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Glul Gene Detail
Summary
  • Symbol
    Glul
  • Name
    glutamate-ammonia ligase (glutamine synthetase)
  • Synonyms
    Glns, GS
  • Feature Type
    protein coding gene
  • IDs
    MGI:95739
    NCBI Gene: 14645
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:153899944-153909723 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9780 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.43 cM, cytoband G2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLUL, glutamate-ammonia ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLNS, GS, PIG43, PIG59
  • Links
    NCBI Gene ID: 2752
    neXtProt AC: NX_P15104
    UniProt: P15104

  • Chr Location
    1q25.3; chr1:182378093-182392206 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 37567
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLUL
  • Gene Tree
    Glul
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    175
  • Tissues
    153
  • cDNA Data
    234
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016462 VEGA Gene Model | MGI Sequence Detail 9780 C57BL/6J ±  kb
    transcript OTTMUST00000039662 VEGA | MGI Sequence Detail 2792 Not Applicable  
    polypeptide OTTMUSP00000017702 VEGA | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      101 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 249
      Genomic 10
      cDNA 236
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10117
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 109
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
    • Latest
      J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory