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Glra2 Gene Detail
Summary
  • Symbol
    Glra2
  • Name
    glycine receptor, alpha 2 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95748
    NCBI Gene: 237213
  • Gene Overview
    MyGene.info: GLRA2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:165129017-165327393 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.75 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    815 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95748
protein coding gene ChrX:165129017-165327867 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036262
protein coding gene ChrX:163254391-163462378 (-)
A/J MGP_AJ_G0036231
protein coding gene ChrX:162385430-162598811 (-)
AKR/J MGP_AKRJ_G0036160
protein coding gene ChrX:167622657-167826382 (-)
BALB/cJ MGP_BALBcJ_G0036225
protein coding gene ChrX:160390942-160598009 (-)
C3H/HeJ MGP_C3HHeJ_G0035932
protein coding gene ChrX:163573384-163784036 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036748
protein coding gene ChrX:168015726-168225454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033568
protein coding gene ChrX:153395888-153598243 (-)
CAST/EiJ MGP_CASTEiJ_G0035219
protein coding gene ChrX:142524640-142724945 (-)
CBA/J MGP_CBAJ_G0035906
protein coding gene ChrX:172917298-173126218 (-)
DBA/2J MGP_DBA2J_G0036072
protein coding gene ChrX:161257979-161456622 (-)
FVB/NJ MGP_FVBNJ_G0036004
protein coding gene ChrX:160388475-160583157 (-)
LP/J MGP_LPJ_G0036157
protein coding gene ChrX:164367565-164577446 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036036
protein coding gene ChrX:181630342-181874102 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036787
protein coding gene ChrX:162730723-162939994 (-)
PWK/PhJ MGP_PWKPhJ_G0034918
protein coding gene ChrX:139296810-139500311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034738
protein coding gene ChrX:143038729-143248426 (-)
WSB/EiJ MGP_WSBEiJ_G0035355
protein coding gene ChrX:160669805-160873584 (-)



Homology
more
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GLRA2, glycine receptor alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLR
  • Links
    NCBI Gene ID: 2742
    neXtProt AC: NX_P23416
    UniProt: P23416

  • Chr Location
    Xp22.2; chrX:14448779-14731812 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31070
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLRA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele lack cortical neuron responses to glycine and taurine but are otherwise normal. Mice homozygous for another targeted allele exhibit impaired interneuron migration into the cortical wall.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018589 Ensembl Gene Model | MGI Sequence Detail 198377 C57BL/6J ±  kb
transcript ENSMUST00000058787 Ensembl | MGI Sequence Detail 3150 Not Applicable  
polypeptide ENSMUSP00000060827 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008043 glycine receptor subunit alpha-2
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008127 Glycine receptor alpha
    IPR008129 Glycine receptor alpha2
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Molecular
Reagents
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  • All nucleic 24
    Genomic 9
    cDNA 13
    Other 2

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-10131
References
more
  • Summaries
    All 53
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:11417 Derry JM, et al., Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome. Genomics. 1991 Jul;10(3):593-7
  • Latest
    J:244005 McCracken LM, et al., Glycine receptor alpha3 and alpha2 subunits mediate tonic and exogenous agonist-induced currents in forebrain. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7179-E7186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory