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Glul
Gene Detail
 Symbol
Name
ID
Glul
glutamate-ammonia ligase (glutamine synthetase)
MGI:95739
Synonyms Glns, GS
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.43 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:153899944-153909723 bp, + strand
From VEGA annotation of GRCm38

  9780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37567  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glul

Human
homologs
Human Homolog GLUL, glutamate-ammonia ligase
NCBI Gene ID 2752
neXtProt AC  NX_P15104
Human Synonyms  GLNS, GS, PIG43, PIG59
Human Chr (Location)  1q31; chr1:182381704-182392206 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLUL
Alleles
and
phenotypes
All alleles(17) : Targeted(5) Gene trapped(12)
 
Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell proliferation, cellular response to starvation, ...
Component cell body, cytoplasm, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (151)    Tissues (139)    Images (23)
Theiler Stages: 20, 22, 24, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 137
Northern blot 2
RT-PCR 7
cDNA source data(234)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(249) Genomic(10) cDNA(236) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016462 (Evidence)
Ensembl Gene ModelENSMUSG00000026473 (Evidence)
Entrez Gene14645 (Evidence)
UniGene210745
DFCITC1573428, TC1687691
DoTSDT.101707316, DT.536603, DT.94305655, DT.94344822
EC4.1.1.15, 6.3.1.2
Consensus CDS ProjectCCDS15381.1
International Mouse Knockout Project StatusGlul
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016462 VEGA Gene Model | MGI Sequence Detail 9780 C57BL/6J ±  kb
transcript OTTMUST00000039662 VEGA | MGI Sequence Detail 2792 Not Applicable 
polypeptide OTTMUSP00000017702 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008147 Glutamine synthetase, beta-Grasp
InterPro IPR008146 Glutamine synthetase, catalytic domain
InterPro IPR027303 Glutamine synthetase, glycine-rich site
InterPro IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
InterPro IPR027302 Glutamine synthetase, N-terminal conserved site
Protein Ontology PR:000008058 glutamine synthetase
References (Earliest) J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
(Latest) J:203004 Karunakaran DK, et al., The expression analysis of Sfrs10 and Celf4 during mouse retinal development. Gene Expr Patterns. 2013 Dec;13(8):425-36
All references(131)
Other
accession IDs
MGD-MRK-10117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory