About   Help   FAQ
Galk1
Gene Detail
 Symbol
Name
ID
Galk1
galactokinase 1
MGI:95730
Synonyms GALK1, GK, Glk, Glk1
Feature Type protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr11:116008457-116012719 bp, - strand
From VEGA annotation of GRCm38

  4263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:125  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: galactokinase
Gene Tree: Galk1

Human
homologs
Human Homolog GALK1, galactokinase 1
NCBI Gene ID 2584
neXtProt AC  NX_P51570
Human Synonyms  GALK, GK1, HEL-S-19
Human Chr (Location)  17q24; chr17:75757937-75765199 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GALK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele are unable to metabolize galactose, display tissue accumulation of galactose and galactitol, but do not form cataracts even when fed a high galactose diet.
 
Interactions
Galk1 interacts with 22 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process carbohydrate metabolic process, carbohydrate phosphorylation, ...
Component cytoplasm, extracellular vesicular exosome
Function ATP binding, galactokinase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (101)    Images (15)
Theiler Stages: 17, 22, 23
Assay TypeResults
RNA in situ 106
cDNA source data(107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(107) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003691 (Evidence)
Ensembl Gene ModelENSMUSG00000020766 (Evidence)
Entrez Gene14635 (Evidence)
UniGene2820
DFCITC1574958, TC1767576
DoTSDT.491826
NIA Mouse Gene IndexU033637
EC2.7.1.6
Consensus CDS ProjectCCDS25654.1
International Mouse Knockout Project StatusGalk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003691 VEGA Gene Model | MGI Sequence Detail 4263 C57BL/6J ±  kb
transcript OTTMUST00000008005 VEGA | MGI Sequence Detail 1406 Not Applicable 
polypeptide OTTMUSP00000003891 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000705 Galactokinase
InterPro IPR019741 Galactokinase, conserved site
InterPro IPR019539 Galactokinase galactose-binding domain
InterPro IPR006203 GHMP kinase, ATP-binding, conserved site
InterPro IPR013750 GHMP kinase, C-terminal domain
InterPro IPR006204 GHMP kinase N-terminal domain
InterPro IPR006206 Mevalonate/galactokinase
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology PR:000007813 galactokinase
References (Earliest) J:5718 Mishkin JD, et al., Glk: a locus controlling galactokinase activity in the mouse. Biochem Genet. 1976 Aug;14(7-8):635-40
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(73)
Other
accession IDs
MGD-MRK-10101, MGD-MRK-10108, MGI:2144004, MGI:95724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory