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Hagh
Gene Detail
 Symbol
Name
ID
Hagh
hydroxyacyl glutathione hydrolase
MGI:95745
Synonyms Glo2, Glo-2, Rsp29
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:24840143-24864450 bp, + strand
From VEGA annotation of GRCm38

  24308 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Glx
Gene Tree: Hagh

Human
homologs
Human Homolog HAGH, hydroxyacylglutathione hydrolase
NCBI Gene ID 3029
neXtProt AC  NX_Q16775
Human Synonyms  GLO2, GLX2, GLXII, HAGH1
Human Chr (Location)  16p13.3; chr16:1809103-1827194 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HAGH
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hagh interacts with 62 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process carbohydrate metabolic process, glutathione biosynthetic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function hydrolase activity, hydroxyacylglutathione hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (19)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(118)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(119) cDNA(118) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026374 (Evidence)
Ensembl Gene ModelENSMUSG00000024158 (Evidence)
Entrez Gene14651 (Evidence)
UniGene43784
DFCITC1572939
NIA Mouse Gene IndexU017653
EC3.1.2.6
Consensus CDS ProjectCCDS28499.2, CCDS50021.1
International Mouse Knockout Project StatusHagh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026374 VEGA Gene Model | MGI Sequence Detail 24308 C57BL/6J ±  kb
transcript OTTMUST00000065224 VEGA | MGI Sequence Detail 1191 Not Applicable 
polypeptide OTTMUSP00000032475 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001279 Beta-lactamase-like
InterPro IPR017782 Hydroxyacylglutathione hydrolase
Protein Ontology PR:000008435 hydroxyacylglutathione hydrolase
References (Earliest) J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
(Latest) J:178902 Belanger M, et al., Role of the glyoxalase system in astrocyte-mediated neuroprotection. J Neurosci. 2011 Dec 14;31(50):18338-52
All references(36)
Other
accession IDs
MGD-MRK-10123, MGD-MRK-10127, MGD-MRK-10610, MGI:3039638

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory