Galk1
Gene Detail

Symbol Name ID

Galk1 galactokinase 1 MGI:95730

Synonyms

GALK1, GK, Glk, Glk1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr11:116008457-116012719 bp, - strand From VEGA annotation of GRCm38   4263 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: galactokinase
Gene Tree: Galk1

Human homologs

Human Homolog		GALK1, galactokinase 1
NCBI Gene ID		2584
neXtProt AC		NX_P51570
Human Synonyms		GALK, GK1
Human Chr (Location)		17q24; chr17:73754018-73761280 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GALK1

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(3)
 

Mice homozygous for a knock-out allele are unable to metabolize galactose, display tissue accumulation of galactose and galactitol, but do not form cataracts even when fed a high galactose diet.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component	cytoplasm
Function	ATP binding, galactokinase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (101)    Images (15)
Theiler Stages: 17, 22, 23

Assay Type	Results
RNA in situ	106

cDNA source data(107)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(110) cDNA(107) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003691 (Evidence)
Ensembl Gene Model	ENSMUSG00000020766 (Evidence)
Entrez Gene	14635 (Evidence)
UniGene	2820
DFCI	TC1574958, TC1767576
DoTS	DT.491826
NIA Mouse Gene Index	U033637
EC	2.7.1.6
Consensus CDS Project	CCDS25654.1
International Mouse Knockout Project Status	Galk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003691	VEGA Gene Model | MGI Sequence Detail	4263	C57BL/6J
transcript	OTTMUST00000008005	VEGA | MGI Sequence Detail	1406	Not Applicable
polypeptide	OTTMUSP00000003891	VEGA | MGI Sequence Detail	392	Not Applicable

All sequences(31) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000705	Galactokinase
InterPro	IPR019741	Galactokinase, conserved site
InterPro	IPR019539	Galactokinase galactose-binding domain
InterPro	IPR006203	GHMP kinase, ATP-binding, conserved site
InterPro	IPR013750	GHMP kinase, C-terminal domain
InterPro	IPR006204	GHMP kinase N-terminal domain
InterPro	IPR006206	Mevalonate/galactokinase
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
InterPro	IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology	PR:000007813	galactokinase

References

(Earliest) J:5718 Mishkin JD, et al., Glk: a locus controlling galactokinase activity in the mouse. Biochem Genet. 1976 Aug;14(7-8):635-40
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(73)

Other accession IDs

MGD-MRK-10101, MGD-MRK-10108, MGI:2144004, MGI:95724