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Glul Gene Detail
Summary
  • Symbol
    Glul
  • Name
    glutamate-ammonia ligase (glutamine synthetase)
  • Synonyms
    Glns, GS
  • Feature Type
    protein coding gene
  • IDs
    MGI:95739
    NCBI Gene: 14645
Location & Maps
more
  • Sequence Map
    Chr1:153899944-153909723 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9780 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.43 cM, cytoband G2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLNS, GS, PIG43, PIG59
  • Links
    NCBI Gene ID: 2752
    neXtProt AC: NX_P15104

  • Chr Location
    1q31; chr1:182378093-182392206 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 37567
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GLUL
  • Gene Tree
    Glul
Human Diseases
more
  • Diseases
    1 with human GLUL associations

Human Disease Mouse Models
       Glutamine Deficiency, Congenital   OMIM: 610015
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Gene trapped
    12
  • Targeted
    6
  • Genomic Mutations
    2 involving Glul
  • Incidental Mutations
    APF , CvDC
Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    172
  • Tissues
    150
  • cDNA Data
    234
  • Literature Summary
    91
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016462 VEGA Gene Model | MGI Sequence Detail 9780 C57BL/6J ±  kb
transcript OTTMUST00000039662 VEGA | MGI Sequence Detail 2792 Not Applicable  
polypeptide OTTMUSP00000017702 VEGA | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    101 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008058 glutamine synthetase
  • EC
    4.1.1.15, 6.3.1.2
  • InterPro Domains
    IPR008147 Glutamine synthetase, beta-Grasp domain
    IPR008146 Glutamine synthetase, catalytic domain
    IPR027303 Glutamine synthetase, glycine-rich site
    IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    IPR027302 Glutamine synthetase, N-terminal conserved site
Molecular
Reagents
less
  • All nucleic 249
    Genomic 10
    cDNA 236
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-10117
References
more
  • Summaries
    All 147
    Developmental Gene Expression 91
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
  • Latest
    J:231601 de Melo J, et al., Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory