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Gli2 Gene Detail
Summary
  • Symbol
    Gli2
  • Name
    GLI-Kruppel family member GLI2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95728
    NCBI Gene: 14633
  • Gene Overview
    MyGene.info: GLI2
Location & Maps
more
  • Sequence Map
    Chr1:118834132-119053619 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      219488 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.17 cM, cytoband E2-E4
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    GLI2, GLI family zinc finger 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLI2, GLI family zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CJS, HPE9, PHS2, THP1, THP2
  • Links
    NCBI Gene ID: 2736
    neXtProt AC: NX_P10070

  • Chr Location
    2q14; chr2:120797291-120992653 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12725
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GLI2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human GLI2 associations

Human Disease Mouse Models
       Culler-Jones Syndrome; CJS   OMIM: 615849
Holoprosencephaly 9; HPE9   OMIM: 610829
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 11 alleles in 17 genetic backgrounds
    92 phenotypes from multigenic genotypes
    1 images
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    191
  • Chemically induced (other)
    2
  • Gene trapped
    168
  • Radiation induced
    1
  • Targeted
    20
  • Genomic Mutations
    3 involving Gli2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034815 VEGA Gene Model | MGI Sequence Detail 219488 C57BL/6J ±  kb
transcript OTTMUST00000088493 VEGA | MGI Sequence Detail 6637 Not Applicable  
polypeptide OTTMUSP00000048224 VEGA | MGI Sequence Detail 1544 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1449 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000008027 zinc finger protein GLI2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 72
    Genomic 3
    cDNA 53
    Primer pair 8
    Other 8

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10106, MGI:2138602
References
more
  • Summaries
    All 308
    Developmental Gene Expression 182
    Gene Ontology 54
    Phenotypes 129
  • Earliest
    J:4086 Hui CC, et al., A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet. 1993 Mar;3(3):241-6
  • Latest
    J:234178 Perdigoto CN, et al., Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016 Jul;12(7):e1006151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory