Gli2
Gene Detail

Symbol Name ID

Gli2 GLI-Kruppel family member GLI2 MGI:95728

Feature Type

protein coding gene

Genetic Map

Chromosome 1

52.17 cM, cytoband E2-E4
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr1:118834132-119053619 bp, - strand From VEGA annotation of GRCm38   219488 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gli2

Human homologs

Human Homolog		GLI2, GLI family zinc finger 2
NCBI Gene ID		2736
neXtProt AC		NX_P10070
Human Synonyms		HPE9, THP1, THP2
Human Chr (Location)		2q14; chr2:121554867-121750229 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GLI2

Alleles and phenotypes

All alleles(183) : Targeted(15) Gene trapped(168)
 

Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5.

 

Gene Ontology (GO) classifications

All GO classifications: (108 annotations)

Process	anatomical structure development, anatomical structure formation involved in morphogenesis, ...
Component	cilium, cytoplasm, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (146 records)
Data Summary: Results (505)    Tissues (267)    Images (134)
Theiler Stages: 2, 3, 7, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	419
In situ reporter (knock in)	13
Northern blot	12
RT-PCR	57

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) Genomic(3) cDNA(52) Primer pair(7) Other(6)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000034815 (Evidence)
Ensembl Gene Model	ENSMUSG00000048402 (Evidence)
Entrez Gene	14633 (Evidence)
UniGene	273292
DFCI	TC1605280
DoTS	DT.483046
NIA Mouse Gene Index	U021691
Consensus CDS Project	CCDS35692.1
International Mouse Knockout Project Status	Gli2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034815	VEGA Gene Model | MGI Sequence Detail	219488	C57BL/6J
transcript	OTTMUST00000088493	VEGA | MGI Sequence Detail	6637	Not Applicable
polypeptide	OTTMUSP00000048224	VEGA | MGI Sequence Detail	1544	Not Applicable

All sequences(74) RefSeq(2) UniProt(12)

Polymorphisms

PCR(1) : SNPs(929 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000008027	zinc finger protein GLI2

References

(Earliest) J:4086 Hui CC, et al., A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet. 1993 Mar;3(3):241-6
(Latest) J:194893 Yu K, et al., Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
All references(255)

Other accession IDs

MGD-MRK-10106, MGI:2138602