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Hagh Gene Detail
Summary
  • Symbol
    Hagh
  • Name
    hydroxyacyl glutathione hydrolase
  • Synonyms
    Glo2, Glo-2, Rsp29
  • Feature Type
    protein coding gene
  • IDs
    MGI:95745
    NCBI Gene: 14651
  • Gene Overview
    MyGene.info: HAGH
Location & Maps
more
  • Sequence Map
    Chr17:24840143-24864450 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24308 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
    Orthology source: HomoloGene
  • Synonyms
    GLO2, GLX2, GLXII, HAGH1
  • Links
    NCBI Gene ID: 3029
    neXtProt AC: NX_Q16775

  • Chr Location
    16p13.3; chr16:1809103-1827194 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3890
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HAGH
  • Protein SuperFamily
    Glx
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human HAGH associations

Human Disease Mouse Models
       Hydroxyacyl Glutathione Hydrolase Deficiency   OMIM: 614033
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026374 VEGA Gene Model | MGI Sequence Detail 24308 C57BL/6J ±  kb
transcript OTTMUST00000065224 VEGA | MGI Sequence Detail 1191 Not Applicable  
polypeptide OTTMUSP00000032475 VEGA | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    322 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008435 hydroxyacylglutathione hydrolase
  • EC
  • InterPro Domains
    IPR017782 Hydroxyacylglutathione hydrolase
    IPR032282 Hydroxyacylglutathione hydrolase, C-terminal domain
    IPR001279 Metallo-beta-lactamase
Molecular
Reagents
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  • All nucleic 119
    cDNA 118
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10123, MGD-MRK-10127, MGD-MRK-10610, MGI:3039638
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
  • Latest
    J:178902 Belanger M, et al., Role of the glyoxalase system in astrocyte-mediated neuroprotection. J Neurosci. 2011 Dec 14;31(50):18338-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory