Glul
Gene Detail

Symbol Name ID

Glul glutamate-ammonia ligase (glutamine synthetase) MGI:95739

Synonyms

Glns, GS

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.43 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:153899944-153909723 bp, + strand From VEGA annotation of GRCm38   9780 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Glul

Human homologs

Human Homolog		GLUL, glutamate-ammonia ligase
NCBI Gene ID		2752
neXtProt AC		NX_P15104
Human Synonyms		GLNS, GS, PIG43, PIG59
Human Chr (Location)		1q31; chr1:182381704-182392206 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human GLUL

Mutations, alleles, and phenotypes

All mutations/alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from APF )
 

Embryos homozygous for a reporter/null allele are not viable after E3.5; however, mutant E2.5 embryonic cells can survive in vitro if provided with glutamine.

 

Interactions

Glul interacts with 199 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	ammonia assimilation cycle, cell proliferation, ...
Component	axon terminus, cell body, ...
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (79 records)

Data Summary: Results (162)    Tissues (146)    Images (33)
Theiler Stages: 4, 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	137
In situ reporter (knock in)	7
Northern blot	2
RT-PCR	7

cDNA source data(234)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(249) Genomic(10) cDNA(236) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016462 (Evidence)
Ensembl Gene Model	ENSMUSG00000026473 (Evidence)
Entrez Gene	14645 (Evidence)
UniGene	210745
DFCI	TC1573428, TC1687691
DoTS	DT.101707316, DT.536603, DT.94305655, DT.94344822
EC	4.1.1.15, 6.3.1.2
Consensus CDS Project	CCDS15381.1
International Mouse Knockout Project Status	Glul

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016462	VEGA Gene Model | MGI Sequence Detail	9780	C57BL/6J
transcript	OTTMUST00000039662	VEGA | MGI Sequence Detail	2792	Not Applicable
polypeptide	OTTMUSP00000017702	VEGA | MGI Sequence Detail	373	Not Applicable

All sequences(48) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(118 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008147	Glutamine synthetase, beta-Grasp
InterPro	IPR008146	Glutamine synthetase, catalytic domain
InterPro	IPR027303	Glutamine synthetase, glycine-rich site
InterPro	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain
InterPro	IPR027302	Glutamine synthetase, N-terminal conserved site
Protein Ontology	PR:000008058	glutamine synthetase

References

(Earliest) J:8188 Burns DM, et al., Selection of a rat glutamine synthetase cDNA clone. Biochem Biophys Res Commun. 1986 Jan 14;134(1):146-51
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(136)

Other accession IDs

MGD-MRK-10117