • Latest
    J:230095 Avila A, et al., Glycine receptors control the generation of projection neurons in the developing cerebral cortex. Cell Death Differ. 2014 Nov;21(11):1696-708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory