Gjb4
Gene Detail

Symbol Name ID

Gjb4 gap junction protein, beta 4 MGI:95722

Synonyms

connexin 30.3, Cx30.3, Gjb-4

Feature Type

protein coding gene

Genetic Map

Chromosome 4

61.51 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:127351086-127354081 bp, - strand From VEGA annotation of GRCm38   2996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7339  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Gjb4

Human homologs

Human Homolog		GJB4, gap junction protein, beta 4, 30.3kDa
NCBI Gene ID		127534
neXtProt AC		NX_Q9NTQ9
Human Synonyms		CX30.3, EKV
Human Chr (Location)		1p34.3; chr1:35225342-35229325 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GJB4

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Mice homozygous for a reporter allele display reduced behavioral responses to a vanilla scent, suggesting impaired olfaction.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell communication, olfactory behavior, ...
Component	cell junction, connexon complex, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 25

Assay Type	Results
RT-PCR	6

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(2) cDNA(5) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009380 (Evidence)
Ensembl Gene Model	ENSMUSG00000046623 (Evidence)
Entrez Gene	14621 (Evidence)
UniGene	56906
DFCI	TC1589767
DoTS	DT.101211246, DT.40173472
NIA Mouse Gene Index	U052489
Consensus CDS Project	CCDS18669.1
International Mouse Knockout Project Status	Gjb4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009380	VEGA Gene Model | MGI Sequence Detail	2996	C57BL/6J
transcript	OTTMUST00000021358	VEGA | MGI Sequence Detail	1446	Not Applicable
polypeptide	OTTMUSP00000009767	VEGA | MGI Sequence Detail	266	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000500	Connexin
InterPro	IPR017990	Connexin, conserved site
InterPro	IPR013092	Connexin, N-terminal
InterPro	IPR002271	Gap junction beta-5 protein (Cx30.3)
InterPro	IPR019570	Gap junction protein, cysteine-rich domain
Protein Ontology	PR:000008000	gap junction beta-4 protein

References

(Earliest) J:858 Willecke K, et al., The diversity of connexin genes encoding gap junctional proteins. Eur J Cell Biol. 1991 Oct;56(1):1-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)

Other accession IDs

MGD-MRK-10094, MGD-MRK-10099