About   Help   FAQ
Gli2 Gene Detail
Summary
  • Symbol
    Gli2
  • Name
    GLI-Kruppel family member GLI2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95728
    NCBI Gene: 14633
  • Gene Overview
    MyGene.info: GLI2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:118834132-119053619 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.17 cM, cytoband E2-E4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1449 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95728
protein coding gene Chr1:118834061-119053619 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016393
protein coding gene Chr1:121551105-121774272 (-)
A/J MGP_AJ_G0016376
protein coding gene Chr1:117203111-117424081 (-)
AKR/J MGP_AKRJ_G0016341
protein coding gene Chr1:120669763-120888740 (-)
BALB/cJ MGP_BALBcJ_G0016336
protein coding gene Chr1:117462661-117684028 (-)
C3H/HeJ MGP_C3HHeJ_G0016162
protein coding gene Chr1:120833168-121055465 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016797
protein coding gene Chr1:126210418-126437378 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014510
protein coding gene Chr1:110877319-111100852 (-)
CAST/EiJ MGP_CASTEiJ_G0015743
protein coding gene Chr1:119576849-119810417 (-)
CBA/J MGP_CBAJ_G0016135
protein coding gene Chr1:130563311-130796514 (-)
DBA/2J MGP_DBA2J_G0016241
protein coding gene Chr1:116216380-116436467 (-)
FVB/NJ MGP_FVBNJ_G0016240
protein coding gene Chr1:114955234-115178740 (-)
LP/J MGP_LPJ_G0016312
protein coding gene Chr1:122897532-123126590 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016265
protein coding gene Chr1:136325047-136548043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016833
protein coding gene Chr1:120361844-120589589 (-)
PWK/PhJ MGP_PWKPhJ_G0015529
protein coding gene Chr1:115192588-115418176 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015317
protein coding gene Chr1:119242480-119472185 (-)
WSB/EiJ MGP_WSBEiJ_G0015805
protein coding gene Chr1:120245989-120471374 (-)



Homology
more
  • Human Ortholog
    GLI2, GLI family zinc finger 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLI2, GLI family zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CJS, HPE9, PHS2, THP1, THP2
  • Links
    NCBI Gene ID: 2736
    neXtProt AC: NX_P10070
    UniProt: P10070

  • Chr Location
    2q14.2; chr2:120797291-120992653 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12725
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLI2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human GLI2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    107 phenotypes from 11 alleles in 17 genetic backgrounds
    98 phenotypes from multigenic genotypes
    1 images
    156 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048402 Ensembl Gene Model | MGI Sequence Detail 219488 C57BL/6J ±  kb
    transcript ENSMUST00000062483 Ensembl | MGI Sequence Detail 6637 Not Applicable  
    polypeptide ENSMUSP00000054837 Ensembl | MGI Sequence Detail 1544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 3
      cDNA 54
      Primer pair 9
      Other 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10106, MGI:2138602
    References
    more
    • Summaries
      All 380
      Developmental Gene Expression 218
      Diseases 1
      Gene Ontology 57
      Phenotypes 156
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:273907 Nandadasa S, et al., Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 Feb 27;10(1):953

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory