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Gjc1
Gene Detail
Symbol

Name
ID
Gjc1
gap junction protein, gamma 1
MGI:95718
Synonyms
C130009G16Rik, connexin 45, Cx45, Gja7, Gja-7
Feature Type
protein coding gene
Genetic Map
Chromosome 11
66.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:102799579-102819700 bp, - strand
From VEGA annotation of GRCm38

  20122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GJC1
Gene Tree: Gjc1

Human
homologs
GJC1, gap junction protein, gamma 1, 45kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10052
neXtProt AC: NX_P36383

Human Synonyms: CX45, GJA7

Human Chr (Location): 17q21.31; chr17:44793954-44830811 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(73) : Gene trapped(62) Targeted(11)
Genomic Mutations involving Gjc1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit impaired vascular and cardiac development resulting in retarded growth and lethality between embryonic day 9.5 -10.5.
 
Interactions
Gjc1 interacts with 129 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cardiac muscle tissue development, cell-cell signaling, ...
Component cell junction, connexon complex, ...
Function gap junction channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (222)    Tissues (78)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 125
In situ reporter (knock in) 34
Northern blot 15
RT-PCR 27
RNase protection 4
cDNA source data(33)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gjc1 ; ZFIN cx43.4    NEW 
Molecular
reagents
All nucleic(39) cDNA(33) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002993 (Evidence)
Ensembl Gene Model ENSMUSG00000034520 (Evidence)
Entrez Gene 14615 (Evidence)
UniGene 390369
DFCI TC1583220, TC1592793, TC1602913, TC1642056, TC1717481
DoTS DT.101350848, DT.101372067, DT.101372070, DT.101736014, DT.101736015, DT.55144672, DT.91300737
NIA Mouse Gene Index U033488
Consensus CDS Project CCDS25504.1
International Mouse Phenotyping Consortium Status Gjc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002993 VEGA Gene Model | MGI Sequence Detail 20122 C57BL/6J ±  kb
transcript OTTMUST00000006144 VEGA | MGI Sequence Detail 1890 Not Applicable 
polypeptide OTTMUSP00000002896 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000500 Connexin
InterPro IPR017990 Connexin, conserved site
InterPro IPR013092 Connexin, N-terminal
InterPro IPR002265 Gap junction alpha-6 protein (Cx45)
InterPro IPR019570 Gap junction protein, cysteine-rich domain
Protein Ontology PR:000008004 gap junction gamma-1 protein
References
(Earliest) J:769 Hennemann H, et al., Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs. Eur J Cell Biol. 1992 Feb;57(1):51-8
(Latest) J:215580 Akopian A, et al., Gap junction-mediated death of retinal neurons is connexin and insult specific: a potential target for neuroprotection. J Neurosci. 2014 Aug 6;34(32):10582-91
All references(105)
Other
accession IDs
MGD-MRK-10084, MGD-MRK-10090, MGI:2444591

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory