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Hagh Gene Detail
Summary
  • Symbol
    Hagh
  • Name
    hydroxyacyl glutathione hydrolase
  • Synonyms
    Glo2, Glo-2, Rsp29
  • Feature Type
    protein coding gene
  • IDs
    MGI:95745
    NCBI Gene: 14651
  • Gene Overview
    MyGene.info: HAGH
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24840143-24864450 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95745
protein coding gene Chr17:24840079-24864450 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023325
protein coding gene Chr17:23876233-23889930 (+)
A/J MGP_AJ_G0023285
protein coding gene Chr17:23212905-23226649 (+)
AKR/J MGP_AKRJ_G0023252
protein coding gene Chr17:23301445-23315197 (+)
BALB/cJ MGP_BALBcJ_G0023290
protein coding gene Chr17:23413501-23427209 (+)
C3H/HeJ MGP_C3HHeJ_G0023050
protein coding gene Chr17:23664688-23678388 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023733
protein coding gene Chr17:24937895-24952796 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021207
protein coding gene Chr17:20663792-20688455 (+)
CAST/EiJ MGP_CASTEiJ_G0022552
protein coding gene Chr17:23520945-23534717 (+)
CBA/J MGP_CBAJ_G0023026
protein coding gene Chr17:25780372-25794070 (+)
DBA/2J MGP_DBA2J_G0023155
protein coding gene Chr17:22805225-22818971 (+)
FVB/NJ MGP_FVBNJ_G0023125
protein coding gene Chr17:22525743-22539771 (+)
LP/J MGP_LPJ_G0023232
protein coding gene Chr17:24180482-24195010 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023144
protein coding gene Chr17:25471415-25485447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023771
protein coding gene Chr17:23585928-23599674 (+)
PWK/PhJ MGP_PWKPhJ_G0022301
protein coding gene Chr17:21560614-21574776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022115
protein coding gene Chr17:21619085-21664040 (+)
WSB/EiJ MGP_WSBEiJ_G0022615
protein coding gene Chr17:23658637-23672296 (+)



Homology
more
  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLO2, GLX2, GLXII, HAGH1
  • Links
    NCBI Gene ID: 3029
    neXtProt AC: NX_Q16775
    UniProt: Q16775

  • Chr Location
    16p13.3; chr16:1809099-1827194 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3890
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HAGH
  • Protein SuperFamily
    Glx
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024158 Ensembl Gene Model | MGI Sequence Detail 24308 C57BL/6J ±  kb
transcript ENSMUST00000118788 Ensembl | MGI Sequence Detail 1191 Not Applicable  
polypeptide ENSMUSP00000113051 Ensembl | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 120
    cDNA 119
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10123, MGD-MRK-10127, MGD-MRK-10610, MGI:3039638
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
  • Latest
    J:178902 Belanger M, et al., Role of the glyoxalase system in astrocyte-mediated neuroprotection. J Neurosci. 2011 Dec 14;31(50):18338-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory