Glul MGI Mouse Gene Detail - MGI:95739 - glutamate-ammonia ligase (glutamine synthetase)

Glul Gene Detail

Symbol

Glul
Name

glutamate-ammonia ligase (glutamine synthetase)
Synonyms

Glns, GS

Feature Type

protein coding gene
IDs

MGI:95739
NCBI Gene: 14645

Sequence Map

Chr1:153899944-153909723 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

9780 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.43 cM, cytoband G2
Mapping Data

1 experiment

Human Ortholog

GLUL, glutamate-ammonia ligase

Vertebrate Orthologs

10

Human Ortholog

GLUL, glutamate-ammonia ligase
Orthology source: HomoloGene, HGNC
Synonyms

GLNS, GS, PIG43, PIG59
Links

HGNC:4341

NCBI Gene ID: 2752

neXtProt AC: NX_P15104

UniProt: P15104
Chr Location

1q25.3; chr1:182378093-182392206 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 37567
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GLUL
Gene Tree

Glul

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Phenotype Summary

18 phenotypes from 4 alleles in 6 genetic backgrounds
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Gene trapped

12
Targeted

6
Genomic Mutations

2 involving Glul
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.

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All GO Annotations

45
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

175
Tissues

153
cDNA Data

234
Literature Summary

98

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GLUL

ZFIN glula, glulb

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Glul interacts with 199 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS15381.1
UniGene

210745

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016462	VEGA Gene Model \| MGI Sequence Detail	9780	C57BL/6J	± kb
transcript	OTTMUST00000039662	VEGA \| MGI Sequence Detail	2792	Not Applicable
polypeptide	OTTMUSP00000017702	VEGA \| MGI Sequence Detail	373	Not Applicable

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SNPs within 2kb

101 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000008058 glutamine synthetase

(term hierarchy)
EC

4.1.1.15, 6.3.1.2
InterPro Domains

IPR008147 Glutamine synthetase, beta-Grasp domain

IPR008146 Glutamine synthetase, catalytic domain

IPR027303 Glutamine synthetase, glycine-rich site

IPR014746 Glutamine synthetase/guanido kinase, catalytic domain

IPR027302 Glutamine synthetase, N-terminal conserved site

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All nucleic 249

Genomic 10

cDNA 236

Primer pair 2

Other 1

Microarray probesets 6

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MGD-MRK-10117

Summaries

All 157

Developmental Gene Expression 98

Gene Ontology 13

Phenotypes 13
Earliest

J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
Latest

J:241509 Chang KC, et al., Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017 May 10;37(19):4967-4981

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/19/2017 MGI 6.10