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Glul Gene Detail
Summary
  • Symbol
    Glul
  • Name
    glutamate-ammonia ligase (glutamine synthetase)
  • Synonyms
    Glns, GS
  • Feature Type
    protein coding gene
  • IDs
    MGI:95739
    NCBI Gene: 14645
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153899944-153909723 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.43 cM, cytoband G2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95739
protein coding gene Chr1:153899929-153909723 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016606
protein coding gene Chr1:158761851-158771606 (+)
A/J MGP_AJ_G0016587
protein coding gene Chr1:152359579-152369356 (+)
AKR/J MGP_AKRJ_G0016553
protein coding gene Chr1:157079646-157089418 (+)
BALB/cJ MGP_BALBcJ_G0016548
protein coding gene Chr1:152908368-152918610 (+)
C3H/HeJ MGP_C3HHeJ_G0016372
protein coding gene Chr1:157190164-157199991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017009
protein coding gene Chr1:164242454-164257514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014718
protein coding gene Chr1:144640076-144649966 (+)
CAST/EiJ MGP_CASTEiJ_G0015952
protein coding gene Chr1:156697639-156709264 (+)
CBA/J MGP_CBAJ_G0016347
protein coding gene Chr1:170034544-170044545 (+)
DBA/2J MGP_DBA2J_G0016453
protein coding gene Chr1:151376385-151390173 (+)
FVB/NJ MGP_FVBNJ_G0016451
protein coding gene Chr1:149834780-149842868 (+)
LP/J MGP_LPJ_G0016524
protein coding gene Chr1:159906709-159918540 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016476
protein coding gene Chr1:177652963-177662738 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017045
protein coding gene Chr1:156855737-156867111 (+)
PWK/PhJ MGP_PWKPhJ_G0015738
protein coding gene Chr1:150433258-150443628 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015525
protein coding gene Chr1:155649452-155660162 (+)
WSB/EiJ MGP_WSBEiJ_G0016014
protein coding gene Chr1:156938910-156949722 (+)



Homology
more
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLNS, GS, PIG43, PIG59
  • Links
    NCBI Gene ID: 2752
    neXtProt AC: NX_P15104
    UniProt: P15104

  • Chr Location
    1q25.3; chr1:182378093-182392206 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37567
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLUL
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Glul mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026473 Ensembl Gene Model | MGI Sequence Detail 9780 C57BL/6J ±  kb
    transcript ENSMUST00000086199 Ensembl | MGI Sequence Detail 2792 Not Applicable  
    polypeptide ENSMUSP00000083375 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 252
      Genomic 10
      cDNA 238
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10117
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 116
      Diseases 1
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
    • Latest
      J:274941 Adebayo Michael AO, et al., Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by beta-Catenin Mutations. Cell Metab. 2019 May 7;29(5):1135-1150.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory