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Gjb4
Gene Detail
 Symbol
Name
ID
Gjb4
gap junction protein, beta 4
MGI:95722
Synonyms connexin 30.3, Cx30.3, Gjb-4
Feature Type protein coding gene
Genetic Map
Chromosome 4
61.51 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:127351086-127354081 bp, - strand
From VEGA annotation of GRCm38

  2996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7339  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gjb4

Human
homologs
Human Homolog GJB4, gap junction protein, beta 4, 30.3kDa
NCBI Gene ID 127534
neXtProt AC  NX_Q9NTQ9
Human Synonyms  CX30.3, EKV
Human Chr (Location)  1p34.3; chr1:34759741-34763724 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GJB4
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele display reduced behavioral responses to a vanilla scent, suggesting impaired olfaction.
 
Interactions
Gjb4 interacts with 47 markers (Mir30b, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell communication, olfactory behavior, ...
Component cell junction, connexon complex, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 25
Assay TypeResults
RT-PCR 6
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(5) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009380 (Evidence)
Ensembl Gene ModelENSMUSG00000046623 (Evidence)
Entrez Gene14621 (Evidence)
UniGene56906
DFCITC1589767
DoTSDT.101211246, DT.40173472
NIA Mouse Gene IndexU052489
Consensus CDS ProjectCCDS18669.1
International Mouse Knockout Project StatusGjb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009380 VEGA Gene Model | MGI Sequence Detail 2996 C57BL/6J ±  kb
transcript OTTMUST00000021358 VEGA | MGI Sequence Detail 1446 Not Applicable 
polypeptide OTTMUSP00000009767 VEGA | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000500 Connexin
InterPro IPR017990 Connexin, conserved site
InterPro IPR013092 Connexin, N-terminal
InterPro IPR002271 Gap junction beta-5 protein (Cx30.3)
InterPro IPR019570 Gap junction protein, cysteine-rich domain
Protein Ontology PR:000008000 gap junction beta-4 protein
References (Earliest) J:858 Willecke K, et al., The diversity of connexin genes encoding gap junctional proteins. Eur J Cell Biol. 1991 Oct;56(1):1-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)
Other
accession IDs
MGD-MRK-10094, MGD-MRK-10099

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory