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Gli2
Gene Detail
Symbol

Name
ID
Gli2
GLI-Kruppel family member GLI2
MGI:95728
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.17 cM, cytoband E2-E4
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr1:118834132-119053619 bp, - strand
From VEGA annotation of GRCm38

  219488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gli2

Human
homologs
Human Homolog GLI2, GLI family zinc finger 2
NCBI Gene ID 2736
neXtProt AC  NX_P10070
Human Synonyms  HPE9, PHS2, THP1, THP2
Human Chr (Location)  2q14; chr2:120797291-120992653 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GLI2
Mutations,
alleles, and
phenotypes
All mutations/alleles(183) : Gene trapped(168) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5.
 
Interactions
Gli2 interacts with 219 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (116 annotations)
Process anatomical structure development, anatomical structure formation involved in morphogenesis, ...
Component ciliary tip, cilium, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (162 records)
Data Summary: Results (537)    Tissues (302)    Images (149)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 435
In situ reporter (knock in) 13
Northern blot 20
RT-PCR 65
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) Genomic(3) cDNA(53) Primer pair(8) Other(7)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034815 (Evidence)
Ensembl Gene ModelENSMUSG00000048402 (Evidence)
Entrez Gene14633 (Evidence)
UniGene273292
DFCITC1605280
DoTSDT.483046
NIA Mouse Gene IndexU021691
Consensus CDS ProjectCCDS35692.1
International Mouse Knockout Project StatusGli2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034815 VEGA Gene Model | MGI Sequence Detail 219488 C57BL/6J ±  kb
transcript OTTMUST00000088493 VEGA | MGI Sequence Detail 6637 Not Applicable 
polypeptide OTTMUSP00000048224 VEGA | MGI Sequence Detail 1544 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(6) UniProt(21)
Polymorphisms
PCR(1) : SNPs within 2kb(1449 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008027 zinc finger protein GLI2
References
(Earliest) J:4086 Hui CC, et al., A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet. 1993 Mar;3(3):241-6
(Latest) J:214395 Hsu YC, et al., Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell. 2014 May 8;157(4):935-49
All references(286)
Other
accession IDs
MGD-MRK-10106, MGI:2138602

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory