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Glul
Gene Detail
Symbol

Name
ID
Glul
glutamate-ammonia ligase (glutamine synthetase)
MGI:95739
Synonyms
Glns, GS
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.43 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:153899944-153909723 bp, + strand
From VEGA annotation of GRCm38

  9780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Glul

Human
homologs
Human Homolog GLUL, glutamate-ammonia ligase
NCBI Gene ID 2752
neXtProt AC  NX_P15104
Human Synonyms  GLNS, GS, PIG43, PIG59
Human Chr (Location)  1q31; chr1:182381704-182392206 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLUL
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from APF )
 
Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.
 
Interactions
Glul interacts with 199 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process ammonia assimilation cycle, cell proliferation, ...
Component axon terminus, cell body, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (162)    Tissues (147)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 137
In situ reporter (knock in) 7
Northern blot 2
RT-PCR 7
cDNA source data(234)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(249) Genomic(10) cDNA(236) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016462 (Evidence)
Ensembl Gene ModelENSMUSG00000026473 (Evidence)
Entrez Gene14645 (Evidence)
UniGene210745
DFCITC1573428, TC1687691
DoTSDT.101707316, DT.536603, DT.94305655, DT.94344822
EC4.1.1.15, 6.3.1.2
Consensus CDS ProjectCCDS15381.1
International Mouse Knockout Project StatusGlul
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016462 VEGA Gene Model | MGI Sequence Detail 9780 C57BL/6J ±  kb
transcript OTTMUST00000039662 VEGA | MGI Sequence Detail 2792 Not Applicable 
polypeptide OTTMUSP00000017702 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008147 Glutamine synthetase, beta-Grasp
InterPro IPR008146 Glutamine synthetase, catalytic domain
InterPro IPR027303 Glutamine synthetase, glycine-rich site
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
InterPro IPR027302 Glutamine synthetase, N-terminal conserved site
Protein Ontology PR:000008058 glutamine synthetase
References
(Earliest) J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(138)
Other
accession IDs
MGD-MRK-10117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory